The potential of tissue engineering to deliver clinical advances hinges on a connected ecosystem that includes academics, funding agencies, entrepreneurs, investors, the pharmaceutical industry and regulatory bodies. Open dialog on goals and risks across these stakeholders is key to implementing bioengineered tissue models in drug development and tissue therapies.
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The authors acknowledge all participants of the Wellcome Leap HOPE-meets-Industry event (7 December 2022) for the discussion on catalyzing bioengineering innovations.
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All authors contributed to researching data, discussing content and writing the manuscript. A.M. and K.A.H. reviewed and edited the manuscript for submission and publication.
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Related links
Advanced Regenerative Manufacturing Institute: https://www.armiusa.org/
Advanced Research and Invention Agency (Aria): https://www.aria.org.uk/
Advanced Research Projects Agency for Health (ARPA-H): https://arpa-h.gov/
American Society for Testing and Materials: https://www.astm.org/
Defense Advanced Research Projects Agency (DARPA): https://www.darpa.mil/
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Emergency Use Authorization: https://www.fda.gov/emergency-preparedness-and-response/mcm-legal-regulatory-and-policy-framework/emergency-use-authorization
European Organ-on-Chip Society: https://euroocs.eu/
FDA Alternative Methods working group: https://www.fda.gov/science-research/about-science-research-fda/advancing-alternative-methods-fda
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Federal Agency for Disruptive Innovations (SPRIN-D): https://www.sprind.org/en/
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IQ Microphysiological Systems Affiliate: https://www.iqmps.org/
International Microphysiological System Society: https://impss.org/
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National Centre for Advancing Translational Sciences: https://ncats.nih.gov/
Partnership between Semma Therapeutics and the Juvenile Diabetes Research Foundation: https://t1dfund.org/news/semma-therapeutics-receives-investment-from-jdrf-t1d-fund/
Right to Try Act: https://www.fda.gov/patients/learn-about-expanded-access-and-other-treatment-options/right-try
Tissue Chip for Drug Screening program: https://ncats.nih.gov/tissuechip
Tissue chip testing centers: https://ncats.nih.gov/tissuechip/projects/centers
Wellcome Leap: https://wellcomeleap.org/
Wellcome Leap HOPE Program: https://wellcomeleap.org/hope/
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Moisan, A., Kolesky, D., Miller, J. et al. Translation of tissue-engineering innovations requires a connected ecosystem. Nat Rev Bioeng 1, 879–881 (2023). https://doi.org/10.1038/s44222-023-00111-y
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DOI: https://doi.org/10.1038/s44222-023-00111-y