Mouse macrophages express specialized genes particular to the organs they inhabit, but whether the same applies in humans is unclear. In human peritoneal fluid, we identified many macrophage phenotypes, including two specialized macrophage types that corresponded to distinct mouse peritoneal macrophages. However, their abundances were markedly different between species.
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This is a summary of: Han, J. et al. Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species. Nat. Immunol. https://doi.org/10.1038/s41590-023-01688-7 (2024).
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Human and mouse peritoneal macrophages and dendritic cells compared. Nat Immunol 25, 17–18 (2024). https://doi.org/10.1038/s41590-023-01709-5
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DOI: https://doi.org/10.1038/s41590-023-01709-5
