The plasma of individuals with atherosclerosis contains cytokines that induce a pathogenic signaling cascade in immune cells. Saracatinib, a dual kinase inhibitor that targets the tyrosine kinases SRC and BCR-ABL, can prevent activation of this phospho-signaling pathway implicated in the pathogenesis of cardiovascular disease.
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Monaco, C., Dib, L. Modelling systemic risk factors in cardiovascular disease using single-cell biology. Nat Cardiovasc Res 2, 496–497 (2023). https://doi.org/10.1038/s44161-023-00285-z
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DOI: https://doi.org/10.1038/s44161-023-00285-z