Epilepsy is the most common childhood neurological disease, and nearly 20% of affected children develop drug-resistant childhood epilepsy (DRCE). Using single-cell analysis methods, Kumar et al. have identified pro-inflammatory interactions between microglia and T cells in brain tissue from individuals with DRCE. This work may help to identify therapeutic targets for DRCE.
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References
Annegers, J. F., Hauser, W. A., Lee, J. R. & Rocca, W. A. Epilepsia 36, 327–333 (1995).
Shinnar, S. & Pellock, J. M. J. Child Neurol. 17, S4–S17 (2002).
Fisher, R. S. et al. Epilepsia 46, 470–472 (2005).
Rosati, A., De Masi, S. & Guerrini, R. CNS Drugs 29, 847–863 (2015).
Orsini, A. et al. Epilepsy Res. 172, 106588 (2021).
Zimmer, T. S. et al. Neuropathol. Appl. Neurobiol. 47, 826–839 (2021).
Kumar, P. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-022-01095-5 (2022).
Giladi, A. et al. Nat. Biotechnol. 38, 629–637 (2020).
Rothhammer, V. et al. Nature 557, 724–728 (2018).
Clark, I. C. et al. Science 372, eabf1230 (2021).
Mount, C. W., Yalçın, B., Cunliffe-Koehler, K., Sundaresh, S. & Monje, M. eLife 8, e49291 (2019).
Steinman, L. Nat. Rev. Drug Discov. 4, 510–518 (2005).
Bhalla, D., Godet, B., Druet-Cabanac, M. & Preux, P. M. Expert Rev. Neurother. 11, 861–876 (2011).
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Andersen, B.M., Quintana, F.J. Neuro-immune crosstalk in drug-resistant epilepsy. Nat Neurosci 25, 843–844 (2022). https://doi.org/10.1038/s41593-022-01112-7
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DOI: https://doi.org/10.1038/s41593-022-01112-7