Cancer Gene Therapy - AOP

Oncolytic adenovirus expressing interleukin-18 induces significant antitumor effects against melanoma in mice through inhibition of angiogenesis

J-N Zheng — 2009-06-05

Oncolytic adenovirus expressing interleukin-18 induces significant antitumor effects against melanoma in mice through inhibition of angiogenesis

Cancer Gene Therapy advance online publication, June 5, 2009. doi:10.1038/cgt.2009.38

Authors: J-N Zheng, D-S Pei, L-J Mao, X-Y Liu, F-H Sun, B-F Zhang, Y-Q Liu, J-J Liu, W Li & D Han

Enhancement of antitumor activity of gammaretrovirus carrying IL-12 gene through genetic modification of envelope targeting HER2 receptor: a promising strategy for bladder cancer therapy

Y-S Tsai — 2009-06-19

Enhancement of antitumor activity of gammaretrovirus carrying IL-12 gene through genetic modification of envelope targeting HER2 receptor: a promising strategy for bladder cancer therapy

Cancer Gene Therapy advance online publication, June 19, 2009. doi:10.1038/cgt.2009.41

Authors: Y-S Tsai, A-L Shiau, Y-F Chen, H-T Tsai, T-S Tzai & C-L Wu

Mutant mouse p53 transgene elevates the chemical induction of tumors that respond to gene silencing with siRNA

H Tanooka — 2009-06-26

Mutant mouse p53 transgene elevates the chemical induction of tumors that respond to gene silencing with siRNA

Cancer Gene Therapy advance online publication, June 26, 2009. doi:10.1038/cgt.2009.43

Authors: H Tanooka, K Tatsumi, H Tsuji, Y Noda, T Katsube, H Ishii, A Ootsuyama, F Takeshita & T Ochiya

Intraperitoneal administration of telomerase-specific oncolytic adenovirus sensitizes ovarian cancer cells to cisplatin and affects survival in a xenograft model with peritoneal dissemination

M Takakura — 2009-07-07

Intraperitoneal administration of telomerase-specific oncolytic adenovirus sensitizes ovarian cancer cells to cisplatin and affects survival in a xenograft model with peritoneal dissemination

Cancer Gene Therapy advance online publication, August 7, 2009. doi:10.1038/cgt.2009.44

Authors: M Takakura, M Nakamura, S Kyo, M Hashimoto, N Mori, T Ikoma, Y Mizumoto, T Fujiwara, Y Urata & M Inoue

Antitumoral efficacy of DNA nanoparticles in murine models of lung cancer and pulmonary metastasis

M Rodrigo-Garzón — 2009-07-03

Antitumoral efficacy of DNA nanoparticles in murine models of lung cancer and pulmonary metastasis

Cancer Gene Therapy advance online publication, July 3, 2009. doi:10.1038/cgt.2009.45

Authors: M Rodrigo-Garzón, P Berraondo, L Ochoa, J J Zulueta & G González-Aseguinolaza

Activated Ras signaling significantly enhances reovirus replication and spread

M Shmulevitz — 2009-07-10

Activated Ras signaling significantly enhances reovirus replication and spread

Cancer Gene Therapy advance online publication, July 10, 2009. doi:10.1038/cgt.2009.46

Authors: M Shmulevitz, P Marcato & P W K Lee

Suppression of ovarian cancer growth via systemic administration with liposome-encapsulated adenovirus-encoding endostatin

L Yang — 2009-07-17

Suppression of ovarian cancer growth via systemic administration with liposome-encapsulated adenovirus-encoding endostatin

Cancer Gene Therapy advance online publication, July 17, 2009. doi:10.1038/cgt.2009.47

Authors: L Yang, L Wang, X-q Su, L Wang, X-c Chen, D Li, S-t Luo, H-s Shi, L-j Chen & Y-s Wang

Heat-induced transcription of diphtheria toxin A or its variants, CRM176 and CRM197: implications for pancreatic cancer gene therapy

P Fogar — 2009-07-17

Heat-induced transcription of diphtheria toxin A or its variants, CRM176 and CRM197: implications for pancreatic cancer gene therapy

Cancer Gene Therapy advance online publication, July 17, 2009. doi:10.1038/cgt.2009.48

Authors: P Fogar, F Navaglia, D Basso, C-F Zambon, L Moserle, S Indraccolo, A Stranges, E Greco, E Fadi, A Padoan, G Pantano, M C Sanzari, S Pedrazzoli, C Montecucco & M Plebani

Downregulation of the coxsackie and adenovirus receptor in cancer cells by hypoxia depends on HIF-1α

K Küster — 2009-07-10

Downregulation of the coxsackie and adenovirus receptor in cancer cells by hypoxia depends on HIF-1α

Cancer Gene Therapy advance online publication, July 10, 2009. doi:10.1038/cgt.2009.49

Authors: K Küster, A Koschel, N Rohwer, A Fischer, B Wiedenmann & M Anders

Oncolytic and immunostimulatory efficacy of a targeted oncolytic poxvirus expressing human GM-CSF following intravenous administration in a rabbit tumor model

J-H Lee — 2009-07-24

Oncolytic and immunostimulatory efficacy of a targeted oncolytic poxvirus expressing human GM-CSF following intravenous administration in a rabbit tumor model

Cancer Gene Therapy advance online publication, July 24, 2009. doi:10.1038/cgt.2009.50

Authors: J-H Lee, M-S Roh, Y-K Lee, M-K Kim, J-Y Han, B-H Park, P Trown, D H Kirn & T-H Hwang

Enhancement of reporter gene detection sensitivity by insertion of specific mini-peptide-coding sequences

J Cutrera — 2009-07-28

Enhancement of reporter gene detection sensitivity by insertion of specific mini-peptide-coding sequences

Cancer Gene Therapy advance online publication, August 28, 2009. doi:10.1038/cgt.2009.54

Authors: J Cutrera, D Dibra, X Xia & S Li

Adenovirus-mediated transfer of siRNA against survivin enhances the radiosensitivity of human non-small cell lung cancer cells

C-T Yang — 2009-07-04

Adenovirus-mediated transfer of siRNA against survivin enhances the radiosensitivity of human non-small cell lung cancer cells

Cancer Gene Therapy advance online publication, September 4, 2009. doi:10.1038/cgt.2009.55

Authors: C-T Yang, J-M Li, H-H Weng, Y-C Li, H-C Chen & M-F Chen

Viral vector-induced expression of bone morphogenetic protein 2 produces inhibition of tumor growth and bone differentiation of stem cells

S Fong — 2009-10-16

Viral vector-induced expression of bone morphogenetic protein 2 produces inhibition of tumor growth and bone differentiation of stem cells

Cancer Gene Therapy advance online publication, October 16, 2009. doi:10.1038/cgt.2009.56

Authors: S Fong, M-K Chan, A Fong, W J Bowers & K J Kelly

Inhibition of autophagy induced by overexpression of mda-7/interleukin-24 strongly augments the antileukemia activity in vitro and in vivo

C Yang — 2009-07-04

Inhibition of autophagy induced by overexpression of mda-7/interleukin-24 strongly augments the antileukemia activity in vitro and in vivo

Cancer Gene Therapy advance online publication, September 4, 2009. doi:10.1038/cgt.2009.57

Authors: C Yang, Y Tong, W Ni, J Liu, W Xu, L Li, X Liu, H Meng & W Qian

An enteric pathogen Salmonella enterica serovar Typhimurium suppresses tumor growth by downregulating CD44high and CD4T regulatory (Treg) cell expression in mice: the critical role of lipopolysaccharide and Braun lipoprotein in modulating tumor growth

T Liu — 2009-07-28

An enteric pathogen Salmonella enterica serovar Typhimurium suppresses tumor growth by downregulating CD44high and CD4T regulatory (Treg) cell expression in mice: the critical role of lipopolysaccharide and Braun lipoprotein in modulating tumor growth

Cancer Gene Therapy advance online publication, August 28, 2009. doi:10.1038/cgt.2009.58

Authors: T Liu & A K Chopra

Inhibition of tumor growth and induction of apoptosis in prostate cancer cell lines by overexpression of tissue inhibitor of matrix metalloproteinase-3

L Zhang — 2009-10-02

Inhibition of tumor growth and induction of apoptosis in prostate cancer cell lines by overexpression of tissue inhibitor of matrix metalloproteinase-3

Cancer Gene Therapy advance online publication, October 2, 2009. doi:10.1038/cgt.2009.59

Authors: L Zhang, L Zhao, D Zhao, G Lin, B Guo, Y Li, Z Liang, X J Zhao & X Fang

Fusion enzymes containing HSV-1 thymidine kinase mutants and guanylate kinase enhance prodrug sensitivity in vitro and in vivo

A Ardiani — 2009-07-18

Fusion enzymes containing HSV-1 thymidine kinase mutants and guanylate kinase enhance prodrug sensitivity in vitro and in vivo

Cancer Gene Therapy advance online publication, September 18, 2009. doi:10.1038/cgt.2009.60

Authors: A Ardiani, M Sanchez-Bonilla & M E Black

Expression of chimeric antigen receptors in natural killer cells with a regulatory-compliant non-viral method

