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Identification of the immunodominant cytotoxic T-cell epitope of human -1 antitrypsin

E Breous — 2009-07-20

Identification of the immunodominant cytotoxic T-cell epitope of human -1 antitrypsin

Gene Therapy advance online publication, August 20, 2009. doi:10.1038/gt.2009.100

Authors: E Breous, S Somanathan & J M Wilson

Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints

L H Vandenberghe — 2009-07-03

Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints

Gene Therapy advance online publication, September 3, 2009. doi:10.1038/gt.2009.101

Authors: L H Vandenberghe, E Breous, H-J Nam, G Gao, R Xiao, A Sandhu, J Johnston, Z Debyser, M Agbandje-McKenna & J M Wilson

A modified E2F-1 promoter improves the efficacy to toxicity ratio of oncolytic adenoviruses

J J Rojas — 2009-07-27

A modified E2F-1 promoter improves the efficacy to toxicity ratio of oncolytic adenoviruses

Gene Therapy advance online publication, August 27, 2009. doi:10.1038/gt.2009.103

Authors: J J Rojas, M Cascallo, S Guedan, A Gros, J Martinez-Quintanilla, A Hemminki & R Alemany

Gene therapy with a promoter targeting both rods and cones rescues retinal degeneration caused by AIPL1 mutations

X Sun — 2009-07-27

Gene therapy with a promoter targeting both rods and cones rescues retinal degeneration caused by AIPL1 mutations

Gene Therapy advance online publication, August 27, 2009. doi:10.1038/gt.2009.104

Authors: X Sun, B Pawlyk, X Xu, X Liu, O V Bulgakov, M Adamian, M A Sandberg, S C Khani, M-H Tan, A J Smith, R R Ali & T Li

A versatile nonviral vector system for tetracycline-dependent one-step conditional induction of transgene expression

K Inoue — 2009-07-17

A versatile nonviral vector system for tetracycline-dependent one-step conditional induction of transgene expression

Gene Therapy advance online publication, September 17, 2009. doi:10.1038/gt.2009.105

Authors: K Inoue, T Sone, C Oneyama, F Nishiumi, H Kishine, Y Sasaki, T Andoh, M Okada, J D Chesnut & F Imamoto

Delivering multiple gene products in the brain from a single adeno-associated virus vector

S B Foti — 2009-07-03

Delivering multiple gene products in the brain from a single adeno-associated virus vector

Gene Therapy advance online publication, September 3, 2009. doi:10.1038/gt.2009.106

Authors: S B Foti, R J Samulski & T J McCown

Suicide gene therapy on spontaneous canine melanoma: correlations between in vivo tumors and their derived multicell spheroids in vitro

M L Gil-Cardeza — 2009-07-10

Suicide gene therapy on spontaneous canine melanoma: correlations between in vivo tumors and their derived multicell spheroids in vitro

Gene Therapy advance online publication, September 10, 2009. doi:10.1038/gt.2009.107

Authors: M L Gil-Cardeza, M S Villaverde, G L Fiszman, N A Altamirano, R A Cwirenbaum, G C Glikin & L M E Finocchiaro

Fatty acid–spermine conjugates as DNA carriers for nonviral in vivo gene delivery

J R Viola — 2009-07-03

Fatty acid–spermine conjugates as DNA carriers for nonviral in vivo gene delivery

Gene Therapy advance online publication, September 3, 2009. doi:10.1038/gt.2009.108

Authors: J R Viola, H Leijonmarck, O E Simonson, I I Oprea, R Frithiof, P Purhonen, P M D Moreno, K E Lundin, R Strömberg & C I E Smith

Autoregulatory lentiviral vectors allow multiple cycles of doxycycline-inducible gene expression in human hematopoietic cells in vivo

M Centlivre — 2009-07-03

Autoregulatory lentiviral vectors allow multiple cycles of doxycycline-inducible gene expression in human hematopoietic cells in vivo

Gene Therapy advance online publication, September 3, 2009. doi:10.1038/gt.2009.109

