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In the recent Nature, Wang et al. and Zhong et al. present the cryo-EM structures of Gasdermin B (GSDMB) pore and strucures of GSDMB in complex with a Shigella effector, IpaH7.8. The structures shed light on the structural mechanisms that govern GSDMB-mediated pyroptosis, a process that is regulated by pathogenic bacteria and alternative splicing.
BAX and BAK are generally considered as fully interchangeable for mitochondrial permeabilization and consequent apoptotic cell death. Garcia-Saez and colleagues have recently documented striking kinetic differences that influence BAX and BAK oligomerization at the mitochondrial surface. These data have important implications for inflammatory responses driven by mitochondrial DNA.