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BRAIN DEVELOPMENT

Neurogenic–angiogenic synchrony via lactate

Nature Neuroscience volume 25, pages 839–840 (2022)Cite this article

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During cortical development, the generation of neurons from progenitors coincides with increasing vascularization and oxygen levels in the fetal brain and the transition from anaerobic to aerobic metabolism. Dong et al. identify lactate, a metabolite of anaerobic glycolysis, as a multifunctional regulator that coordinates synchrony of cortical neurogenesis and angiogenesis.

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Fig. 1: Lactate signaling coordinates synchrony of cortical neurogenesis and angiogenesis.

References

  1. Dong, X. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-022-01093-7 (2022).

    Article  PubMed  Google Scholar 

  2. Fame, R. M., Shannon, M. L., Chau, K. F., Head, J. P. & Lehtinen, M. K. Development 146, dev182857 (2019).

    Article  CAS  Google Scholar 

  3. Barros, L. F. Trends Neurosci. 36, 396–404 (2013).

    Article  CAS  Google Scholar 

  4. Li, A. et al. Angiogenesis 8, 63–71 (2005).

    Article  CAS  Google Scholar 

  5. Khacho, M. et al. Cell Stem Cell 19, 232–247 (2016).

    Article  CAS  Google Scholar 

  6. Vasudevan, A., Long, J. E., Crandall, J. E., Rubenstein, J. L. & Bhide, P. G. Nat. Neurosci. 11, 429–439 (2008).

    Article  CAS  Google Scholar 

  7. Keil, J. M. et al. Nat. Commun. 11, 3839 (2020).

    Article  CAS  Google Scholar 

  8. Stubbs, D. et al. Cereb. Cortex 19, i32–i41 (2009).

    Article  Google Scholar 

  9. Paredes, I., Himmels, P. & Ruiz de Almodóvar, C. Dev. Cell 45, 10–32 (2018).

    Article  CAS  Google Scholar 

  10. Swinnen, N. et al. Glia 61, 150–163 (2013).

    Article  Google Scholar 

  11. Shi, L., Qalieh, A., Lam, M. M., Keil, J. M. & Kwan, K. Y. Nat. Commun. 10, 2588 (2019).

    Article  Google Scholar 

  12. Penna, E., Mangum, J. M., Shepherd, H., Martínez-Cerdeño, V. & Noctor, S. C. Cereb. Cortex 31, 2139–2155 (2021).

    Article  Google Scholar 

  13. Doyle, D. Z. et al. Proc. Natl Acad. Sci. USA 118, e2100686118 (2021).

    Article  CAS  Google Scholar 

  14. Monsorno, K., Buckinx, A. & Paolicelli, R. C. Trends Endocrinol. Metab. 33, 186–195 (2022).

    Article  CAS  Google Scholar 

  15. Fame, R. M. & Lehtinen, M. K. Front. Cell Dev. Biol. 9, 780207 (2021).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Michigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, MI, USA

    Daniel Z. Doyle & Kenneth Y. Kwan

  2. Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA

    Daniel Z. Doyle & Kenneth Y. Kwan

  3. Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA

    Daniel Z. Doyle & Kenneth Y. Kwan

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  1. Daniel Z. Doyle
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  2. Kenneth Y. Kwan
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Correspondence to Kenneth Y. Kwan.

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Doyle, D.Z., Kwan, K.Y. Neurogenic–angiogenic synchrony via lactate. Nat Neurosci 25, 839–840 (2022). https://doi.org/10.1038/s41593-022-01111-8

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