Authors: M Centlivre, X Zhou, S M Pouw, K Weijer, W Kleibeuker, A T Das, B Blom, J Seppen, B Berkhout & N Legrand

Neuroprotection using gene therapy to induce vascular endothelial growth factor-A expression

S A Sakowski — 2009-07-03

Neuroprotection using gene therapy to induce vascular endothelial growth factor-A expression

Gene Therapy advance online publication, September 3, 2009. doi:10.1038/gt.2009.111

Authors: S A Sakowski, S B Heavener, J S Lunn, K Fung, S S Oh, S K Spratt, N D Hogikyan & E L Feldman

Plasmids encoding the mucosal chemokines CCL27 and CCL28 are effective adjuvants in eliciting antigen-specific immunity in vivo

M A Kutzler — 2009-10-22

Plasmids encoding the mucosal chemokines CCL27 and CCL28 are effective adjuvants in eliciting antigen-specific immunity in vivo

Gene Therapy advance online publication, October 22, 2009. doi:10.1038/gt.2009.112

Authors: M A Kutzler, K A Kraynyak, S J Nagle, R M Parkinson, D Zharikova, M Chattergoon, H Maguire, K Muthumani, K Ugen & D B Weiner

AAV9-mediated erythropoietin gene delivery into the brain protects nigral dopaminergic neurons in a rat model of Parkinson's disease

Y-Q Xue — 2009-07-03

AAV9-mediated erythropoietin gene delivery into the brain protects nigral dopaminergic neurons in a rat model of Parkinson's disease

Gene Therapy advance online publication, September 3, 2009. doi:10.1038/gt.2009.113

Authors: Y-Q Xue, B-F Ma, L-R Zhao, J B Tatom, B Li, L-X Jiang, R L Klein & W-M Duan

The developmental stage determines the distribution and duration of gene expression after early intra-amniotic gene transfer using lentiviral vectors

M Endo — 2009-07-03

The developmental stage determines the distribution and duration of gene expression after early intra-amniotic gene transfer using lentiviral vectors

Gene Therapy advance online publication, September 3, 2009. doi:10.1038/gt.2009.115

Authors: M Endo, T Henriques-Coelho, P W Zoltick, D H Stitelman, W H Peranteau, A Radu & A W Flake

Therapeutic potential of genetically modified adult stem cells for osteopenia

S Kumar — 2009-07-10

Therapeutic potential of genetically modified adult stem cells for osteopenia

Gene Therapy advance online publication, September 10, 2009. doi:10.1038/gt.2009.116

Authors: S Kumar, T R Nagy & S Ponnazhagan

PDGF-B gene therapy accelerates bone engineering and oral implant osseointegration

P-C Chang — 2009-07-10

PDGF-B gene therapy accelerates bone engineering and oral implant osseointegration

Gene Therapy advance online publication, September 10, 2009. doi:10.1038/gt.2009.117

Authors: P-C Chang, Y-J Seol, J A Cirelli, G Pellegrini, Q Jin, L M Franco, S A Goldstein, L A Chandler, B Sosnowski & W V Giannobile

Foamy combinatorial anti-HIV vectors with MGMTP140K potently inhibit HIV-1 and SHIV replication and mediate selection in vivo

H-P Kiem — 2009-07-10

Foamy combinatorial anti-HIV vectors with MGMTP140K potently inhibit HIV-1 and SHIV replication and mediate selection in vivo

Gene Therapy advance online publication, September 10, 2009. doi:10.1038/gt.2009.118

Authors: H-P Kiem, R A Wu, G Sun, D von Laer, J J Rossi & G D Trobridge

Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6

C Towne — 2009-07-03

Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6

Gene Therapy advance online publication, September 3, 2009. doi:10.1038/gt.2009.119

Authors: C Towne, B L Schneider, D Kieran, D E Redmond & P Aebischer

Dose-dependent restoration of dystrophin expression in cardiac muscle of dystrophic mice by systemically delivered morpholino

