Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Parenchymal border macrophages

An unnoticed player overseeing CSF flux

Nature Cardiovascular Research volume 1, pages 1114–1115 (2022)Cite this article

Subjects

A new study shows that brain-resident parenchymal border macrophages (PBMs) maintain perivascular extracellular matrix composition by the release of matrix metalloproteinases. Depletion of PBMs suppressed glymphatic fluid transport, underscoring their responsibility for perivascular space homeostasis and brain protein clearance.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Functions and subtypes of parenchymal border macrophages (PBMs).

References

  1. Papadopoulos, Z., Herz, J. & Kipnis, J. J. Immunol. 204, 286–293 (2020).

    Article  CAS  Google Scholar 

  2. Karam, M., Janbon, H., Malkinson, G. & Brunet, I. J. Cereb. Blood Flow Metab. 42, 1797–1812 (2022).

    Article  CAS  Google Scholar 

  3. Drieu, A. et al. Nature 611, 585–593 (2022).

    Article  CAS  Google Scholar 

  4. Mato, M., Ookawara, S. & Kurihara, K. Am. J. Anat. 157, 329–332 (1980).

    Article  CAS  Google Scholar 

  5. Ousman, S. S. & Kubes, P. Nat. Neurosci. 15, 1096–1101 (2012).

    Article  CAS  Google Scholar 

  6. Park, L. et al. Circ. Res. 121, 258–269 (2017).

    Article  CAS  Google Scholar 

  7. Li, Q. & Barres, B. A. Nat. Rev. Immunol. 18, 225–242 (2018).

    Article  CAS  Google Scholar 

  8. Yunna, C., Mengru, H., Lei, W. & Weidong, C. Macrophage M1/M2 polarization. Eur. J. Pharmacol. 877, 173090 (2020).

    Article  Google Scholar 

  9. Campbell, R. A., Docherty, M.-H., Ferenbach, D. A. & Mylonas, K. J. Front. Immunol. 12, 700790 (2021).

    Article  CAS  Google Scholar 

  10. Clarke, L. E. et al. Proc. Natl Acad. Sci. USA 115, E1896–E1905 (2018).

    CAS  Google Scholar 

  11. Kress, B. T. et al. Ann. Neurol. 76, 845–861 (2014).

    Article  CAS  Google Scholar 

  12. Hawkes, C. A. & McLaurin, J. Proc. Natl Acad. Sci. USA 106, 1261–1266 (2009).

    Article  CAS  Google Scholar 

  13. Elkington, P. T., Green, J. A. & Friedland, J. S. Methods Mol. Biol. 531, 253–265 (2009).

    Article  CAS  Google Scholar 

  14. Thanopoulou, K., Fragkouli, A., Stylianopoulou, F. & Georgopoulos, S. Proc. Natl Acad. Sci. USA 107, 20816–20821 (2010).

    Article  CAS  Google Scholar 

  15. Rasmussen, M. K., Mestre, H. & Nedergaard, M. Lancet Neurol. 17, 1016–1024 (2018).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank D. Xue for expert graphical support. This project has received funding from the Simons Foundation, the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, the US NIH/NINDS/NCCIH (R01AT012312, R01AT011439 and U19 NS128613) and the Novo Nordisk and Lundbeck Foundations, as well as the US Army Research Office (grant MURI W911NF1910280).

Author information

Authors and Affiliations

  1. Center for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark

    Virginia Plá & Maiken Nedergaard

  2. Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA

    Maiken Nedergaard

Authors
  1. Virginia Plá
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Maiken Nedergaard
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Virginia Plá.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Plá, V., Nedergaard, M. An unnoticed player overseeing CSF flux. Nat Cardiovasc Res 1, 1114–1115 (2022). https://doi.org/10.1038/s44161-022-00176-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s44161-022-00176-9

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing