Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Briefing
  • Published:

New risk score for cardiovascular disease with improved performance

QR4 is a new cardiovascular disease (CVD) risk score developed and evaluated in 16.9 million people that has better performance than other commonly used CVD risk scores. It includes nine new risk factors associated with increased risk of developing CVD (for example, a heart attack or stroke) over the next 10 years.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Predicted 10-year CVD risk with QR4.

References

  1. Goff, D. C. Jr et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J. Am. Coll. Cardiol. 63, 2935–2959 (2014). A guideline that recommends the ASCVD score.

    Article  PubMed  Google Scholar 

  2. Hippisley-Cox, J., Coupland, C. & Brindle, P. Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study. Br. Med. J. 357, j2099 (2017). An original research paper that presents the derivation and validation of QRISK3.

    Article  Google Scholar 

  3. SCORE2 working group & ESC Cardiovascular risk collaboration. Cardiovascular risk collaboration. SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe. Eur. Heart J. 42, 2439–2454 (2021). An original research paper that presents the derivation and validation of SCORE2.

    Article  Google Scholar 

  4. SCORE2-OP working group and ESC Cardiovascular risk collaboration. SCORE2-OP risk prediction algorithms: estimating incident cardiovascular event risk in older persons in four geographical risk regions. Eur. Heart J. 42, 2455–2467 (2021). An original research paper that presents the derivation and validation of SCORE2 in older people.

    Article  Google Scholar 

Download references

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Hippisley-Cox, J. et al. Development and validation of a new algorithm for improved cardiovascular risk prediction. Nat. Med. https://doi.org/10.1038/s41591-024-02905-y (2024).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

New risk score for cardiovascular disease with improved performance. Nat Med (2024). https://doi.org/10.1038/s41591-024-02906-x

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s41591-024-02906-x

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing