A new cell state of disease-associated oligodendrocytes (DOLs) has been identified, which presents a transcriptional program that is probably driven by neuroinflammation and is shared among different non-immune glial cells across multiple pathologies of the central nervous system.
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This is a summary of: Kenigsbuch, M. et al. A shared disease-associated oligodendrocyte signature among multiple CNS pathologies. Nature https://doi.org/10.1038/s41593-022-01104-7 (2022).
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Changes in the expression profiles of oligodendrocytes are shared in different brain pathologies. Nat Neurosci 25, 845–846 (2022). https://doi.org/10.1038/s41593-022-01105-6
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DOI: https://doi.org/10.1038/s41593-022-01105-6
