We outline protein interaction networks for 13 ion channels isolated from mouse hearts and show that several protein components are shared between ion channel networks. Multi-omic data integration couples these findings to features of the human heart electrocardiogram and we evaluate the functional effect of ten network proteins on cardiac electrophysiology.
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This is a summary of: Maurya, S. et al. Outlining cardiac ion channel protein interactors and their signature in the human electrocardiogram. Nat. Cardiovas. Res. https://doi.org/10.1038/s44161-023-00294-y (2023).
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Protein networks for cardiac ion channels share protein components. Nat Cardiovasc Res 2, 611–612 (2023). https://doi.org/10.1038/s44161-023-00300-3
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DOI: https://doi.org/10.1038/s44161-023-00300-3
