Molecular Therapy - AOP - nature.com science feeds mt is a cross-disciplinary biomedical journal devoted to publishing the most exciting advances in pharmacology and therapeutics, as they pertain to advances in translational and clinical medicine. It is recognized as one of the most prestigious journals in the field. With an impact factor of 6.825*, mt ranks in the top 4.2% of scientific journals in the latest Science Citation Index. Published monthly online and in print. http://www.nature.com/mt/journal/vaop/ncurrent/rss.rdf Nature Publishing Group en Copyright © Nature Publishing Group Molecular Therapy 1525-0016 Copyright © Nature Publishing Group permissions@nature.com Molecular Therapy http://www.nature.com/aj/images/logos_b_o_w/mt.gif http://www.nature.com/mt/ Generation of Novel AAV Variants by Directed Evolution for Improved CFTR Delivery to Human Ciliated Airway Epithelium http://feeds.nature.com/~r/mt/rss/aop/~3/0_l1eqSInE0/mt.2009.155 Generation of Novel AAV Variants by Directed Evolution for Improved CFTR Delivery to Human Ciliated Airway Epithelium

Molecular Therapy advance online publication, July 14, 2009. doi:10.1038/mt.2009.155

Authors: Wuping Li, Liqun Zhang, Jarrod S Johnson, Wu Zhijian, Joshua C Grieger, Xiao Ping-Jie, Lauren M Drouin, Mavis Agbandje-McKenna, Raymond J Pickles & R Jude Samulski

]]> Generation of Novel AAV Variants by Directed Evolution for Improved CFTR Delivery to Human Ciliated Airway Epithelium Wuping Li Liqun Zhang Jarrod S Johnson Wu Zhijian Joshua C Grieger Xiao Ping-Jie Lauren M Drouin Mavis Agbandje-McKenna Raymond J Pickles R Jude Samulski doi:10.1038/mt.2009.155 Molecular Therapy advance online publication, July 14, 2009 2009-07-14 Molecular Therapy July 14, 2009 10.1038/mt.2009.155 http://dx.doi.org/10.1038/mt.2009.155 aop current http://dx.doi.org/10.1038/mt.2009.155 Design and Evaluation of Doxorubicin-containing Microbubbles for Ultrasound-triggered Doxorubicin Delivery: Cytotoxicity and Mechanisms Involved http://feeds.nature.com/~r/mt/rss/aop/~3/aKwA4FbLWRQ/mt.2009.160 Design and Evaluation of Doxorubicin-containing Microbubbles for Ultrasound-triggered Doxorubicin Delivery: Cytotoxicity and Mechanisms Involved

Molecular Therapy advance online publication, July 21, 2009. doi:10.1038/mt.2009.160

Authors: Ine Lentacker, Bart Geers, Joseph Demeester, Stefaan C De Smedt & Niek N Sanders

]]> Design and Evaluation of Doxorubicin-containing Microbubbles for Ultrasound-triggered Doxorubicin Delivery: Cytotoxicity and Mechanisms Involved Ine Lentacker Bart Geers Joseph Demeester Stefaan C De Smedt Niek N Sanders doi:10.1038/mt.2009.160 Molecular Therapy advance online publication, July 21, 2009 2009-07-21 Molecular Therapy July 21, 2009 10.1038/mt.2009.160 http://dx.doi.org/10.1038/mt.2009.160 aop current http://dx.doi.org/10.1038/mt.2009.160 Targeting a Dominant Negative Rho Kinase to Neurons Promotes Axonal Outgrowth and Partial Functional Recovery After Rat Rubrospinal Tract Lesion http://feeds.nature.com/~r/mt/rss/aop/~3/Kr9ZDNWL0nM/mt.2009.168 Targeting a Dominant Negative Rho Kinase to Neurons Promotes Axonal Outgrowth and Partial Functional Recovery After Rat Rubrospinal Tract Lesion

Molecular Therapy advance online publication, July 21, 2009. doi:10.1038/mt.2009.168

Authors: Dongsheng Wu, Ping Yang, Xinyu Zhang, Juan Luo, Mohammed E Haque, John Yeh, Peter M Richardson, Yi Zhang & Xuenong Bo

]]> Targeting a Dominant Negative Rho Kinase to Neurons Promotes Axonal Outgrowth and Partial Functional Recovery After Rat Rubrospinal Tract Lesion Dongsheng Wu Ping Yang Xinyu Zhang Juan Luo Mohammed E Haque John Yeh Peter M Richardson Yi Zhang Xuenong Bo doi:10.1038/mt.2009.168 Molecular Therapy advance online publication, July 21, 2009 2009-07-21 Molecular Therapy July 21, 2009 10.1038/mt.2009.168 http://dx.doi.org/10.1038/mt.2009.168 aop current http://dx.doi.org/10.1038/mt.2009.168 Cationic Lipid Formulations Alter the In Vivo Tropism of AAV2/9 Vector in Lung http://feeds.nature.com/~r/mt/rss/aop/~3/yyX28Kpx41g/mt.2009.173 Cationic Lipid Formulations Alter the In Vivo Tropism of AAV2/9 Vector in Lung

Molecular Therapy advance online publication, July 28, 2009. doi:10.1038/mt.2009.173

Authors: David E Fein, Maria P Limberis, Sean F Maloney, Jack M Heath, James M Wilson & Scott L Diamond

]]> Cationic Lipid Formulations Alter the In Vivo Tropism of AAV2/9 Vector in Lung David E Fein Maria P Limberis Sean F Maloney Jack M Heath James M Wilson Scott L Diamond doi:10.1038/mt.2009.173 Molecular Therapy advance online publication, July 28, 2009 2009-07-28 Molecular Therapy July 28, 2009 10.1038/mt.2009.173 http://dx.doi.org/10.1038/mt.2009.173 aop current http://dx.doi.org/10.1038/mt.2009.173 Generating Differentially Targeted Amyloid-β Specific Intrabodies as a Passive Vaccination Strategy for Alzheimer's Disease http://feeds.nature.com/~r/mt/rss/aop/~3/gjBq2jXPtZ8/mt.2009.174 Generating Differentially Targeted Amyloid-β Specific Intrabodies as a Passive Vaccination Strategy for Alzheimer's Disease

Molecular Therapy advance online publication, July 28, 2009. doi:10.1038/mt.2009.174

Authors: Kelly L Sudol, Michael A Mastrangelo, Wade C Narrow, Maria E Frazer, Yona R Levites, Todd E Golde, Howard J Federoff & William J Bowers

]]> Generating Differentially Targeted Amyloid-β Specific Intrabodies as a Passive Vaccination Strategy for Alzheimer's Disease Kelly L Sudol Michael A Mastrangelo Wade C Narrow Maria E Frazer Yona R Levites Todd E Golde Howard J Federoff William J Bowers doi:10.1038/mt.2009.174 Molecular Therapy advance online publication, July 28, 2009 2009-07-28 Molecular Therapy July 28, 2009 10.1038/mt.2009.174 http://dx.doi.org/10.1038/mt.2009.174 aop current http://dx.doi.org/10.1038/mt.2009.174 Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease http://feeds.nature.com/~r/mt/rss/aop/~3/9RFIJJuCiMM/mt.2009.175 Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease

Molecular Therapy advance online publication, August 4, 2009. doi:10.1038/mt.2009.175

Authors: Eloise Hudry, Debby Van Dam, Wim Kulik, Peter P De Deyn, Femke S Stet, Ornella Ahouansou, Abdellatif Benraiss, André Delacourte, Pierre Bougnères, Patrick Aubourg & Nathalie Cartier

]]> Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease Eloise Hudry Debby Van Dam Wim Kulik Peter P De Deyn Femke S Stet Ornella Ahouansou Abdellatif Benraiss André Delacourte Pierre Bougnères Patrick Aubourg Nathalie Cartier doi:10.1038/mt.2009.175 Molecular Therapy advance online publication, August 4, 2009 2009-07-04 Molecular Therapy August 4, 2009 10.1038/mt.2009.175 http://dx.doi.org/10.1038/mt.2009.175 aop current http://dx.doi.org/10.1038/mt.2009.175 Deficiency of the Housekeeping Gene Hypoxanthine–Guanine Phosphoribosyltransferase (HPRT) Dysregulates Neurogenesis http://feeds.nature.com/~r/mt/rss/aop/~3/d11dwln-zVQ/mt.2009.178 Deficiency of the Housekeeping Gene Hypoxanthine–Guanine Phosphoribosyltransferase (HPRT) Dysregulates Neurogenesis

Molecular Therapy advance online publication, August 11, 2009. doi:10.1038/mt.2009.178

Authors: Ghiabe-Henri Guibinga, Stephen Hsu & Theodore Friedmann

]]> Deficiency of the Housekeeping Gene Hypoxanthine–Guanine Phosphoribosyltransferase (HPRT) Dysregulates Neurogenesis Ghiabe-Henri Guibinga Stephen Hsu Theodore Friedmann doi:10.1038/mt.2009.178 Molecular Therapy advance online publication, August 11, 2009 2009-07-11 Molecular Therapy August 11, 2009 10.1038/mt.2009.178 http://dx.doi.org/10.1038/mt.2009.178 aop current http://dx.doi.org/10.1038/mt.2009.178 Inner Limiting Membrane Barriers to AAV-mediated Retinal Transduction From the Vitreous http://feeds.nature.com/~r/mt/rss/aop/~3/DA7JBpDq10s/mt.2009.181 Inner Limiting Membrane Barriers to AAV-mediated Retinal Transduction From the Vitreous

Molecular Therapy advance online publication, August 11, 2009. doi:10.1038/mt.2009.181

Authors: Deniz Dalkara, Kathleen D Kolstad, Natalia Caporale, Meike Visel, Ryan R Klimczak, David V Schaffer & John G Flannery

]]> Inner Limiting Membrane Barriers to AAV-mediated Retinal Transduction From the Vitreous Deniz Dalkara Kathleen D Kolstad Natalia Caporale Meike Visel Ryan R Klimczak David V Schaffer John G Flannery doi:10.1038/mt.2009.181 Molecular Therapy advance online publication, August 11, 2009 2009-07-11 Molecular Therapy August 11, 2009 10.1038/mt.2009.181 http://dx.doi.org/10.1038/mt.2009.181 aop current http://dx.doi.org/10.1038/mt.2009.181 Molecular Evolution of Adeno-associated Virus for Enhanced Glial Gene Delivery http://feeds.nature.com/~r/mt/rss/aop/~3/DnCVJEzdmrQ/mt.2009.184 Molecular Evolution of Adeno-associated Virus for Enhanced Glial Gene Delivery

Molecular Therapy advance online publication, August 11, 2009. doi:10.1038/mt.2009.184

Authors: James T Koerber, Ryan Klimczak, Jae-Hyung Jang, Deniz Dalkara, John G Flannery & David V Schaffer

]]> Molecular Evolution of Adeno-associated Virus for Enhanced Glial Gene Delivery James T Koerber Ryan Klimczak Jae-Hyung Jang Deniz Dalkara John G Flannery David V Schaffer doi:10.1038/mt.2009.184 Molecular Therapy advance online publication, August 11, 2009 2009-07-11 Molecular Therapy August 11, 2009 10.1038/mt.2009.184 http://dx.doi.org/10.1038/mt.2009.184 aop current http://dx.doi.org/10.1038/mt.2009.184 Preintegration HIV-1 Inhibition by a Combination Lentiviral Vector Containing a Chimeric TRIM5α Protein, a CCR5 shRNA, and a TAR Decoy http://feeds.nature.com/~r/mt/rss/aop/~3/TLKG_KR789M/mt.2009.187 Preintegration HIV-1 Inhibition by a Combination Lentiviral Vector Containing a Chimeric TRIM5α Protein, a CCR5 shRNA, and a TAR Decoy

Molecular Therapy advance online publication, August 18, 2009. doi:10.1038/mt.2009.187

