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Pre-mRNA splicing

Illuminating the role of chaperones in spliceosome biogenesis and recycling

Nature Structural & Molecular Biology (2024)Cite this article

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Spliceosome biogenesis and recycling remains a largely unexplored area. Two papers now reveal how protein chaperones remodel the 20S U5 snRNP, leading to formation of the U4/U6.U5 tri-snRNP.

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Fig. 1: Schematic of U5 snRNP during the transition from the 20S U5 snRNP to the U4/U6.U5 tri-snRNP.

References

  1. Kastner, B., Will, C. L., Stark, H. & Luhrmann, R. Cold Spring Harb. Perspect. Biol. 11, a032417 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Bach, M. & Luhrmann, R. Biochim. Biophys. Acta 1088, 139–143 (1991).

    Article  CAS  PubMed  Google Scholar 

  3. Achsel, T., Ahrens, K., Brahms, H., Teigelkamp, S. & Luhrmann, R. Mol. Cell Biol. 18, 6756–6766 (1998).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Malinova, A. et al. J. Cell Biol. 216, 1579–1596 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Klimesova, K. et al. Nat. Commun. 12, 3646 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Laggerbauer, B. et al. RNA 11, 598–608 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Riabov Bassat, D. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-024-01243-4 (2024).

  8. Schneider, S. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-024-01250-5 (2024).

  9. Nielsen, T. K., Liu, S., Luhrmann, R. & Ficner, R. J. Mol. Biol. 369, 902–908 (2007).

    Article  CAS  PubMed  Google Scholar 

  10. Galej, W. P., Oubridge, C., Newman, A. J. & Nagai, K. Nature 493, 638–643 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Weber, G. et al. Genes Dev. 27, 525–540 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Agafonov, D. E. et al. Science 351, 1416–1420 (2016).

    Article  CAS  PubMed  Google Scholar 

  13. Charenton, C., Wilkinson, M. E. & Nagai, K. Science 364, 362–367 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Bergfort, A. et al. Nucleic Acids Res. 50, 2938–2958 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Grainger, R. J. & Beggs, J. D. RNA 11, 533–557 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The author acknowledges UK Medical Research Council grant MC_UP_1201/30 for funding.

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  1. MRC Laboratory of Molecular Biology, Cambridge, UK

    Suyang Zhang

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  1. Suyang Zhang
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Correspondence to Suyang Zhang.

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Zhang, S. Illuminating the role of chaperones in spliceosome biogenesis and recycling. Nat Struct Mol Biol (2024). https://doi.org/10.1038/s41594-024-01293-8

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