EMBO Reports 10, 1183 (2009). doi:10.1038/embor.2009.228

Author: Howy Jacobs

The renewed calls for an academic boycott of Israel (see the Opinion article by Steven Rose in this issue) raise the fundamental question of whether and how this sanction should be applied.Boycotts can be effective when the target is appropriate, when the case is

EMBO Reports 10, 1184 (2009). doi:10.1038/embor.2009.229

Author: Steven Rose

Many readers of this journal will, like me, have Israeli colleagues whose research we respect, with whom we have collaborated, and among whom we have friends. Yet, these relationships have been overshadowed by the human rights abuses inflicted against the Palestinians, Israel's flouting of UN

EMBO Reports 10, 1185 (2009). doi:10.1038/embor.2009.227

Author: Christophe Lavelle

The cover illustration of the August 2009 issue of EMBO reports, although aesthetically pleasing, is unfortunately erroneous and could come as a shock to researchers in the chromatin field. Canonical nucleosomes are indeed left-handed, such as the nucleosomes in the left ‘column’ of chromatin

EMBO Reports 10, 1186 (2009). doi:10.1038/embor.2009.235

Author: Mark Patterson

Howy Jacobs's light-hearted exploration of where the perverse incentives surrounding the quest for publication in high impact-factor journals might lead paints a gruesome picture. Of course, there is a serious message in his October editorial, and even now many would argue that our fixation with

EMBO Reports 10, 1187 (2009). doi:10.1038/embor.2009.230

Author: Jakub Kwieciński

Widespread opposition to GMOs might have deep-seated cultural causes

EMBO Reports 10, 1191 (2009). doi:10.1038/embor.2009.225

Author: Valentí Rull

Is a world without humans possible?

EMBO Reports 10, 1196 (2009). doi:10.1038/embor.2009.226

Author: Howard Wolinsky

International mobility is not restricted to young scientists

EMBO Reports 10, 1198 (2009). doi:10.1038/embor.2009.234

Author: Philip Hunter

Is human intelligence still evolving?

EMBO Reports 10, 1202 (2009). doi:10.1038/embor.2009.222

Authors: Ben C. Collins, Thomas Y. K. Lau, Darran P. O'Connor & Hubert Hondermarck

IntroductionThe first conference of the EMBO Cancer Proteomics series aimed to bring investigators from oncological backgrounds (both basic and clinical) into close contact with equivalent leaders in proteomics approaches, to establish a translational framework by which proteomics can advance our mechanistic understanding of cancer-related

EMBO Reports 10, 1206 (2009). doi:10.1038/embor.2009.224

Authors: Douglas M. Cyr & Daniel N. Hebert

See Glossary for abbreviations used in this article.IntroductionThe correct folding of proteins is essential for cellular homeostasis and the prevention of disease. During times of stress or changes in demand for newly synthesized proteins, signalling pathways cooperate with networks of protein-folding and

EMBO Reports 10, 1211 (2009). doi:10.1038/embor.2009.231

Authors: Thomas Boesen & Poul Nissen

Vacuolar H+-ATPases (V-ATPases) were discovered more than 30 years ago. They are related to the F-ATPases—that is, ATP synthases—but have been refined for proton pumping by the rotary ATPase activity and are responsible for the acidification of intracellular compartments. Acidification is crucial for

EMBO Reports 10, 1213 (2009). doi:10.1038/embor.2009.221

Authors: Emily Brookes & Ana Pombo

The regulation of gene expression programmes is essential for the generation of diverse cell types during development and for adaptation to environmental signals. RNA polymerase II (RNAPII) transcribes genetic information and coordinates the recruitment of accessory proteins that are responsible for the establishment of active

EMBO Reports 10, 1220 (2009). doi:10.1038/embor.2009.223

Authors: Alexander Ploss & Charles M. Rice

Hepatitis C virus (HCV) causes chronic liver disease and affects an estimated 3% of the world's population. Options for the prevention or therapy of HCV infection are limited; there is no vaccine and the nonspecific, interferon-based treatments now in use are frequently ineffective and have

EMBO Reports 10, 1228 (2009). doi:10.1038/embor.2009.202

Authors: Nobutaka Numoto, Yu Hasegawa, Kazuki Takeda & Kunio Miki

V-type ATPases (V-ATPases) are categorized as rotary ATP synthase/ATPase complexes. The V-ATPases are distinct from F-ATPases in terms of their rotation scheme, architecture and subunit composition. However, there is no detailed structural information on V-ATPases despite the abundant biochemical and biophysical research. Here, we report

EMBO Reports 10, 1235 (2009). doi:10.1038/embor.2009.218

Authors: Junji Otani, Toshiyuki Nankumo, Kyohei Arita, Susumu Inamoto, Mariko Ariyoshi & Masahiro Shirakawa

DNMT3 proteins are de novo DNA methyltransferases that are responsible for the establishment of DNA methylation patterns in mammalian genomes. Here, we have determined the crystal structures of the ATRX–DNMT3–DNMT3L (ADD) domain of DNMT3A in an unliganded form and in a complex with the

EMBO Reports 10, 1242 (2009). doi:10.1038/embor.2009.210

Authors: Acacia Lamb, Xiao-Dong Yang, Ying-Hung N Tsang, Jiang-Dong Li, Hideaki Higashi, Masanori Hatakeyama, Richard M Peek, Steven R Blanke & Lin-Feng Chen

Helicobacter pylori-initiated chronic gastritis is characterized by the cag pathogenicity island-dependent upregulation of proinflammatory cytokines, which is largely mediated by the transcription factor nuclear factor (NF)-κB. However, the cag pathogenicity island-encoded proteins and cellular signalling molecules that are involved in H. pylori

EMBO Reports 10, 1250 (2009). doi:10.1038/embor.2009.192

Authors: Roland Hjerpe, Fabienne Aillet, Fernando Lopitz-Otsoa, Valerie Lang, Patrick England & Manuel S Rodriguez

Post-translational modification with ubiquitin is one of the most important mechanisms in the regulation of protein stability and function. However, the high reversibility of this modification is the main obstacle for the isolation and characterization of ubiquitylated proteins. To overcome this problem, we have developed

EMBO Reports 10, 1259 (2009). doi:10.1038/embor.2009.201

Authors: Daniela Meilinger, Karin Fellinger, Sebastian Bultmann, Ulrich Rothbauer, Ian Marc Bonapace, Wolfgang E F Klinkert, Fabio Spada & Heinrich Leonhardt

Recent studies have indicated that nuclear protein of 95 kDa (Np95) is essential for maintaining genomic methylation by recruiting DNA methyltransferase (Dnmt) 1 to hemi-methylated sites. Here, we show that Np95 interacts more strongly with regulatory domains of the de novo methyltransferases Dnmt3a and

EMBO Reports 10, 1265 (2009). doi:10.1038/embor.2009.200

Authors: Kazushige Kuroha, Tsuyako Tatematsu & Toshifumi Inada

Aberrant messenger RNAs containing a premature termination codon (PTC) are eliminated by the nonsense-mediated mRNA decay (NMD) pathway. Here, we show that a crucial NMD factor, up frameshift 1 protein (Upf1), is required for rapid proteasome-mediated degradation of an aberrant protein (PTC product) derived from

EMBO Reports 10, 1272 (2009). doi:10.1038/embor.2009.197

Authors: Jingxin Wang, Naduparambil K Jacob, Katherine J Ladner, Amer Beg, James D Perko, Stephan M Tanner, Sandya Liyanarachchi, Richard Fishel & Denis C Guttridge

Nuclear factor (NF)-κB is a positive regulator of tumour development and progression, but how it functions in normal cells leading to oncogenesis is not clear. As cellular senescence has proven to be an intrinsic tumour suppressor mechanism that cells must overcome to establish deregulated growth,

EMBO Reports 10, 1279 (2009). doi:10.1038/embor.2009.220

Author: Sara Salinas & Nir Gov

EMBO reports (2009) 10: 953–957. doi:10.1038/embor.2009.195We regret that the above Meeting Report, printed in the September issue of the journal, contained an error in the discussion of N. Kam's (Rehovot, Israel) presentation concerning neuron response to