B Wu — 2009-07-17

Dose-dependent restoration of dystrophin expression in cardiac muscle of dystrophic mice by systemically delivered morpholino

Gene Therapy advance online publication, September 17, 2009. doi:10.1038/gt.2009.120

Authors: B Wu, P Lu, E Benrashid, S Malik, J Ashar, T J Doran & Q L Lu

A vaccine that delivers rather than induces antibodies

N L Letvin — 2009-07-17

A vaccine that delivers rather than induces antibodies

Gene Therapy advance online publication, September 17, 2009. doi:10.1038/gt.2009.121

Author: N L Letvin

Partial protection against SIV challenge by vaccination of adenovirus and MVA vectors in rhesus monkeys

H-B Wang — 2009-07-17

Partial protection against SIV challenge by vaccination of adenovirus and MVA vectors in rhesus monkeys

Gene Therapy advance online publication, September 17, 2009. doi:10.1038/gt.2009.122

Authors: H-B Wang, A Kondo, A Yoshida, S Yoshizaki, S Abe, L-L Bao, N Mizuki, M Ichino, D Klinman, K Okuda & M Shimada

AAV5-mediated gene transfer to the parotid glands of non-human primates

A Voutetakis — 2009-07-17

AAV5-mediated gene transfer to the parotid glands of non-human primates

Gene Therapy advance online publication, September 17, 2009. doi:10.1038/gt.2009.123

Authors: A Voutetakis, C Zheng, A P Cotrim, F Mineshiba, S Afione, N Roescher, W D Swaim, M Metzger, M A Eckhaus, R E Donahue, C E Dunbar, J A Chiorini & B J Baum

High efficiency non-viral transfection of retinal and iris pigment epithelial cells with pigment epithelium-derived factor

G Thumann — 2009-07-10

High efficiency non-viral transfection of retinal and iris pigment epithelial cells with pigment epithelium-derived factor

Gene Therapy advance online publication, September 10, 2009. doi:10.1038/gt.2009.124

Authors: G Thumann, M Stöcker, C Maltusch, A K Salz, S Barth, P Walter & S Johnen

The impact of antigen expression in antigen-presenting cells on humoral immune responses against the transgene product

Y Feng — 2009-07-17

The impact of antigen expression in antigen-presenting cells on humoral immune responses against the transgene product

Gene Therapy advance online publication, September 17, 2009. doi:10.1038/gt.2009.125

Authors: Y Feng, F Jacobs, E Van Craeyveld, J Lievens, J Snoeys, S Van Linthout & B De Geest

The HSV-2 mutant ΔPK induces melanoma oncolysis through nonredundant death programs and associated with autophagy and pyroptosis proteins

A G Colunga — 2009-10-01

The HSV-2 mutant ΔPK induces melanoma oncolysis through nonredundant death programs and associated with autophagy and pyroptosis proteins

Gene Therapy advance online publication, October 1, 2009. doi:10.1038/gt.2009.126

Authors: A G Colunga, J M Laing & L Aurelian

Progress and prospects: gene therapy for inherited immunodeficiencies

W Qasim — 2009-07-24

Progress and prospects: gene therapy for inherited immunodeficiencies

Gene Therapy advance online publication, September 24, 2009. doi:10.1038/gt.2009.127

Authors: W Qasim, H B Gaspar & A J Thrasher

Targeting human glioma cells using HSV-1 amplicon peptide display vector

I A W Ho — 2009-10-08

Targeting human glioma cells using HSV-1 amplicon peptide display vector

Gene Therapy advance online publication, October 8, 2009. doi:10.1038/gt.2009.128

Authors: I A W Ho, L Miao, K C Sia, G Y Wang, K M Hui & P Y P Lam

Mechanisms controlling titer and expression of bidirectional lentiviral and gammaretroviral vectors

T Maetzig — 2009-10-22

Mechanisms controlling titer and expression of bidirectional lentiviral and gammaretroviral vectors

