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ALZHEIMER’S DISEASE AND MEMORY

Extra neural ensemble disrupts memory recall

Nature Neuroscience volume 23, pages 905–907 (2020)Cite this article

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Poll and colleagues examined the historical activity of hippocampal CA1 neurons during learning and memory recall using longitudinal two-photon in vivo imaging, providing evidence that extra neural ensemble activity disrupts memory recall in a mouse model of early Alzheimer’s disease.

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Fig. 1: Extra neural ensemble activity beyond memory-related neural ensembles disrupts recall of contextual fear memory in APP/PS1 mice.

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Authors and Affiliations

  1. Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Ryang Kim, Naoki Yamamoto & Takashi Kitamura

  2. Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Takashi Kitamura

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  1. Ryang Kim
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  2. Naoki Yamamoto
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  3. Takashi Kitamura
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Correspondence to Takashi Kitamura.

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The authors declare no competing interests.

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Kim, R., Yamamoto, N. & Kitamura, T. Extra neural ensemble disrupts memory recall. Nat Neurosci 23, 905–907 (2020). https://doi.org/10.1038/s41593-020-0673-z

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