The US Food and Drug Administration (FDA) has approved sotagliflozin with a broad heart-failure indication, even in the absence of trial data in patients without diabetes. No one knows what the benefits or risks of inhibiting SGLT1 in the heart might be.
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References
Borges-Júnior, F. A. et al. J. Am. Soc. Nephrol. 32, 1616–1629 (2021).
Packer, M. Circulation 146, 1383–1405 (2022).
Chan, L. K. Y., Wang, Y., Ng, E. K. W. & Leung, P. S. Diabetes Obes. Metab. 20, 709–717 (2018).
Turk, E., Zabel, B., Mundlos, S., Dyer, J. & Wright, E. M. Nature 350, 354–356 (1991).
SCORED Investigators. N. Engl. J. Med. 384, 129–139 (2021).
SOLOIST-WHF Trial Investigators. N. Engl. J. Med. 384, 117–128 (2021).
US FDA. INPEFA (sotagliflozin) tablets, for oral use. https://go.nature.com/3CVjPBw (2023).
van Raalte, D. H. et al. Diabetes Care 42, 1921–1929 (2019).
Sayour, A. A. et al. Cardiovasc Diabetol. 19, 159 (2020).
Ramratnam, M. et al. J. Am. Heart Assoc. 3, e000899 (2014).
Connelly, K. A., Zhang, Y., Desjardins, J. F., Thai, K. & Gilbert, R. E. Cardiovasc. Diabetol. 17, 99 (2018).
Ferté, L. et al. Am. J. Physiol. Heart Circ. Physiol. 320, H838–H853 (2021).
Takebayashi, K. & Inukai, T. J. Clin. Med. Res. 9, 745–753 (2017).
Posch, M. G. et al. Diabetes Care 45, 2118–2126 (2022).
Sudo, M. et al. Atherosclerosis 265, 283–291 (2017).
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In the past three years, M.P. has been a consultant to 89bio, Abbvie, Altimmune, Amgen, Ardelyx, AstraZeneca, Boehringer Ingelheim, Caladrius, Casana, CSL Behring, Cytokinetics, Imara, Lilly, Moderna, Novartis, Pharmacosmos, Reata, Regeneron, Relypsa and Salamandra.
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Packer, M. Dual SGLT1 and SGLT2 inhibitor sotagliflozin achieves FDA approval: landmark or landmine?. Nat Cardiovasc Res 2, 705–707 (2023). https://doi.org/10.1038/s44161-023-00306-x
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DOI: https://doi.org/10.1038/s44161-023-00306-x