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Captopril was shown to improve RAAS, oxidative stress, and inflammation, and also rebalance dysbiotic gut microbiome, firstly elucidating its hypotensive effect via reverting gut microbiome.
Differential increased cardiac expression of Cpxm2 was assigned to cardiac hypertrophy in SHRSP rats. Cpxm2 knock-out (KO) in mice reduced cardiac hypertrophy and remodeling in DOCA salt hypertension
A high uric acid level at baseline is significantly associated with an increase in systolic blood pressure over time in female individuals but not in male individuals.
*Adjusted prevalence of high office blood pressure (OBP) and home blood pressure monitoring (HBPM) before and during the Covid-19 pandemic among independent treated participants. **p < 0.05. Whisker-plot: 95% confidence interval.