L Li — 2009-07-11

Expression of chimeric antigen receptors in natural killer cells with a regulatory-compliant non-viral method

Cancer Gene Therapy advance online publication, September 11, 2009. doi:10.1038/cgt.2009.61

Authors: L Li, L N Liu, S Feller, C Allen, R Shivakumar, J Fratantoni, L A Wolfraim, H Fujisaki, D Campana, N Chopas, S Dzekunov & M Peshwa

Antitumor activity of Ad-IU2, a prostate-specific replication-competent adenovirus encoding the apoptosis inducer, TRAIL

J A Jiménez — 2009-10-02

Antitumor activity of Ad-IU2, a prostate-specific replication-competent adenovirus encoding the apoptosis inducer, TRAIL

Cancer Gene Therapy advance online publication, October 2, 2009. doi:10.1038/cgt.2009.62

Authors: J A Jiménez, X Li, Y-P Zhang, K H Bae, Y Mohammadi, P Pandya, C Kao & T A Gardner

Improved nonviral cancer suicide gene therapy using survivin promoter-driven mutant Bax

H Garg — 2009-10-09

Improved nonviral cancer suicide gene therapy using survivin promoter-driven mutant Bax

Cancer Gene Therapy advance online publication, October 9, 2009. doi:10.1038/cgt.2009.63

Authors: H Garg, R Salcedo, G Trinchieri & R Blumenthal

The anti-glioma effect of suicide gene therapy using BMSC expressing HSV/TK combined with overexpression of Cx43 in glioma cells

Q Huang — 2009-10-23

The anti-glioma effect of suicide gene therapy using BMSC expressing HSV/TK combined with overexpression of Cx43 in glioma cells

Cancer Gene Therapy advance online publication, October 23, 2009. doi:10.1038/cgt.2009.64

Authors: Q Huang, X-Z Liu, C-S Kang, G-X Wang, Y Zhong & P-Y Pu

An HDAC inhibitor enhances the antitumor activity of a CMV promoter-driven DNA vaccine

M-D Lai — 2009-10-23

An HDAC inhibitor enhances the antitumor activity of a CMV promoter-driven DNA vaccine

Cancer Gene Therapy advance online publication, October 23, 2009. doi:10.1038/cgt.2009.65

Authors: M-D Lai, C-S Chen, C-R Yang, S-Y Yuan, J-J Tsai,, C-F Tu, C-C Wang, M-C Yen & C-C Lin

Silencing of HIF-1α suppresses tumorigenicity of renal cell carcinoma through induction of apoptosis

K Xu — 2009-10-09

Silencing of HIF-1α suppresses tumorigenicity of renal cell carcinoma through induction of apoptosis

Cancer Gene Therapy advance online publication, October 9, 2009. doi:10.1038/cgt.2009.66

Authors: K Xu, Q Ding, Z Fang, J Zheng, P Gao, Y Lu & Y Zhang

Reduction of nontarget infection and systemic toxicity by targeted delivery of conditionally replicating viruses transported in mesenchymal stem cells

J L Dembinski — 2009-10-30

Reduction of nontarget infection and systemic toxicity by targeted delivery of conditionally replicating viruses transported in mesenchymal stem cells

Cancer Gene Therapy advance online publication, October 30, 2009. doi:10.1038/cgt.2009.67

Authors: J L Dembinski, E L Spaeth, J Fueyo, C Gomez-Manzano, M Studeny, M Andreeff & F C Marini

Survivin knockdown by short hairpin RNA abrogates the growth of human hepatocellular carcinoma xenografts in nude mice

R Zhang — 2009-10-30

Survivin knockdown by short hairpin RNA abrogates the growth of human hepatocellular carcinoma xenografts in nude mice

Cancer Gene Therapy advance online publication, October 30, 2009. doi:10.1038/cgt.2009.68

Authors: R Zhang, L Ma, M Zheng, J Ren, T Wang, Y Meng, J Zhao, L Jia, L Yao, H Han, K Li & A Yang

In vitro and in vivo delivery of novel anticancer fusion protein MULT1E/FasTI via adenoviral vectors

H S R Kotturi — 2009-10-09

In vitro and in vivo delivery of novel anticancer fusion protein MULT1E/FasTI via adenoviral vectors

Cancer Gene Therapy advance online publication, October 9, 2009. doi:10.1038/cgt.2009.69

Authors: H S R Kotturi, J Li, M Branham-O'Connor, X Yu, T E Wagner & Y Wei

Enhanced specific delivery and targeting of oncolytic Sindbis viral vectors by modulating vascular leakiness in tumor

