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NEUROIMMUNOLOGY

Checking macrophages at the border

The CNS harbors distinct subsets of macrophages, including parenchymal microglia and macrophages residing at border regions (for example, meninges and the choroid plexus). In this issue of Nature Neuroscience, Van Hove and colleagues elegantly demonstrate the diversity and dynamics of non-parenchymal macrophages and identify a unique microglial subtype within the choroid plexus.

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Fig. 1: Profiling CNS macrophages.

References

  1. Colonna, M. & Butovsky, O. Annu. Rev. Immunol. 35, 441–468 (2017).

    Article  CAS  Google Scholar 

  2. Jordao, M. J. C. et al. Science 363, eaat7554 (2019).

    Article  Google Scholar 

  3. Mrdjen, D. et al. Immunity 380–395.e6 (2018).

  4. Goldmann, T. et al. Nat. Immunol. 17, 797–805 (2016).

    Article  CAS  Google Scholar 

  5. Van Hove, H. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-019-0393-4 (2019).

    Article  PubMed  Google Scholar 

  6. Buttgereit, A. et al. Nat. Immunol. 17, 1397–1406 (2016).

    Article  CAS  Google Scholar 

  7. Butovsky, O. et al. Nat. Neurosci. 17, 131–143 (2014).

    Article  CAS  Google Scholar 

  8. Ling, E. A., Kaur, C. & Lu, J. Microsc. Res. Tech. 41, 43–56 (1998).

    Article  CAS  Google Scholar 

  9. Deczkowska, A. et al. Cell 173, 1073–1081 (2018).

    Article  CAS  Google Scholar 

  10. Ginhoux, F. et al. Science 330, 841–845 (2010).

    Article  CAS  Google Scholar 

  11. Mundt, S. et al. Sci. Immunol. 4, eaau8380 (2019).

    Article  Google Scholar 

  12. Rua, R. et al. Nat. Immunol. 20, 407–419 (2019).

    Article  CAS  Google Scholar 

  13. Hammond, T. R. et al. Immunity 50, 253–271.e6 (2019).

    Article  CAS  Google Scholar 

  14. Masuda, T. et al. Nature 566, 388–392 (2019).

    Article  CAS  Google Scholar 

  15. Kierdorf, K. et al. Nat. Neurosci. 16, 273–280 (2013).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Melanie Greter.

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Utz, S.G., Greter, M. Checking macrophages at the border. Nat Neurosci 22, 848–850 (2019). https://doi.org/10.1038/s41593-019-0411-6

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