Transcripts with highly complementary sequences can target microRNAs (miRNAs) for degradation, but the physiological relevance of target-directed miRNA degradation (TDMD) has remained unclear. Bitetti et al. now identify a conserved vertebrate RNA that induces TDMD in the cerebellum of zebrafish and mouse to promote wild-type animal behaviors.
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de la Mata, M., Großhans, H. Turning the table on miRNAs. Nat Struct Mol Biol 25, 195–197 (2018). https://doi.org/10.1038/s41594-018-0040-x
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DOI: https://doi.org/10.1038/s41594-018-0040-x