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T-box RNA gets boxed

Nature Structural & Molecular Biology volume 26, pages 1081–1083 (2019)Cite this article

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Bacterial T-boxes are regulatory mRNA regions that control the transcription or translation of factors involved in amino acid supply. T-boxes act by directly binding to non-aminoacylated tRNA in response to amino acid starvation. Three studies now capture three-dimensional structures of tRNA–T-box complexes and reveal a set of RNA features that are required for the recognition of specific tRNAs and modulation of gene expression.

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Fig. 1: Transcriptional control mechanism and overall architecture of T-boxes.
Fig. 2: Three-dimensional structures of T-boxes.

References

  1. Dale, B. A. & Nester, E. W. J. Bacteriol. 108, 586–588 (1971).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Nass, G. & Neidhardt, F. C. Biochim. Biophys. Acta 134, 347–359 (1967).

    Article  CAS  Google Scholar 

  3. Henkin, T. M., Glass, B. L. & Grundy, F. J. J. Bacteriol. 174, 1299–1306 (1992).

    Article  CAS  Google Scholar 

  4. Putzer, H., Gendron, N. & Grunberg-Manago, M. EMBO J. 11, 3117–3127 (1992).

    Article  CAS  Google Scholar 

  5. Grandoni, J. A., Zahler, S. A. & Calvo, J. M. J. Bacteriol. 174, 3212–3219 (1992).

    Article  CAS  Google Scholar 

  6. Grundy, F. J. & Henkin, T. M. Cell 74, 475–482 (1993).

    Article  CAS  Google Scholar 

  7. Henkin, T. M. Biochim. Biophys. Acta 1839, 959–963 (2014).

    Article  CAS  Google Scholar 

  8. Li, S. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-019-0326-7 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Zhang, J. & Ferré-D’Amaré, A. R. Nature 500, 363–366 (2013).

    Article  CAS  Google Scholar 

  10. Grigg, J. C. & Ke, A. Structure 21, 2025–2032 (2013).

    Article  CAS  Google Scholar 

  11. Battaglia, R. A., Grigg, J. C. & Ke, A. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-019-0327-6 (2019).

    Article  PubMed  Google Scholar 

  12. Suddala, K. C. & Zhang, J. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-019-0335-6 (2019).

    Article  PubMed  Google Scholar 

  13. Zhang, J. & Ferré-D’Amaré, A. R. Mol. Cell 55, 148–155 (2014).

    Article  CAS  Google Scholar 

  14. Nahvi, A. et al. Chem. Biol. 9, 1043 (2002).

    Article  CAS  Google Scholar 

  15. Winkler, W., Nahvi, A. & Breaker, R. R. Nature 419, 952–956 (2002).

    Article  CAS  Google Scholar 

  16. Mironov, A. S. et al. Cell 111, 747–756 (2002).

    Article  CAS  Google Scholar 

  17. Serganov, A. & Nudler, E. Cell 152, 17–24 (2013).

    Article  CAS  Google Scholar 

  18. Ren, A., Micura, R. & Patel, D. J. Curr. Opin. Chem. Biol. 41, 71–83 (2017).

    Article  CAS  Google Scholar 

  19. Korostelev, A., Trakhanov, S., Laurberg, M. & Noller, H. F. Cell 126, 1065–1077 (2006).

    Article  CAS  Google Scholar 

  20. Brown, A., Fernández, I. S., Gordiyenko, Y. & Ramakrishnan, V. Nature 534, 277–280 (2016).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA

    Jacob W. Weaver & Alexander Serganov

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  1. Jacob W. Weaver
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  2. Alexander Serganov
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Correspondence to Alexander Serganov.

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The authors declare no competing interests.

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Weaver, J.W., Serganov, A. T-box RNA gets boxed. Nat Struct Mol Biol 26, 1081–1083 (2019). https://doi.org/10.1038/s41594-019-0340-9

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