Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

NEUROIMMUNOLOGY

The dark side of antiviral T cell responses

Nature Neuroscience volume 22, pages 1199–1200 (2019)Cite this article

Subjects

Mosquito-borne virus infections, such as West Nile and Zika, have debilitating cognitive effects that persist despite recovery from encephalitis. Garber et al. identify mechanisms by which antiviral T cell persistence after recovery from infection leads to impairments in cognition via virus-specific mediation of microglial synapse elimination.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Garber, C. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-019-0427-y (2019).

  2. Vasek, M. J. et al. Nature 534, 538–543 (2016).

    Article  CAS  Google Scholar 

  3. Kim, I. J., Beck, H. N., Lein, P. J. & Higgins, D. J. Neurosci. 22, 4530–4539 (2002).

    Article  CAS  Google Scholar 

  4. Filiano, A. J. et al. Nature 535, 425–429 (2016).

    Article  CAS  Google Scholar 

  5. Monteiro, S. et al. Transl. Psychiatry 6, e707 (2016).

    Article  CAS  Google Scholar 

  6. Readhead, B. et al. Neuron 99, 64–82.e7 (2018).

    Article  CAS  Google Scholar 

  7. Shi, Q. et al. Sci. Transl. Med. 9, eaaf6295 (2017).

    Article  Google Scholar 

  8. Hong, S. et al. Science 352, 712–716 (2016).

    Article  CAS  Google Scholar 

  9. Di Liberto, G. et al. Cell 175, 458–471.e19 (2018).

    Article  Google Scholar 

  10. Kreutzfeldt, M. et al. J. Exp. Med. 210, 2087–2103 (2013).

    Article  CAS  Google Scholar 

  11. Krukowski, K. et al. Int. J. Mol. Sci. 19, 3753 (2018).

    Article  Google Scholar 

  12. Sospedra, M. & Martin, R. Annu. Rev. Immunol. 23, 683–747 (2005).

    Article  CAS  Google Scholar 

  13. Chevalier, G. et al. PLoS Pathog. 7, e1002393 (2011).

    Article  CAS  Google Scholar 

  14. Liblau, R. S., Gonzalez-Dunia, D., Wiendl, H. & Zipp, F. Trends Neurosci. 36, 315–324 (2013).

    Article  CAS  Google Scholar 

  15. Bien, C. G. et al. Brain 135, 1622–1638 (2012).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA, USA

    Karen Krukowski & Susanna Rosi

  2. Brain and Spinal Injury Center, University of California, San Francisco, San Francisco, CA, USA

    Karen Krukowski & Susanna Rosi

  3. Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA

    Susanna Rosi

  4. Weill Institute for Neuroscience, University of California San Francisco, San Francisco, CA, USA

    Susanna Rosi

  5. Kavli Institute of Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, USA

    Susanna Rosi

Authors
  1. Karen Krukowski
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Susanna Rosi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Susanna Rosi.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Krukowski, K., Rosi, S. The dark side of antiviral T cell responses. Nat Neurosci 22, 1199–1200 (2019). https://doi.org/10.1038/s41593-019-0454-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41593-019-0454-8

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing