Laboratory Investigation - AOP - nature.com science feeds Laboratory Investigation is the official journal of the United States and Canadian Academy of Pathology. Laboratory Investigation is available as both in print and online journal and is dedicated to the publication of original research that significantly advances the understanding of human and experimental disease including basic biology papers with a relevance to experimental or clinical aspects of disease. The journal also publishes papers detailing relevant advances in technical methodology. http://www.nature.com/labinvest/journal/vaop/ncurrent/rss.rdf Nature Publishing Group en Copyright © Nature Publishing Group Laboratory Investigation 0023-6837 Copyright © Nature Publishing Group permissions@nature.com Laboratory Investigation http://www.nature.com/aj/images/logos_b_o_w/labinvest.gif http://www.nature.com/labinvest/ Inhibition of nitric oxide synthesis during induced cholestasis ameliorates hepatocellular injury by facilitating S-nitrosothiol homeostasis http://feeds.nature.com/~r/labinvest/rss/aop/~3/B8-gtJWnPYM/labinvest.2009.104 Inhibition of nitric oxide synthesis during induced cholestasis ameliorates hepatocellular injury by facilitating S-nitrosothiol homeostasis

Laboratory Investigation advance online publication, October 5, 2009. doi:10.1038/labinvest.2009.104

Authors: Laura M López-Sánchez, Fernando J Corrales, Montserrat Barcos, Isabel Espejo, Juan R Muñoz-Castañeda & Antonio Rodríguez-Ariza

]]> Inhibition of nitric oxide synthesis during induced cholestasis ameliorates hepatocellular injury by facilitating S-nitrosothiol homeostasis Laura M López-Sánchez Fernando J Corrales Montserrat Barcos Isabel Espejo Juan R Muñoz-Castañeda Antonio Rodríguez-Ariza doi:10.1038/labinvest.2009.104 Laboratory Investigation advance online publication, October 5, 2009 2009-10-05 Laboratory Investigation October 5, 2009 10.1038/labinvest.2009.104 http://dx.doi.org/10.1038/labinvest.2009.104 aop current http://dx.doi.org/10.1038/labinvest.2009.104 Intrarenal expression of microRNAs in patients with IgA nephropathy http://feeds.nature.com/~r/labinvest/rss/aop/~3/0pIzCLbuFzQ/labinvest.2009.118 Intrarenal expression of microRNAs in patients with IgA nephropathy

Laboratory Investigation advance online publication, November 9, 2009. doi:10.1038/labinvest.2009.118

Authors: Gang Wang, Bonnie C-H Kwan, Fernand M-M Lai, Paul C-L Choi, Kai-Ming Chow, Philip K-T Li & Cheuk-Chun Szeto

]]> Intrarenal expression of microRNAs in patients with IgA nephropathy Gang Wang Bonnie C-H Kwan Fernand M-M Lai Paul C-L Choi Kai-Ming Chow Philip K-T Li Cheuk-Chun Szeto doi:10.1038/labinvest.2009.118 Laboratory Investigation advance online publication, November 9, 2009 200-11-09 Laboratory Investigation November 9, 2009 10.1038/labinvest.2009.118 http://dx.doi.org/10.1038/labinvest.2009.118 aop current http://dx.doi.org/10.1038/labinvest.2009.118 Pancreatic duodenal homeobox 1 protein is a novel β-cell-specific autoantigen for type I diabetes http://feeds.nature.com/~r/labinvest/rss/aop/~3/w4GpPPWpnsY/labinvest.2009.116 Pancreatic duodenal homeobox 1 protein is a novel β-cell-specific autoantigen for type I diabetes

Laboratory Investigation advance online publication, November 9, 2009. doi:10.1038/labinvest.2009.116

Authors: Shi-Wu Li, Vijay Koya, Yi Li, William Donelan, Peng Lin, Westley H Reeves & Li-Jun Yang

]]> Pancreatic duodenal homeobox 1 protein is a novel β-cell-specific autoantigen for type I diabetes Shi-Wu Li Vijay Koya Yi Li William Donelan Peng Lin Westley H Reeves Li-Jun Yang doi:10.1038/labinvest.2009.116 Laboratory Investigation advance online publication, November 9, 2009 200-11-09 Laboratory Investigation November 9, 2009 10.1038/labinvest.2009.116 http://dx.doi.org/10.1038/labinvest.2009.116 aop current http://dx.doi.org/10.1038/labinvest.2009.116 Nephron-deficient Fvb mice develop rapidly progressive renal failure and heavy albuminuria involving excess glomerular GLUT1 and VEGF http://feeds.nature.com/~r/labinvest/rss/aop/~3/yQPWq0vSI00/labinvest.2009.95 Nephron-deficient Fvb mice develop rapidly progressive renal failure and heavy albuminuria involving excess glomerular GLUT1 and VEGF

Laboratory Investigation advance online publication, November 16, 2009. doi:10.1038/labinvest.2009.95

Authors: Youli Wang, Kathleen O Heilig, Andrew W Minto, Shenglin Chen, Minghui Xiang, David A Dean, Richard C Geiger, Anthony Chang, Dimitrina D Pravtcheva, Martin Schlimme, Dilip K Deb, Ying Wang & Charles W Heilig

]]> Nephron-deficient Fvb mice develop rapidly progressive renal failure and heavy albuminuria involving excess glomerular GLUT1 and VEGF Youli Wang Kathleen O Heilig Andrew W Minto Shenglin Chen Minghui Xiang David A Dean Richard C Geiger Anthony Chang Dimitrina D Pravtcheva Martin Schlimme Dilip K Deb Ying Wang Charles W Heilig doi:10.1038/labinvest.2009.95 Laboratory Investigation advance online publication, November 16, 2009 200-11-16 Laboratory Investigation November 16, 2009 10.1038/labinvest.2009.95 http://dx.doi.org/10.1038/labinvest.2009.95 aop current http://dx.doi.org/10.1038/labinvest.2009.95 Acyclic retinoid inhibits angiogenesis by suppressing the MAPK pathway http://feeds.nature.com/~r/labinvest/rss/aop/~3/HPrZUS7jxkw/labinvest.2009.110 Acyclic retinoid inhibits angiogenesis by suppressing the MAPK pathway

Laboratory Investigation advance online publication, October 19, 2009. doi:10.1038/labinvest.2009.110

Authors: Yusuke Komi, Yukihisa Sogabe, Naoto Ishibashi, Yasufumi Sato, Hisataka Moriwaki, Kentaro Shimokado & Soichi Kojima

]]> Acyclic retinoid inhibits angiogenesis by suppressing the MAPK pathway Yusuke Komi Yukihisa Sogabe Naoto Ishibashi Yasufumi Sato Hisataka Moriwaki Kentaro Shimokado Soichi Kojima doi:10.1038/labinvest.2009.110 Laboratory Investigation advance online publication, October 19, 2009 2009-10-19 Laboratory Investigation October 19, 2009 10.1038/labinvest.2009.110 http://dx.doi.org/10.1038/labinvest.2009.110 aop current http://dx.doi.org/10.1038/labinvest.2009.110 Curcumin limits the fibrogenic evolution of experimental steatohepatitis http://feeds.nature.com/~r/labinvest/rss/aop/~3/IKGcH6r-WHE/labinvest.2009.112 Curcumin limits the fibrogenic evolution of experimental steatohepatitis

Laboratory Investigation advance online publication, November 9, 2009. doi:10.1038/labinvest.2009.112

Authors: Francesco Vizzutti, Angela Provenzano, Sara Galastri, Stefano Milani, Wanda Delogu, Erica Novo, Alessandra Caligiuri, Elena Zamara, Umberto Arena, Giacomo Laffi, Maurizio Parola, Massimo Pinzani & Fabio Marra

]]> Curcumin limits the fibrogenic evolution of experimental steatohepatitis Francesco Vizzutti Angela Provenzano Sara Galastri Stefano Milani Wanda Delogu Erica Novo Alessandra Caligiuri Elena Zamara Umberto Arena Giacomo Laffi Maurizio Parola Massimo Pinzani Fabio Marra doi:10.1038/labinvest.2009.112 Laboratory Investigation advance online publication, November 9, 2009 200-11-09 Laboratory Investigation November 9, 2009 10.1038/labinvest.2009.112 http://dx.doi.org/10.1038/labinvest.2009.112 aop current http://dx.doi.org/10.1038/labinvest.2009.112 Isolation of targeting nanobodies against co-opted tumor vasculature http://feeds.nature.com/~r/labinvest/rss/aop/~3/ML6efoKkrPE/labinvest.2009.107 Isolation of targeting nanobodies against co-opted tumor vasculature

Laboratory Investigation advance online publication, October 12, 2009. doi:10.1038/labinvest.2009.107

Authors: Ilse Roodink, Maarten Franssen, Malou Zuidscherwoude, Kiek Verrijp, Tom van der Donk, Jos Raats & William PJ Leenders

]]> Isolation of targeting nanobodies against co-opted tumor vasculature Ilse Roodink Maarten Franssen Malou Zuidscherwoude Kiek Verrijp Tom van der Donk Jos Raats William PJ Leenders doi:10.1038/labinvest.2009.107 Laboratory Investigation advance online publication, October 12, 2009 2009-10-12 Laboratory Investigation October 12, 2009 10.1038/labinvest.2009.107 http://dx.doi.org/10.1038/labinvest.2009.107 aop current http://dx.doi.org/10.1038/labinvest.2009.107 Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related SIRS due to the release of preformed stores in the intestine http://feeds.nature.com/~r/labinvest/rss/aop/~3/0d6l6eVBEsU/labinvest.2009.119 Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related SIRS due to the release of preformed stores in the intestine

Laboratory Investigation advance online publication, November 9, 2009. doi:10.1038/labinvest.2009.119

Authors: R Britt McILwain, Joseph G Timpa, Ashish R Kurundkar, David W Holt, David R Kelly, Yolanda E Hartman, Mary Lauren Neel, Rajendra K Karnatak, Robert L Schelonka, G M Anantharamaiah, Cheryl R Killingsworth & Akhil Maheshwari

]]> Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related SIRS due to the release of preformed stores in the intestine R Britt McILwain Joseph G Timpa Ashish R Kurundkar David W Holt David R Kelly Yolanda E Hartman Mary Lauren Neel Rajendra K Karnatak Robert L Schelonka G M Anantharamaiah Cheryl R Killingsworth Akhil Maheshwari doi:10.1038/labinvest.2009.119 Laboratory Investigation advance online publication, November 9, 2009 200-11-09 Laboratory Investigation November 9, 2009 10.1038/labinvest.2009.119 http://dx.doi.org/10.1038/labinvest.2009.119 aop current http://dx.doi.org/10.1038/labinvest.2009.119 Knockdown of FABP5 mRNA decreases cellular cholesterol levels and results in decreased apoB100 secretion and triglyceride accumulation in ARPE-19 cells http://feeds.nature.com/~r/labinvest/rss/aop/~3/Kw27bu4BeII/labinvest.2009.33 Knockdown of FABP5 mRNA decreases cellular cholesterol levels and results in decreased apoB100 secretion and triglyceride accumulation in ARPE-19 cells

Laboratory Investigation advance online publication, May 11, 2009. doi:10.1038/labinvest.2009.33

Authors: Tinghuai Wu, Jane Tian, Roy G Cutler, Richard S Telljohann, David A Bernlohr, Mark P Mattson & James T Handa

]]> Knockdown of FABP5 mRNA decreases cellular cholesterol levels and results in decreased apoB100 secretion and triglyceride accumulation in ARPE-19 cells Tinghuai Wu Jane Tian Roy G Cutler Richard S Telljohann David A Bernlohr Mark P Mattson James T Handa doi:10.1038/labinvest.2009.33 Laboratory Investigation advance online publication, May 11, 2009 2009-05-11 Laboratory Investigation May 11, 2009 10.1038/labinvest.2009.33 http://dx.doi.org/10.1038/labinvest.2009.33 aop current http://dx.doi.org/10.1038/labinvest.2009.33 FTY720, a sphingosine 1-phosphate receptor modulator, inhibits CD1d-restricted NKT cells by suppressing cytokine production but not migration http://feeds.nature.com/~r/labinvest/rss/aop/~3/Fbk_tXYolpo/labinvest.2009.109 FTY720, a sphingosine 1-phosphate receptor modulator, inhibits CD1d-restricted NKT cells by suppressing cytokine production but not migration

Laboratory Investigation advance online publication, October 12, 2009. doi:10.1038/labinvest.2009.109

