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BIOCATALYSIS

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Converting simple building blocks into enantiopure amines is an important synthetic transformation. Now, a biocatalyst has been discovered that catalyses two reductive steps within a single active site, and can synthesize a range of amine targets from ene–one starting materials.

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Fig. 1: The bacterial EneIRED biocatalyst catalyses two NADPH-dependent reductions in a single active site.

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Correspondence to Dominic J. Campopiano.

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Herrera, M.A., Campopiano, D.J. Buy one, get one free. Nat. Synth 1, 420–421 (2022). https://doi.org/10.1038/s44160-022-00092-7

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