Geneticists are pushing for ever-greater sample sizes to gain insight into the genetic variation that contributes to psychiatric disorders. Two new genome-wide association studies leverage this approach to provide broad, population-level perspectives on the genetic basis for major depressive disorder and the shared genetic risk that underlies multiple disorders.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
A comprehensive gene-centric pleiotropic association analysis for 14 psychiatric disorders with GWAS summary statistics
BMC Medicine Open Access 13 December 2021
-
Genome-wide association study of psychiatric and substance use comorbidity in Mexican individuals
Scientific Reports Open Access 24 March 2021
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Schork, A. J. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-018-0320-0 (2019).
Howard, D. M. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-018-0326-7 (2019).
Cross-Disorder Group of the Psychiatric Genomics Consortium. Lancet 381, 1371–1379 (2013).
Lahey, B. B. et al. J. Abnorm. Psychol. 121, 971–977 (2012).
Lahey, B. B., Krueger, R. F., Rathouz, P. J., Waldman, I. D. & Zald, D. H. World Psychiatry 16, 142–144 (2017).
Howard, D. M. et al. Nat. Commun. 9, 1470 (2018).
Kendler, K. S. et al. Psychol. Med. https://doi.org/10.1017/S003329171800377X (2018).
Acknowledgements
I thank N. J. Cox, K. S. Kendler, M. C. Aldrich, and T. L. Davis for thoughtful discussion and insightful feedback on this article.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Davis, L.K. Common knowledge: shared genetics in psychiatry. Nat Neurosci 22, 331–332 (2019). https://doi.org/10.1038/s41593-019-0346-y
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41593-019-0346-y