The EMBO Journal - Issue - nature.com science feeds

Enlightening the impact of immunogenic cell death in photodynamic cancer therapy

Lorenzo Galluzzi — 2012-01-17

Enlightening the impact of immunogenic cell death in photodynamic cancer therapy

The EMBO Journal 31, 1055 (2012). doi:10.1038/emboj.2012.2

Authors: Lorenzo Galluzzi, Oliver Kepp & Guido Kroemer

EMBO J315, 1062–1079 (2012); published online 17 January 2012In this issue of The EMBO Journal, Garg et al (2012) delineate a signalling pathway that leads to calreticulin (CRT) exposure and ATP release by cancer cells that succumb to photodynamic therapy (PTD), thereby providing fresh insights into the molecular regulation of immunogenic cell death (ICD).

B-type lamins and their elusive roles in metazoan cell proliferation and senescence

Christopher J Hutchison — 2012-02-17

B-type lamins and their elusive roles in metazoan cell proliferation and senescence

The EMBO Journal 31, 1058 (2012). doi:10.1038/emboj.2012.39

Author: Christopher J Hutchison

EMBO J315, 1080–1094 (2012); published online 13 January 2012Have you seen the recent papers that question the traditional role of B-type lamins in DNA replication and transcription, but highlight an entirely novel yet fundamental role for lamin B1 (LB1) in cell proliferation and cellular senescence?

To be or not to be a stem cell: dissection of cellular and molecular components of haematopoietic stem cell niches

John M Perry — 2012-02-10

To be or not to be a stem cell: dissection of cellular and molecular components of haematopoietic stem cell niches

The EMBO Journal 31, 1060 (2012). doi:10.1038/emboj.2012.29

Authors: John M Perry & Linheng Li

Nature4817382, 457–462 (2012); published online 25 January 2012Recent studies have identified multiple cell types that regulate haematopoietic stem cells (HSCs); however, proof that a specific cell type produces a specific factor important for HSC function and maintenance is largely lacking. Ding et al (2012) reported recently that conditional deletion of stem cell factor (SCF) in Leptin receptor (Lepr) expressing perivascular cells or endothelial and haematopoietic cells resulted in significant reductions in number but less profound reduction in function of HSCs. Although the long-term fate of HSCs in these models is largely unexplored and an underlying mechanism for reduction in HSCs not yet reported, these findings further implicate the vascular niche in the functional maintenance of HSCs in vivo and also raise intriguing questions for future studies in this field.

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

Abhishek D Garg — 2012-01-17

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

The EMBO Journal 31, 1062 (2012). doi:10.1038/emboj.2011.497

Authors: Abhishek D Garg, Dmitri V Krysko, Tom Verfaillie, Agnieszka Kaczmarek, Gabriela B Ferreira, Thierry Marysael, Noemi Rubio, Malgorzata Firczuk, Chantal Mathieu, Anton J M Roebroek, Wim Annaert, Jakub Golab, Peter de Witte, Peter Vandenabeele & Patrizia Agostinis

Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation

Aurelia Barascu — 2012-01-13

Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation

The EMBO Journal 31, 1080 (2012). doi:10.1038/emboj.2011.492

Authors: Aurelia Barascu, Catherine Le Chalony, Gaëlle Pennarun, Diane Genet, Naima Imam, Bernard Lopez & Pascale Bertrand

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

Carmine Settembre — 2012-02-17

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

The EMBO Journal 31, 1095 (2012). doi:10.1038/emboj.2012.32

Authors: Carmine Settembre, Roberto Zoncu, Diego L Medina, Francesco Vetrini, Serkan Erdin, SerpilUckac Erdin, Tuong Huynh, Mathieu Ferron, Gerard Karsenty, Michel C Vellard, Valeria Facchinetti, David M Sabatini & Andrea Ballabio

A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling

Masamichi Imajo — 2012-01-10

A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling

The EMBO Journal 31, 1109 (2012). doi:10.1038/emboj.2011.487

Authors: Masamichi Imajo, Koichi Miyatake, Akira Iimura, Atsumu Miyamoto & Eisuke Nishida

STIM1 is required for attenuation of PMCA-mediated Ca2+ clearance during T-cell activation

Michael F Ritchie — 2012-01-13

STIM1 is required for attenuation of PMCA-mediated Ca2+ clearance during T-cell activation

The EMBO Journal 31, 1123 (2012). doi:10.1038/emboj.2011.495

Authors: Michael F Ritchie, Elsie Samakai & Jonathan Soboloff

Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis

Veronique Nogueira — 2012-02-03

Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis

The EMBO Journal 31, 1134 (2012). doi:10.1038/emboj.2011.478

Authors: Veronique Nogueira, Deepa Sundararajan, Jennifer M Kwan, Xiao-ding Peng, Neha Sarvepalli, Nahum Sonenberg & Nissim Hay

Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice

Hoogeun Song — 2012-01-06

Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice

The EMBO Journal 31, 1147 (2012). doi:10.1038/emboj.2011.480

Authors: Hoogeun Song, Hyunsoo Kim, Kyunghee Lee, Da-Hye Lee, Tae-Shin Kim, Ji Yun Song, Dongjun Lee, Dongwook Choi, Chang-Yong Ko, Han-Sung Kim, Hong-In Shin, Juhyun Choi, Heedong Park, Chankyu Park, Daewon Jeong & Dae-Sik Lim

APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer

Rachel Brough — 2012-01-31

APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer

The EMBO Journal 31, 1160 (2012). doi:10.1038/emboj.2011.490

Authors: Rachel Brough, Ilirjana Bajrami, Radost Vatcheva, Rachael Natrajan, Jorge S Reis-Filho, Christopher J Lord & Alan Ashworth

