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DNA damage response

TAp63 as a guardian of female germ line integrity

Nature Structural & Molecular Biology volume 25, pages 201–202 (2018)Cite this article

A new study reveals how the oocyte-specific transcription factor TAp63 ensures female germ line fidelity and describes approaches to circumvent premature ovarian insufficiency in women receiving cytotoxic chemotherapy.

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Fig. 1: TAp63 monitors DNA damage in a prolonged, post-pachytene checkpoint.

Kim Caesar/Springer Nature.

Fig. 2: DNA damage response and TAp63 dynamics in oocytes.

Kim Caesar/Springer Nature.

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Authors and Affiliations

  1. Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Sciences Center, Houston, TX, USA

    Wa Xian

  2. Department of Biology and Biochemistry, University of Houston, Houston, TX, USA

    Frank McKeon

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  1. Wa Xian
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  2. Frank McKeon
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Correspondence to Wa Xian.

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Xian, W., McKeon, F. TAp63 as a guardian of female germ line integrity. Nat Struct Mol Biol 25, 201–202 (2018). https://doi.org/10.1038/s41594-018-0041-9

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