Possible pharmacological perspectives of aldosterone breakthrough. 11βHSD, 11 β-hydroxysteroid dehydrogenase; ACE-i, angiotensin converting enzyme inhibitor; AGT, angiotensinogen; Aldo, aldosterone; Ang I, angiotensin I; Ang II, angiotensin II; ARB, angiotensin II receptor blocker; AT1R, angiotensin II type 1 receptor; CYP11B2, cytochrome P450 family 11 subfamily B member 2; K+, potassium ion; MR, mineralocorticoid receptor; RAAS, renin-angiotensin aldosterone system; R-i, renin inhibitor.
