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Cancer metabolism

Methionine and H2S alter cancer–immune dialogue

Nature Metabolism volume 5, pages 1456–1458 (2023)Cite this article

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Methionine restriction modulates tumour growth and ageing processes through its influence on diverse metabolic processes. Ji et al. demonstrate that methionine restriction compromises production of hydrogen sulfide (H2S), which impairs H2S-mediated immune signalling and results in increased cancer progression in immunocompetent mice.

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Fig. 1: The effect of methionine restriction differs according to immunocompromised versus immunocompetent status.

References

  1. Wang, T. J. et al. Nat. Med. 17, 448–453 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Handzlik, M. K. et al. Nature 614, 118–124 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Ren, B. et al. Redox Biol. 41, 101940 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Bárcena, C. et al. Cell Rep. 24, 2392–2403 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Tönjes, M. et al. Nat. Med. 19, 901–908 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Krall, A. S., Xu, S., Graeber, T. G., Braas, D. & Christofk, H. R. Nat. Commun. 7, 11457 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Ji, M. et al. Nat. Metab. https://doi.org/10.1038/s42255-023-00854-3 (2023).

    Article  PubMed  Google Scholar 

  8. Gao, X. et al. Nature 572, 397–401 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Miller, T. W. et al. J. Biol. Chem. 287, 4211–4221 (2012).

    Article  CAS  PubMed  Google Scholar 

  10. Papapetropoulos, A. et al. Proc. Natl Acad. Sci. USA 106, 21972–21977 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Sen, N. et al. Mol. Cell 45, 13–24 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ma, E. H. et al. Cell Metab. 25, 345–357 (2017).

    Article  CAS  PubMed  Google Scholar 

  13. Roy, D. G. et al. Cell Metab. 31, 250–266.e9 (2020).

    Article  CAS  PubMed  Google Scholar 

  14. Gensollen, T., Iyer, S. S., Kasper, D. L. & Blumberg, R. S. Science 352, 539–544 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Li, T. et al. Gut 72, 501–511 (2023).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA

    Emeline Joulia & Christian M. Metallo

  2. Department of Bioengineering, University of California San Diego, La Jolla, CA, USA

    Christian M. Metallo

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  1. Emeline Joulia
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  2. Christian M. Metallo
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Correspondence to Christian M. Metallo.

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The authors declare no competing interests.

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Joulia, E., Metallo, C.M. Methionine and H2S alter cancer–immune dialogue. Nat Metab 5, 1456–1458 (2023). https://doi.org/10.1038/s42255-023-00862-3

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