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Same path, different beginnings

An extensive single-cell transcriptomic collection of over 30,000 cells of the developing hippocampus shows that adult hippocampal neurogenesis follows the same differentiation path as embryonic neurogenesis, but the cell of origin differs. This work provides an invaluable resource with important implications for neuronal regeneration.

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References

  1. Gage, F. H. Science 287, 1433–1438 (2000).

    Article  CAS  PubMed  Google Scholar 

  2. Götz, M. & Barde, Y.-A. Neuron 46, 369–372 (2005).

    Article  PubMed  Google Scholar 

  3. Kriegstein, A. & Alvarez-Buylla, A. Annu. Rev. Neurosci. 32, 149–184 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Merkle, F. T. et al. Nat. Neurosci. 17, 207–214 (2014).

    Article  CAS  PubMed  Google Scholar 

  5. Hochgerner, H., Zeisel, A., Lönnerberg, P. & Linnarsson, S. Nat. Neurosci. https://doi.org/10.1038/s41593-017-0056-2 (2018).

    PubMed  Google Scholar 

  6. Shin, J. et al. Cell. Stem Cell. 17, 360–372 (2015).

    Article  CAS  PubMed  Google Scholar 

  7. Dulken, B. W., Leeman, D. S., Boutet, S. C., Hebestreit, K. & Brunet, A. Cell Rep. 18, 777–790 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Llorens-Bobadilla, E. et al. Cell. Stem Cell. 17, 329–340 (2015).

    Article  CAS  PubMed  Google Scholar 

  9. Eckert, D., Buhl, S., Weber, S., Jäger, R. & Schorle, H. Genome Biol. 6, 246 (2005).

    Article  PubMed  PubMed Central  Google Scholar 

  10. McKenna, A. et al. Science 353, aaf7907 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Lazarov, O., Mattson, M. P., Peterson, D. A., Pimplikar, S. W. & van Praag, H. Trends Neurosci. 33, 569–579 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Friedmann-Morvinski, D. et al. Science 338, 1080–1084 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Wu, K.-Y. et al. Cell. Res. 26, 645–654 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  14. Spalding, K. L. et al. Cell 153, 1219–1227 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Quiñones-Hinojosa, A. et al. J. Comp. Neurol. 494, 415–434 (2006).

    Article  PubMed  Google Scholar 

  16. Pollen, A. A. et al. Cell 163, 55–67 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Anne Brunet.

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Dulken, B.W., Brunet, A. Same path, different beginnings. Nat Neurosci 21, 159–160 (2018). https://doi.org/10.1038/s41593-017-0063-3

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