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Mapping morphogenesis and mechanics in embryo models

Nature Methods volume 20, pages 1859–1862 (2023)Cite this article

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Recent methodological advances in measurements of geometry and forces in the early embryo and its models are enabling a deeper understanding of the complex interplay of genetics, mechanics and geometry during development.

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Fig. 1: Methods to study morphogenesis and mechanics in embryo models.

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Acknowledgements

We thank the participants of morpho-23 and Kristen Verhey for feedback and discussions. This work was supported by the National Institute of General Medical Sciences (NIGMS 354 R35GM138346), the National Science Foundation (2033654), and the European Molecular Biology Laboratory (EMBL). In writing this we benefited from the morpho-23 program at the Kavli Institute for Theoretical Physics, supported in part by NSF grant PHY-1748958 and Gordon and Betty Moore Foundation grant 2919.02.

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Authors and Affiliations

  1. Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA

    Zong-Yuan Liu & Idse Heemskerk

  2. EMBL Barcelona, Barcelona, Spain

    Vikas Trivedi

  3. EMBL Heidelberg, Developmental Biology Unit, Heidelberg, Germany

    Vikas Trivedi

  4. Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA

    Idse Heemskerk

  5. Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA

    Idse Heemskerk

  6. Center for Cell Plasticity and Organ Design, University of Michigan Medical School, Ann Arbor, MI, USA

    Idse Heemskerk

  7. Department of Physics, University of Michigan, Ann Arbor, MI, USA

    Idse Heemskerk

Authors
  1. Zong-Yuan Liu
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  2. Vikas Trivedi
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  3. Idse Heemskerk
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Contributions

First draft: I.H. Editing: Z.Y.L. and V.T.

Corresponding author

Correspondence to Idse Heemskerk.

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The authors declare no competing interests.

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Liu, ZY., Trivedi, V. & Heemskerk, I. Mapping morphogenesis and mechanics in embryo models. Nat Methods 20, 1859–1862 (2023). https://doi.org/10.1038/s41592-023-02079-4

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