Gene Therapy advance online publication, October 22, 2009. doi:10.1038/gt.2009.129

Authors: T Maetzig, M Galla, M H Brugman, R Loew, C Baum & A Schambach

Cellular effects of oncolytic viral therapy on the glioblastoma microenvironment

P C Huszthy — 2009-10-15

Cellular effects of oncolytic viral therapy on the glioblastoma microenvironment

Gene Therapy advance online publication, October 15, 2009. doi:10.1038/gt.2009.130

Authors: P C Huszthy, H Immervoll, J Wang, D Goplen, H Miletic, G E Eide & R Bjerkvig

In vivo selection of human embryonic stem cell-derived cells expressing methotrexate-resistant dihydrofolate reductase

J L Gori — 2009-10-15

In vivo selection of human embryonic stem cell-derived cells expressing methotrexate-resistant dihydrofolate reductase

Gene Therapy advance online publication, October 15, 2009. doi:10.1038/gt.2009.131

Authors: J L Gori, X Tian, D Swanson, R Gunther, L D Shultz, R S McIvor & D S Kaufman

Lister strain vaccinia virus, a potential therapeutic vector targeting hypoxic tumours

C T Hiley — 200-11-05

Lister strain vaccinia virus, a potential therapeutic vector targeting hypoxic tumours

Gene Therapy advance online publication, November 5, 2009. doi:10.1038/gt.2009.132

Authors: C T Hiley, M Yuan, N R Lemoine & Y Wang

Chemoprotection of human hematopoietic stem cells by simultaneous lentiviral overexpression of multidrug resistance 1 and O6-methylguanine-DNA methyltransferaseP140K

P Maier — 2009-10-29

Chemoprotection of human hematopoietic stem cells by simultaneous lentiviral overexpression of multidrug resistance 1 and O6-methylguanine-DNA methyltransferaseP140K

Gene Therapy advance online publication, October 29, 2009. doi:10.1038/gt.2009.133

Authors: P Maier, I Spier, S Laufs, M R Veldwijk, S Fruehauf, F Wenz & W J Zeller

A new PG13-based packaging cell line for stable production of clinical-grade self-inactivating γ-retroviral vectors using targeted integration

R Loew — 2009-10-29

A new PG13-based packaging cell line for stable production of clinical-grade self-inactivating γ-retroviral vectors using targeted integration

Gene Therapy advance online publication, October 29, 2009. doi:10.1038/gt.2009.134

Authors: R Loew, Y Meyer, K Kuehlcke, L Gama-Norton, D Wirth, H Hauser, S Stein, M Grez, S Thornhill, A Thrasher, C Baum & A Schambach

Integrase-defective lentiviral vectors: progress and applications

M B Banasik — 2009-10-22

Integrase-defective lentiviral vectors: progress and applications

Gene Therapy advance online publication, October 22, 2009. doi:10.1038/gt.2009.135

Authors: M B Banasik & P B McCray

Effect of nuclear localization and hydrodynamic delivery-induced cell division on φC31 integrase activity

L E Woodard — 2009-10-22

Effect of nuclear localization and hydrodynamic delivery-induced cell division on φC31 integrase activity

Gene Therapy advance online publication, October 22, 2009. doi:10.1038/gt.2009.136

Authors: L E Woodard, R T Hillman, A Keravala, S Lee & M P Calos

In vitro and in vivo functional characterization of gutless recombinant SV40-derived CFTR vectors

C Mueller — 200-11-05

In vitro and in vivo functional characterization of gutless recombinant SV40-derived CFTR vectors

Gene Therapy advance online publication, November 5, 2009. doi:10.1038/gt.2009.137

Authors: C Mueller, M S Strayer, J Sirninger, S Braag, F Branco, J-P Louboutin, T R Flotte & D S Strayer

SLAM-enriched hematopoietic stem cells maintain long-term repopulating capacity after lentiviral transduction using an abbreviated protocol

P Laje — 2009-10-29

SLAM-enriched hematopoietic stem cells maintain long-term repopulating capacity after lentiviral transduction using an abbreviated protocol

