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Gene therapy

A path to efficient gene editing

Nature Medicine volume 24, pages 899–900 (2018)Cite this article

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Signaling by the tumor-suppressor protein p53 antagonizes CRISPR–Cas9 gene editing of human pluripotent stem cells and immortalized human retinal pigment epithelial cells.

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Fig. 1: Induction of p53 contributes to inefficient gene editing in hPSCs.

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  1. Altius Institute for Biomedical Sciences, Seattle, WA, USA

    Fyodor D. Urnov

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  1. Fyodor D. Urnov
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Correspondence to Fyodor D. Urnov.

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Urnov, F.D. A path to efficient gene editing. Nat Med 24, 899–900 (2018). https://doi.org/10.1038/s41591-018-0110-y

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