A study on a yeast model explores how ssDNA gaps induce cell death and genomic instability, implicating Rad9 and Rad51 in gap repair and protection. Gaps forming secondary structures trigger chromosome fragility, deletions, rearrangements, or cell death pathways, showing how gaps are a vulnerability in cancer cells with opportunity for selective targeting.
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This work was supported by R01 CA254037.
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Whalen, J.M., Cantor, S.B. Unveiling the toxicity of single-stranded DNA gaps through a yeast model. Nat Struct Mol Biol 30, 870–872 (2023). https://doi.org/10.1038/s41594-023-01031-6
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DOI: https://doi.org/10.1038/s41594-023-01031-6
