Specialized T cell effector functions depend upon pre-established chromatin state. Cooperativity among PU.1, RUNX1 and BCL11B directs SWI–SNF complex recruitment to carry out chromatin priming at T cell effector loci during early thymic development.
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Liao, J., Hargreaves, D.C. Coordination of transcription factors and SWI–SNF complexes regulates chromatin priming in developing T cells. Nat Immunol 25, 725–727 (2024). https://doi.org/10.1038/s41590-024-01822-z
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DOI: https://doi.org/10.1038/s41590-024-01822-z
