Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Supramolecular chemistry

Synthesis of l-cyclodextrins

Nature Synthesis (2024)Cite this article

Subjects

d-cyclodextrins are naturally occurring macrocyclic oligosaccharides that act as hosts for hydrophobic guests and are produced on a multi-tonne scale. Now, using chemical synthesis, mirror-image cyclodextrins are produced from l- instead of d-glucose units.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: l-cyclodextrins (l-CDs) are enantiomers of the well-known d-CDs.

References

  1. Young, B. E., Kundu, N. & Sczepanski, J. T. Chem. Eur. J. 34, 7981–7990 (2019).

    Article  Google Scholar 

  2. Lander, A. J., Jin, Y. & Luk, L. Y. P. Chembiochem 24, e202200537 (2023).

    Article  CAS  PubMed  Google Scholar 

  3. Boulineau, F. P. & Wei, A. J. Org. Chem. 69, 3391–3399 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Del Valle, E. M. M. Process Biochem. 39, 1033–1176 (2004).

    Article  CAS  Google Scholar 

  5. Rekharsky, M. V. & Inoue, Y. Chem. Rev. 98, 1875–1917 (1998).

    Article  CAS  PubMed  Google Scholar 

  6. Ikatu, D. et al. Science 364, 674–677 (2019).

    Article  Google Scholar 

  7. Nakagawa, T., Ueno, K., Kashiwa, M. & Watanabe, J. Tetrahedron Lett. 35, 1921–1924 (1994).

    Article  CAS  Google Scholar 

  8. Wakao, M., Fukase, K. & Kusumoto, S. J. Org. Chem. 67, 8182–8190 (2002).

    Article  CAS  PubMed  Google Scholar 

  9. Erichsen, A., Peters, G. H. & Beeren, S. R. J. Am. Chem. Soc. 145, 4882–4891 (2023).

    Article  CAS  PubMed  Google Scholar 

  10. Wu, Y. et al. Nat. Synth. https://doi.org/10.1038/s44160-024-00495-8 (2024).

    Article  Google Scholar 

Download references

Author information

Author notes

  1. Twitter / X: @BeerenLab

Authors and Affiliations

  1. Department of Chemistry, Technical University of Denmark, Kongens Lyngby, Denmark

    Sophie R. Beeren

Authors
  1. Sophie R. Beeren
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sophie R. Beeren.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Beeren, S.R. Synthesis of l-cyclodextrins. Nat. Synth (2024). https://doi.org/10.1038/s44160-024-00512-w

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s44160-024-00512-w

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing