Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

GENETIC TESTING

Expanded non-invasive prenatal diagnostics

Nature Medicine volume 25, pages 361–362 (2019)Cite this article

Subjects

Non-invasive prenatal diagnostics allow for the successful identification of paternally inherited and de novo mongenic diseases using circulating cell-free DNA.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Non-invasive prenatal genetic testing for mongenic disease.

References

  1. Zhang, J. et al. Nat. Med. https://doi.org/10.1038/s41591-018-0334-x (2019).

  2. Henkel, M. Zentralbl. Gynaekol. 43, 841 (1919).

  3. Vermeesch, J. R., Voet, T. & Devriendt, K. Nat. Rev. Genet. 17, 643–656 (2016).

    Article  CAS  Google Scholar 

  4. Fan, H. C., Blumenfeld, Y. J., Chitkara, U., Hudgins, L. & Quake, S. R. Proc. Natl Acad. Sci. USA 105, 16266–16271 (2008).

    Article  CAS  Google Scholar 

  5. Bianchi, D. W. Genet. Med. 20, 910–917 (2018).

    Article  CAS  Google Scholar 

  6. Chiu, R. W. et al. Proc. Natl Acad. Sci. USA 105, 20458–20463 (2008).

    Article  CAS  Google Scholar 

  7. Wapner, R. J. et al. Am. J. Obstet. Gynecol. 212, 332 e331–339 (2015).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Genomic Diagnostics, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Nancy B. Spinner

  2. Department of Pathology, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

    Nancy B. Spinner

  3. Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Ian D. Krantz

  4. Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

    Ian D. Krantz

Authors
  1. Nancy B. Spinner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ian D. Krantz
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ian D. Krantz.

Ethics declarations

Competing interests

The author declare no competing interests

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Spinner, N.B., Krantz, I.D. Expanded non-invasive prenatal diagnostics. Nat Med 25, 361–362 (2019). https://doi.org/10.1038/s41591-019-0386-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41591-019-0386-6

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing