The prevalence of aneuploid cells in miscarried human embryos is higher than previously quoted. Genomic imbalances seem to be less tolerated in the embryoblast than the trophoblast, which indicates that allocation of aneuploid cells to the inner cell mass during blastocyst formation might have a detrimental effect on embryo development.
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References
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This is a summary of: Essers, R. et al. Prevalence of chromosomal alterations in first-trimester spontaneous pregnancy loss. Nat. Med. https://doi.org/10.1038/s41591-023-02645-5 (2023).
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The effect of embryonic genome imbalances on pregnancy. Nat Med 29, 3014–3015 (2023). https://doi.org/10.1038/s41591-023-02687-9
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DOI: https://doi.org/10.1038/s41591-023-02687-9