Authors: Joseph S Anderson, John Javien, Jan A Nolta & Gerhard Bauer

]]> Preintegration HIV-1 Inhibition by a Combination Lentiviral Vector Containing a Chimeric TRIM5α Protein, a CCR5 shRNA, and a TAR Decoy Joseph S Anderson John Javien Jan A Nolta Gerhard Bauer doi:10.1038/mt.2009.187 Molecular Therapy advance online publication, August 18, 2009 2009-07-18 Molecular Therapy August 18, 2009 10.1038/mt.2009.187 http://dx.doi.org/10.1038/mt.2009.187 aop current http://dx.doi.org/10.1038/mt.2009.187 Activation of Transgene-specific T Cells Following Lentivirus-mediated Gene Delivery to Mouse Lung http://feeds.nature.com/~r/mt/rss/aop/~3/a7LS-hx7Ejk/mt.2009.190 Activation of Transgene-specific T Cells Following Lentivirus-mediated Gene Delivery to Mouse Lung

Molecular Therapy advance online publication, September 1, 2009. doi:10.1038/mt.2009.190

Authors: Maria P Limberis, Christie L Bell, Jack Heath & James M Wilson

]]> Activation of Transgene-specific T Cells Following Lentivirus-mediated Gene Delivery to Mouse Lung Maria P Limberis Christie L Bell Jack Heath James M Wilson doi:10.1038/mt.2009.190 Molecular Therapy advance online publication, September 1, 2009 2009-07-01 Molecular Therapy September 1, 2009 10.1038/mt.2009.190 http://dx.doi.org/10.1038/mt.2009.190 aop current http://dx.doi.org/10.1038/mt.2009.190 Immunomodulatory Gene Therapy Prevents Antibody Formation and Lethal Hypersensitivity Reactions in Murine Pompe Disease http://feeds.nature.com/~r/mt/rss/aop/~3/f9YhucVcIug/mt.2009.195 Immunomodulatory Gene Therapy Prevents Antibody Formation and Lethal Hypersensitivity Reactions in Murine Pompe Disease

Molecular Therapy advance online publication, August 18, 2009. doi:10.1038/mt.2009.195

Authors: Baodong Sun, Michael D Kulis, Sarah P Young, Amy C Hobeika, Songtao Li, Andrew Bird, Haoyue Zhang, Yifan Li, Timothy M Clay, Wesley Burks, Priya S Kishnani & Dwight D Koeberl

]]> Immunomodulatory Gene Therapy Prevents Antibody Formation and Lethal Hypersensitivity Reactions in Murine Pompe Disease Baodong Sun Michael D Kulis Sarah P Young Amy C Hobeika Songtao Li Andrew Bird Haoyue Zhang Yifan Li Timothy M Clay Wesley Burks Priya S Kishnani Dwight D Koeberl doi:10.1038/mt.2009.195 Molecular Therapy advance online publication, August 18, 2009 2009-07-18 Molecular Therapy August 18, 2009 10.1038/mt.2009.195 http://dx.doi.org/10.1038/mt.2009.195 aop current http://dx.doi.org/10.1038/mt.2009.195 Genetic-induced Variations in the GAD65 T-cell Repertoire Governs Efficacy of Anti-CD3/GAD65 Combination Therapy in New-onset Type 1 Diabetes http://feeds.nature.com/~r/mt/rss/aop/~3/tKGzbjKSUDM/mt.2009.197 Genetic-induced Variations in the GAD65 T-cell Repertoire Governs Efficacy of Anti-CD3/GAD65 Combination Therapy in New-onset Type 1 Diabetes

Molecular Therapy advance online publication, August 18, 2009. doi:10.1038/mt.2009.197

Authors: Damien Bresson, Matthew Fradkin, Yulia Manenkova, Diane Rottembourg & Matthias von Herrath

