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ENDOTHELIAL METABOLISM

Pentose phosphate pathway drives vascular maturation

Nature Metabolism volume 4, pages 15–16 (2022)Cite this article

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Facchinello, Astone et al. demonstrate a role for the endothelial oxidative pentose phosphate pathway (oxPPP) in promoting vascular mural cell coverage and maturation during early development by regulating elastin expression. This mechanism establishes a critical role for oxPPP in the formation of the vascular system.

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Fig. 1: Endothelial oxPPP shunts development towards vascular maturation through elastin.

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Acknowledgements

The work was supported by NIH HL071625 to TB and NIH R56HL148025 to OAC.

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Authors and Affiliations

  1. Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA

    Olga A. Cherepanova

  2. Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA

    Tatiana V. Byzova

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  1. Olga A. Cherepanova
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  2. Tatiana V. Byzova
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Correspondence to Olga A. Cherepanova or Tatiana V. Byzova.

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The authors declare no competing interests.

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Cherepanova, O.A., Byzova, T.V. Pentose phosphate pathway drives vascular maturation. Nat Metab 4, 15–16 (2022). https://doi.org/10.1038/s42255-021-00512-6

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