ATR maintains select progenitors during nervous system development

Youngsoo Lee — 2012-01-20

ATR maintains select progenitors during nervous system development

The EMBO Journal 31, 1177 (2012). doi:10.1038/emboj.2011.493

Authors: Youngsoo Lee, Erin RP Shull, Pierre-Olivier Frappart, Sachin Katyal, Vanessa Enriquez-Rios, Jingfeng Zhao, Helen R Russell, Eric J Brown & Peter J McKinnon

RP58 controls neuron and astrocyte differentiation by downregulating the expression of Id1–4 genes in the developing cortex

Shinobu Hirai — 2012-01-10

RP58 controls neuron and astrocyte differentiation by downregulating the expression of Id1–4 genes in the developing cortex

The EMBO Journal 31, 1190 (2012). doi:10.1038/emboj.2011.486

Authors: Shinobu Hirai, Akiko Miwa, Chiaki Ohtaka-Maruyama, Masataka Kasai, Shigeo Okabe, Yutaka Hata & Haruo Okado

CaMKII binding to GluN2B is critical during memory consolidation

Amy R Halt — 2012-01-10

CaMKII binding to GluN2B is critical during memory consolidation

The EMBO Journal 31, 1203 (2012). doi:10.1038/emboj.2011.482

Authors: Amy R Halt, Robert F Dallapiazza, Yu Zhou, Ivar S Stein, Hai Qian, Scott Juntti, Sonja Wojcik, Nils Brose, Alcino J Silva & Johannes W Hell

Raising cytosolic Cl− in cerebellar granule cells affects their excitability and vestibulo-ocular learning

Patricia Seja — 2012-01-17

Raising cytosolic Cl− in cerebellar granule cells affects their excitability and vestibulo-ocular learning

The EMBO Journal 31, 1217 (2012). doi:10.1038/emboj.2011.488

Authors: Patricia Seja, Martijn Schonewille, Guillermo Spitzmaul, Aleksandra Badura, Ilse Klein, York Rudhard, William Wisden, Christian A Hübner, Chris I De Zeeuw & Thomas J Jentsch

Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism

Flavia Antonucci — 2012-01-13

Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism

The EMBO Journal 31, 1231 (2012). doi:10.1038/emboj.2011.489

Authors: Flavia Antonucci, Elena Turola, Loredana Riganti, Matteo Caleo, Martina Gabrielli, Cristiana Perrotta, Luisa Novellino, Emilio Clementi, Paola Giussani, Paola Viani, Michela Matteoli & Claudia Verderio

Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking

Todd J Cohen — 2011-12-23

Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking

The EMBO Journal 31, 1241 (2012). doi:10.1038/emboj.2011.471

Authors: Todd J Cohen, Andrew W Hwang, Travis Unger, John Q Trojanowski & Virginia M Y Lee

Genetic evidence of a redox-dependent systemic wound response via Hayan Protease-Phenoloxidase system in Drosophila

Hyuck-Jin Nam — 2012-01-06

Genetic evidence of a redox-dependent systemic wound response via Hayan Protease-Phenoloxidase system in Drosophila

The EMBO Journal 31, 1253 (2012). doi:10.1038/emboj.2011.476

Authors: Hyuck-Jin Nam, In-Hwan Jang, Hyejin You, Kyung-Ah Lee & Won-Jae Lee

A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX

Ryan E Henry — 2012-01-13

A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX

The EMBO Journal 31, 1266 (2012). doi:10.1038/emboj.2011.498

Authors: Ryan E Henry, Zdenek Andrysik, Ramiro París, Matthew D Galbraith & Joaquín M Espinosa

Rsk-mediated phosphorylation and 14-3-3ɛ binding of Apaf-1 suppresses cytochrome c-induced apoptosis

Jiyeon Kim — 2012-01-13

Rsk-mediated phosphorylation and 14-3-3ɛ binding of Apaf-1 suppresses cytochrome c-induced apoptosis

The EMBO Journal 31, 1279 (2012). doi:10.1038/emboj.2011.491

Authors: Jiyeon Kim, Amanda B Parrish, Manabu Kurokawa, Kenkyo Matsuura, Christopher D Freel, Joshua L Andersen, Carrie E Johnson & Sally Kornbluth

Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly

Hue-Tran Hornig-Do — 2012-01-17

Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly

The EMBO Journal 31, 1293 (2012). doi:10.1038/emboj.2011.477

Authors: Hue-Tran Hornig-Do, Takashi Tatsuta, Angela Buckermann, Maria Bust, Gittan Kollberg, Agnes Rötig, Martin Hellmich, Leo Nijtmans & Rudolf J Wiesner

Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin

Manjeet Mukherjee — 2012-01-17

Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin

The EMBO Journal 31, 1308 (2012). doi:10.1038/emboj.2011.496

Authors: Manjeet Mukherjee, Soah Yee Chow, Permeen Yusoff, J Seetharaman, Cherlyn Ng, Saravanan Sinniah, Xiao Woon Koh, Nur Farehan M Asgar, Dan Li, Daniel Yim, Rebecca A Jackson, Jingxi Yew, Jingru Qian, Audrey Iyu, Yoon Pin Lim, Xingding Zhou, Siu Kwan Sze, Graeme R Guy & J Sivaraman

Mechanism of RNA synthesis initiation by the vesicular stomatitis virus polymerase

Benjamin Morin — 2012-01-13

Mechanism of RNA synthesis initiation by the vesicular stomatitis virus polymeraseThe genome of most negative-strand RNA viruses is encased by the nucleoprotein N forming the N-RNA RNP and replicated by the L/P polymerase complex. The authors show for the first time that in vesicular stomatitis virus L protein can initiate de-novo synthesis of naked RNA independently of N or P, although P stimulates L initiation and processivity.