Our analysis of the spatiotemporal transcriptional features of human ovarian aging at the single-cell level identified the DNA damage response as a fundamental attribute in oocyte senescence. FOXP1, a gatekeeper both in granulosa and in theca and stroma cellular senescence, can be activated by quercetin treatment to delay ovarian aging.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Davis, S. R., Pinkerton, J., Santoro, N. & Simoncini, T. Menopause-biology, consequences, supportive care, and therapeutic options. Cell 186, 4038–4058 (2023). A review that presents ovarian aging as the pacemaker of female aging.
Laisk, T. et al. Demographic and evolutionary trends in ovarian function and aging. Hum. Reprod. Update. 25, 34–50 (2019). A review that presents the importance of ovarian aging research.
Fan, X. et al. Single-cell reconstruction of follicular remodeling in the human adult ovary. Nat. Commun. 18, 3164 (2019). This paper reports human ovarian cell types.
Lu, H. et al. Aging hallmarks of the primate ovary revealed by spatiotemporal transcriptomics. Protein Cell https://doi.org/10.1093/procel/pwad063 (2023). This paper presents hallmarks of primate ovarian aging.
Shixuan W. (ed.) Ovarian Aging (Springer, 2023). This book presents the clinical and basic research progress of ovarian aging.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Wu, M. et al. Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1. Nat. Aging https://doi.org/10.1038/s43587-024-00607-1 (2024).
Rights and permissions
About this article
Cite this article
FOXP1 is a gatekeeper of cellular senescence with ovarian aging. Nat Aging 4, 451–452 (2024). https://doi.org/10.1038/s43587-024-00608-0
Published:
Issue Date:
DOI: https://doi.org/10.1038/s43587-024-00608-0