Hardening of the arteries (atherosclerosis) was linked to dementia long ago, but subsequently, Alzheimer’s plaques and tangles have received more attention. A new proteome-wide association study unveils molecular links between intracranial atherosclerosis and dementia, independent of other pathologies, providing new evidence for one of the oldest suspected causes of dementia.
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Iadecola, C. Revisiting atherosclerosis and dementia. Nat Neurosci 23, 691–692 (2020). https://doi.org/10.1038/s41593-020-0626-6
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DOI: https://doi.org/10.1038/s41593-020-0626-6