Gene Therapy advance online publication, October 29, 2009. doi:10.1038/gt.2009.138

Authors: P Laje, P W Zoltick & A W Flake

Proliferating NK cells in response to IL-15 do not upregulate surface B220 in vivo

O Murillo — 2009-10-29

Proliferating NK cells in response to IL-15 do not upregulate surface B220 in vivo

Gene Therapy advance online publication, October 29, 2009. doi:10.1038/gt.2009.139

Authors: O Murillo, M C Ochoa, A Arina, I Gabari, J Dubrot, S Hervas-Stubbs & I Melero

DNA prime–protein boost increased the titer, avidity and persistence of anti-Aβ antibodies in wild-type mice

H Davtyan — 2009-10-29

DNA prime–protein boost increased the titer, avidity and persistence of anti-Aβ antibodies in wild-type mice

Gene Therapy advance online publication, October 29, 2009. doi:10.1038/gt.2009.140

Authors: H Davtyan, M Mkrtichyan, N Movsesyan, I Petrushina, G Mamikonyan, D H Cribbs, M G Agadjanyan & A Ghochikyan

DsAAV8-mediated expression of glucagon-like peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetes

M J Riedel — 2009-10-29

DsAAV8-mediated expression of glucagon-like peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetes

Gene Therapy advance online publication, October 29, 2009. doi:10.1038/gt.2009.143

Authors: M J Riedel, D F Gaddy, A Asadi, P D Robbins & T J Kieffer

Extending the transposable payload limit of Sleeping Beauty (SB) using the Herpes Simplex Virus (HSV)/SB amplicon-vector platform

S de Silva — 2009-10-29

Extending the transposable payload limit of Sleeping Beauty (SB) using the Herpes Simplex Virus (HSV)/SB amplicon-vector platform

Gene Therapy advance online publication, October 29, 2009. doi:10.1038/gt.2009.144

Authors: S de Silva, M A Mastrangelo, L T Lotta, C A Burris, H J Federoff & W J Bowers

Isolation and evaluation of novel adeno-associated virus sequences from porcine tissues

A Bello — 2009-07-23

Isolation and evaluation of novel adeno-associated virus sequences from porcine tissues

Gene Therapy advance online publication, July 23, 2009. doi:10.1038/gt.2009.82

Authors: A Bello, K Tran, A Chand, M Doria, M Allocca, M Hildinger, D Beniac, C Kranendonk, A Auricchio & G P Kobinger

Mannitol-facilitated CNS entry of rAAV2 vector significantly delayed the neurological disease progression in MPS IIIB mice

D M McCarty — 2009-07-09

Mannitol-facilitated CNS entry of rAAV2 vector significantly delayed the neurological disease progression in MPS IIIB mice

Gene Therapy advance online publication, July 9, 2009. doi:10.1038/gt.2009.85

Authors: D M McCarty, J DiRosario, K Gulaid, J Muenzer & H Fu

Transgenic expression of human gp100 and RANTES at specific time points for suppression of melanoma

K Aravindaram — 2009-07-23

Transgenic expression of human gp100 and RANTES at specific time points for suppression of melanoma

Gene Therapy advance online publication, July 23, 2009. doi:10.1038/gt.2009.90

Authors: K Aravindaram, H-H Yu, C-W Lan, P-H Wang, Y-H Chen, H-M Chen, H Yagita & N-S Yang

rAAV-mediated overexpression of FGF-2 promotes cell proliferation, survival, and α-SMA expression in human meniscal lesions

M Cucchiarini — 2009-07-30

rAAV-mediated overexpression of FGF-2 promotes cell proliferation, survival, and α-SMA expression in human meniscal lesions

Gene Therapy advance online publication, July 30, 2009. doi:10.1038/gt.2009.91

Authors: M Cucchiarini, S Schetting, E F Terwilliger, D Kohn & H Madry

Immune responses to T-cell epitopes of SARS CoV-N protein are enhanced by N immunization with a chimera of lysosome-associated membrane protein