Authors: Su Jin Hwang, Ji Hyung Kim, Hye Young Kim, Sanghee Kim & Doo Hyun Chung

]]> FTY720, a sphingosine 1-phosphate receptor modulator, inhibits CD1d-restricted NKT cells by suppressing cytokine production but not migration Su Jin Hwang Ji Hyung Kim Hye Young Kim Sanghee Kim Doo Hyun Chung doi:10.1038/labinvest.2009.109 Laboratory Investigation advance online publication, October 12, 2009 2009-10-12 Laboratory Investigation October 12, 2009 10.1038/labinvest.2009.109 http://dx.doi.org/10.1038/labinvest.2009.109 aop current http://dx.doi.org/10.1038/labinvest.2009.109 Erythropoietin-induced upregulation of endothelial nitric oxide synthase but not vascular endothelial growth factor prevents musculocutaneous tissue from ischemic damage http://feeds.nature.com/~r/labinvest/rss/aop/~3/2H9FpTTFEjE/labinvest.2009.117 Erythropoietin-induced upregulation of endothelial nitric oxide synthase but not vascular endothelial growth factor prevents musculocutaneous tissue from ischemic damage

Laboratory Investigation advance online publication, November 9, 2009. doi:10.1038/labinvest.2009.117

Authors: Farid Rezaeian, Reto Wettstein, Jean-François Egger, Freya Sandmann, Martin Rücker, Mickaël Tobalem, Brigitte Vollmar, Michael D Menger & Yves Harder

]]> Erythropoietin-induced upregulation of endothelial nitric oxide synthase but not vascular endothelial growth factor prevents musculocutaneous tissue from ischemic damage Farid Rezaeian Reto Wettstein Jean-François Egger Freya Sandmann Martin Rücker Mickaël Tobalem Brigitte Vollmar Michael D Menger Yves Harder doi:10.1038/labinvest.2009.117 Laboratory Investigation advance online publication, November 9, 2009 200-11-09 Laboratory Investigation November 9, 2009 10.1038/labinvest.2009.117 http://dx.doi.org/10.1038/labinvest.2009.117 aop current http://dx.doi.org/10.1038/labinvest.2009.117 Effects of sulfur dioxide on hypoxic pulmonary vascular structural remodeling http://feeds.nature.com/~r/labinvest/rss/aop/~3/lxk-TzIbGU8/labinvest.2009.102 Effects of sulfur dioxide on hypoxic pulmonary vascular structural remodeling

Laboratory Investigation advance online publication, October 12, 2009. doi:10.1038/labinvest.2009.102

Authors: Yan Sun, Yue Tian, Mainali Prabha, Die Liu, Stella Chen, Rongyuan Zhang, Xueqin Liu, Chaoshu Tang, Xiuying Tang, Hongfang Jin & Junbao Du

]]> Effects of sulfur dioxide on hypoxic pulmonary vascular structural remodeling Yan Sun Yue Tian Mainali Prabha Die Liu Stella Chen Rongyuan Zhang Xueqin Liu Chaoshu Tang Xiuying Tang Hongfang Jin Junbao Du doi:10.1038/labinvest.2009.102 Laboratory Investigation advance online publication, October 12, 2009 2009-10-12 Laboratory Investigation October 12, 2009 10.1038/labinvest.2009.102 http://dx.doi.org/10.1038/labinvest.2009.102 aop current http://dx.doi.org/10.1038/labinvest.2009.102 Rho/ROCK and MEK/ERK activation by transforming growth factor-α induces articular cartilage degradation http://feeds.nature.com/~r/labinvest/rss/aop/~3/COiOha4o3ho/labinvest.2009.111 Rho/ROCK and MEK/ERK activation by transforming growth factor-α induces articular cartilage degradation

Laboratory Investigation advance online publication, October 12, 2009. doi:10.1038/labinvest.2009.111

Authors: C Thomas G Appleton, Shirine E Usmani, John S Mort & Frank Beier

]]> Rho/ROCK and MEK/ERK activation by transforming growth factor-α induces articular cartilage degradation C Thomas G Appleton Shirine E Usmani John S Mort Frank Beier doi:10.1038/labinvest.2009.111 Laboratory Investigation advance online publication, October 12, 2009 2009-10-12 Laboratory Investigation October 12, 2009 10.1038/labinvest.2009.111 http://dx.doi.org/10.1038/labinvest.2009.111 aop current http://dx.doi.org/10.1038/labinvest.2009.111