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CANCER EPIGENETICS

A role for chromatin regulatory dynamics in breast cancer evolution

Enhancer profiling of breast tumors reveals that chromatin regulatory elements contribute to the clonal fitness landscape, treatment resistance and phenotypic divergence.

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Fig. 1: Active enhancers are linked to breast cancer heterogeneity and drug resistance.

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Correspondence to Christina Curtis.

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Probert, C., Curtis, C. A role for chromatin regulatory dynamics in breast cancer evolution. Nat Med 24, 1309–1311 (2018). https://doi.org/10.1038/s41591-018-0182-8

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