K Yang — 2009-07-03

Immune responses to T-cell epitopes of SARS CoV-N protein are enhanced by N immunization with a chimera of lysosome-associated membrane protein

Gene Therapy advance online publication, September 3, 2009. doi:10.1038/gt.2009.92

Authors: K Yang, K Sun, K N Srinivasan, J Salmon, E T Marques, J Xu & J T August

Induction of protective cytotoxic T-cell responses by a B-cell-based cellular vaccine requires stable expression of antigen

S Guo — 2009-07-30

Induction of protective cytotoxic T-cell responses by a B-cell-based cellular vaccine requires stable expression of antigen

Gene Therapy advance online publication, July 30, 2009. doi:10.1038/gt.2009.93

Authors: S Guo, J Xu, W Denning & Z Hel

Analysis of genetically engineered oncolytic herpes simplex viruses in human prostate cancer organotypic cultures

B J Passer — 2009-07-20

Analysis of genetically engineered oncolytic herpes simplex viruses in human prostate cancer organotypic cultures

Gene Therapy advance online publication, August 20, 2009. doi:10.1038/gt.2009.94

Authors: B J Passer, C-l Wu, S Wu, S D Rabkin & R L Martuza

Systemic administration of a PEGylated adenovirus vector with a cancer-specific promoter is effective in a mouse model of metastasis

X Yao — 2009-07-30

Systemic administration of a PEGylated adenovirus vector with a cancer-specific promoter is effective in a mouse model of metastasis

Gene Therapy advance online publication, July 30, 2009. doi:10.1038/gt.2009.95

Authors: X Yao, Y Yoshioka, T Morishige, Y Eto, H Watanabe, Y Okada, H Mizuguchi, Y Mukai, N Okada & S Nakagawa

Retroviral vector integration in post-transplant hematopoiesis in mice conditioned with either submyeloablative or ablative irradiation

M A Sadat — 2009-07-06

Retroviral vector integration in post-transplant hematopoiesis in mice conditioned with either submyeloablative or ablative irradiation

Gene Therapy advance online publication, August 6, 2009. doi:10.1038/gt.2009.96

Authors: M A Sadat, S Dirscherl, L Sastry, J Dantzer, N Pech, S Griffin, T Hawkins, Y Zhao, C N Barese, S Cross, A Orazi, C An, W S Goebel, M C Yoder, X Li, M Grez, K Cornetta, S D Mooney & M C Dinauer

Efficient delivery of angiostatin K1-5 into tumors following insertion of an NGR peptide into adenovirus capsid

B Jullienne — 2009-07-30

Efficient delivery of angiostatin K1-5 into tumors following insertion of an NGR peptide into adenovirus capsid

Gene Therapy advance online publication, July 30, 2009. doi:10.1038/gt.2009.97

Authors: B Jullienne, F Vigant, E Muth, R Chaligné, C Bouquet, S Giraudier, M Perricaudet & K Benihoud

Adenoviral-mediated gene transfer restores plasma ADAMTS13 antigen and activity in ADAMTS13 knockout mice

P Trionfini — 2009-07-13

Adenoviral-mediated gene transfer restores plasma ADAMTS13 antigen and activity in ADAMTS13 knockout mice

Gene Therapy advance online publication, August 13, 2009. doi:10.1038/gt.2009.98

Authors: P Trionfini, S Tomasoni, M Galbusera, D Motto, L Longaretti, D Corna, G Remuzzi & A Benigni

Highly efficient eradication of intracranial glioblastoma using Eg5 siRNA combined with HVJ envelope

M Matsuda — 2009-07-13

Highly efficient eradication of intracranial glioblastoma using Eg5 siRNA combined with HVJ envelope

Gene Therapy advance online publication, August 13, 2009. doi:10.1038/gt.2009.99

Authors: M Matsuda, T Yamamoto, A Matsumura & Y Kaneda