]]> Genetic-induced Variations in the GAD65 T-cell Repertoire Governs Efficacy of Anti-CD3/GAD65 Combination Therapy in New-onset Type 1 Diabetes Damien Bresson Matthew Fradkin Yulia Manenkova Diane Rottembourg Matthias von Herrath doi:10.1038/mt.2009.197 Molecular Therapy advance online publication, August 18, 2009 2009-07-18 Molecular Therapy August 18, 2009 10.1038/mt.2009.197 http://dx.doi.org/10.1038/mt.2009.197 aop current http://dx.doi.org/10.1038/mt.2009.197 Multiple Functions of the 37/67-kd Laminin Receptor Make It a Suitable Target for Novel Cancer Gene Therapy http://feeds.nature.com/~r/mt/rss/aop/~3/EfS-vqx4cKY/mt.2009.199 Multiple Functions of the 37/67-kd Laminin Receptor Make It a Suitable Target for Novel Cancer Gene Therapy

Molecular Therapy advance online publication, September 1, 2009. doi:10.1038/mt.2009.199

Authors: Jonathan Scheiman, Jen-Chieh Tseng, Yun Zheng & Daniel Meruelo

]]> Multiple Functions of the 37/67-kd Laminin Receptor Make It a Suitable Target for Novel Cancer Gene Therapy Jonathan Scheiman Jen-Chieh Tseng Yun Zheng Daniel Meruelo doi:10.1038/mt.2009.199 Molecular Therapy advance online publication, September 1, 2009 2009-07-01 Molecular Therapy September 1, 2009 10.1038/mt.2009.199 http://dx.doi.org/10.1038/mt.2009.199 aop current http://dx.doi.org/10.1038/mt.2009.199 Rescue of Pyruvate Kinase Deficiency in Mice by Gene Therapy Using the Human Isoenzyme http://feeds.nature.com/~r/mt/rss/aop/~3/QxvgcUOZN8I/mt.2009.200 Rescue of Pyruvate Kinase Deficiency in Mice by Gene Therapy Using the Human Isoenzyme

Molecular Therapy advance online publication, September 15, 2009. doi:10.1038/mt.2009.200

Authors: Nestor W Meza, Maria E Alonso-Ferrero, Susana Navarro, Oscar Quintana-Bustamante, Antonio Valeri, Maria Garcia-Gomez, Juan A Bueren, Jose M Bautista & Jose C Segovia

]]> Rescue of Pyruvate Kinase Deficiency in Mice by Gene Therapy Using the Human Isoenzyme Nestor W Meza Maria E Alonso-Ferrero Susana Navarro Oscar Quintana-Bustamante Antonio Valeri Maria Garcia-Gomez Juan A Bueren Jose M Bautista Jose C Segovia doi:10.1038/mt.2009.200 Molecular Therapy advance online publication, September 15, 2009 2009-07-15 Molecular Therapy September 15, 2009 10.1038/mt.2009.200 http://dx.doi.org/10.1038/mt.2009.200 aop current http://dx.doi.org/10.1038/mt.2009.200 Induction of Tumor-specific Immune Response by Gene Transfer of Hsp70-cell-penetrating Peptide Fusion Protein to Tumors in Mice http://feeds.nature.com/~r/mt/rss/aop/~3/uYG3Xi8_9zo/mt.2009.203 Induction of Tumor-specific Immune Response by Gene Transfer of Hsp70-cell-penetrating Peptide Fusion Protein to Tumors in Mice

Molecular Therapy advance online publication, September 1, 2009. doi:10.1038/mt.2009.203

Authors: Makiya Nishikawa, Takayuki Otsuki, Atsushi Ota, Xin Guan, Seiji Takemoto, Yuki Takahashi & Yoshinobu Takakura

