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Ion channels

Insights into stoichiometry and gating of heteromeric LRRC8A–LRRC8C volume-regulated anion channels

Volume-regulated anion channels (VRACs) are critical for cell volume regulation, neuron–glia interaction, metabolism, and immunity. They are formed as heteromers of LRRC8 proteins with unknown stoichiometry. Two papers now reveal the structures of heteromeric LRRC8A and LRRC8C channels, providing insights into channel assembly and gating.

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Fig. 1: Representative structures of heterohexameric LRRC8A–LRRC8C channels.

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Acknowledgements

Research in the laboratory of Z.Q. is funded by the National Institutes of Health (NIH; grants R35GM124824 and R01NS118014).

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Correspondence to Zhaozhu Qiu.

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Hagino, T., Qiu, Z. Insights into stoichiometry and gating of heteromeric LRRC8A–LRRC8C volume-regulated anion channels. Nat Struct Mol Biol 30, 714–716 (2023). https://doi.org/10.1038/s41594-023-01012-9

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