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EPILEPSY

Neuro-immune crosstalk in drug-resistant epilepsy

Epilepsy is the most common childhood neurological disease, and nearly 20% of affected children develop drug-resistant childhood epilepsy (DRCE). Using single-cell analysis methods, Kumar et al. have identified pro-inflammatory interactions between microglia and T cells in brain tissue from individuals with DRCE. This work may help to identify therapeutic targets for DRCE.

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Fig. 1: Scheme of single-cell analysis of the neuroinflammatory microenvironment of drug-resistant lesions in childhood epilepsy.

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Correspondence to Francisco J. Quintana.

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Andersen, B.M., Quintana, F.J. Neuro-immune crosstalk in drug-resistant epilepsy. Nat Neurosci 25, 843–844 (2022). https://doi.org/10.1038/s41593-022-01112-7

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