J-C Tseng — 2009-10-02

Enhanced specific delivery and targeting of oncolytic Sindbis viral vectors by modulating vascular leakiness in tumor

Cancer Gene Therapy advance online publication, October 2, 2009. doi:10.1038/cgt.2009.70

Authors: J-C Tseng, T Granot, V DiGiacomo, B Levin & D Meruelo

Imaging and therapy of experimental schwannomas using HSV amplicon vector-encoding apoptotic protein under Schwann cell promoter

S Prabhakar — 2009-10-16

Imaging and therapy of experimental schwannomas using HSV amplicon vector-encoding apoptotic protein under Schwann cell promoter

Cancer Gene Therapy advance online publication, October 16, 2009. doi:10.1038/cgt.2009.71

Authors: S Prabhakar, G J Brenner, B Sung, S M Messerli, J Mao, M Sena-Esteves, A Stemmer-Rachamimov, B Tannous & X O Breakefield

A modified hTERT promoter-directed oncolytic adenovirus replication with concurrent inhibition of TGFβ signaling for breast cancer therapy

Z Hu — 2009-10-02

A modified hTERT promoter-directed oncolytic adenovirus replication with concurrent inhibition of TGFβ signaling for breast cancer therapy

Cancer Gene Therapy advance online publication, October 2, 2009. doi:10.1038/cgt.2009.72

Authors: Z Hu, J S Robbins, A Pister, M B Zafar, Z-W Zhang, J Gupta, K J Lee, K Neuman, C-O Yun, T Guise & P Seth

Identification of virus resistant tumor cell subpopulations in three-dimensional uveal melanoma cultures

K Valyi-Nagy — 200-11-06

Identification of virus resistant tumor cell subpopulations in three-dimensional uveal melanoma cultures

Cancer Gene Therapy advance online publication, November 6, 2009. doi:10.1038/cgt.2009.73

Authors: K Valyi-Nagy, S Dosa, S K Kovacs, S Bacsa, A Voros, D Shukla, R Folberg & T Valyi-Nagy

Fusogenic membrane glycoproteins induce syncytia formation and death in vitro and in vivo: a potential therapy agent for lung cancer

E-H Lin — 200-11-06

Fusogenic membrane glycoproteins induce syncytia formation and death in vitro and in vivo: a potential therapy agent for lung cancer

Cancer Gene Therapy advance online publication, November 6, 2009. doi:10.1038/cgt.2009.74

Authors: E-H Lin, C Salon, E Brambilla, D Lavillette, J Szecsi, F-L Cosset & J-L Coll

Intratumoral delivery of shRNA targeting cyclin D1 attenuates pancreatic cancer growth

S J Deharvengt — 2009-10-23

Intratumoral delivery of shRNA targeting cyclin D1 attenuates pancreatic cancer growth

Cancer Gene Therapy advance online publication, October 23, 2009. doi:10.1038/cgt.2009.75

Authors: S J Deharvengt, J R Gunn, S B Pickett & M Korc

Bovine herpesvirus type 1 as a novel oncolytic virus

R Rodrigues — 200-11-06

Bovine herpesvirus type 1 as a novel oncolytic virus

Cancer Gene Therapy advance online publication, November 6, 2009. doi:10.1038/cgt.2009.77

Authors: R Rodrigues, B Cuddington & K Mossman

Genetic immunotherapy of lung cancer using conditionally replicating adenovirus and adenovirus-interferon-β

M-Y Park — 200-11-06

Genetic immunotherapy of lung cancer using conditionally replicating adenovirus and adenovirus-interferon-β

Cancer Gene Therapy advance online publication, November 6, 2009. doi:10.1038/cgt.2009.78

Authors: M-Y Park, D R Kim, H W Jung, H-I Yoon, J H Lee & C-T Lee

Using lentiviral vectors for efficient pancreatic cancer gene therapy

E Ravet — 200-11-13

Using lentiviral vectors for efficient pancreatic cancer gene therapy

Cancer Gene Therapy advance online publication, November 13, 2009. doi:10.1038/cgt.2009.79

Authors: E Ravet, H Lulka, F Gross, L Casteilla, L Buscail & P Cordelier

Human neural stem cells transduced with IFN-β and cytosine deaminase genes intensify bystander effect in experimental glioma

S Ito — 200-11-06

Human neural stem cells transduced with IFN-β and cytosine deaminase genes intensify bystander effect in experimental glioma

Cancer Gene Therapy advance online publication, November 6, 2009. doi:10.1038/cgt.2009.80

Authors: S Ito, A Natsume, S Shimato, M Ohno, T Kato, P Chansakul, T Wakabayashi & S U Kim