Skeletal muscle is a highly heterogenous tissue that comprises multiple cell types. Leveraging single-cell and single-nucleus experiments, we systematically mapped the cellular and molecular changes across different skeletal muscle compartments with age. We identify neuromuscular-junction accessory nuclei that may be pivotal in mitigating denervation and uncovered differences between myofiber and myonucleus aging.
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This is a summary of: Kedlian, V. R. et al. Human skeletal muscle aging atlas. Nat. Aging, https://doi.org/10.1038/s43587-024-00613-3 (2024).
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Systematic analysis of muscle aging using joint single-cell and single-nucleus sequencing. Nat Aging (2024). https://doi.org/10.1038/s43587-024-00629-9
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DOI: https://doi.org/10.1038/s43587-024-00629-9