]]> Induction of Tumor-specific Immune Response by Gene Transfer of Hsp70-cell-penetrating Peptide Fusion Protein to Tumors in Mice Makiya Nishikawa Takayuki Otsuki Atsushi Ota Xin Guan Seiji Takemoto Yuki Takahashi Yoshinobu Takakura doi:10.1038/mt.2009.203 Molecular Therapy advance online publication, September 1, 2009 2009-07-01 Molecular Therapy September 1, 2009 10.1038/mt.2009.203 http://dx.doi.org/10.1038/mt.2009.203 aop current http://dx.doi.org/10.1038/mt.2009.203 Therapeutic and Tumor-specific Immunity Induced by Combination of Dendritic Cells and Oncolytic Adenovirus Expressing IL-12 and 4-1BBL http://feeds.nature.com/~r/mt/rss/aop/~3/wpxn0HY__tE/mt.2009.205 Therapeutic and Tumor-specific Immunity Induced by Combination of Dendritic Cells and Oncolytic Adenovirus Expressing IL-12 and 4-1BBL

Molecular Therapy advance online publication, September 8, 2009. doi:10.1038/mt.2009.205

Authors: Jing-Hua Huang, Song-Nan Zhang, Kyung-Ju Choi, Il-Kyu Choi, Joo-Hang Kim, Mingul Lee, Hoguen Kim & Chae-Ok Yun

]]> Therapeutic and Tumor-specific Immunity Induced by Combination of Dendritic Cells and Oncolytic Adenovirus Expressing IL-12 and 4-1BBL Jing-Hua Huang Song-Nan Zhang Kyung-Ju Choi Il-Kyu Choi Joo-Hang Kim Mingul Lee Hoguen Kim Chae-Ok Yun doi:10.1038/mt.2009.205 Molecular Therapy advance online publication, September 8, 2009 2009-07-08 Molecular Therapy September 8, 2009 10.1038/mt.2009.205 http://dx.doi.org/10.1038/mt.2009.205 aop current http://dx.doi.org/10.1038/mt.2009.205 Image-guided, Intravascular Hydrodynamic Gene Delivery to Skeletal Muscle in Pigs http://feeds.nature.com/~r/mt/rss/aop/~3/M9lhlakMFjc/mt.2009.206 Image-guided, Intravascular Hydrodynamic Gene Delivery to Skeletal Muscle in Pigs

Molecular Therapy advance online publication, September 8, 2009. doi:10.1038/mt.2009.206

Authors: Kenya Kamimura, Guisheng Zhang & Dexi Liu

]]> Image-guided, Intravascular Hydrodynamic Gene Delivery to Skeletal Muscle in Pigs Kenya Kamimura Guisheng Zhang Dexi Liu doi:10.1038/mt.2009.206 Molecular Therapy advance online publication, September 8, 2009 2009-07-08 Molecular Therapy September 8, 2009 10.1038/mt.2009.206 http://dx.doi.org/10.1038/mt.2009.206 aop current http://dx.doi.org/10.1038/mt.2009.206 Systemic Delivery of Synthetic MicroRNA-16 Inhibits the Growth of Metastatic Prostate Tumors via Downregulation of Multiple Cell-cycle Genes http://feeds.nature.com/~r/mt/rss/aop/~3/l8Q7XGOgGQM/mt.2009.207 Systemic Delivery of Synthetic MicroRNA-16 Inhibits the Growth of Metastatic Prostate Tumors via Downregulation of Multiple Cell-cycle Genes

Molecular Therapy advance online publication, September 8, 2009. doi:10.1038/mt.2009.207

Authors: Fumitaka Takeshita, Lubna Patrawala, Mitsuhiko Osaki, Ryou-u Takahashi, Yusuke Yamamoto, Nobuyoshi Kosaka, Masaki Kawamata, Kevin Kelnar, Andreas G. Bader, David Brown & Takahiro Ochiya

]]> Systemic Delivery of Synthetic MicroRNA-16 Inhibits the Growth of Metastatic Prostate Tumors via Downregulation of Multiple Cell-cycle Genes Fumitaka Takeshita Lubna Patrawala Mitsuhiko Osaki Ryou-u Takahashi Yusuke Yamamoto Nobuyoshi Kosaka Masaki Kawamata Kevin Kelnar Andreas G. Bader David Brown Takahiro Ochiya doi:10.1038/mt.2009.207 Molecular Therapy advance online publication, September 8, 2009 2009-07-08 Molecular Therapy September 8, 2009 10.1038/mt.2009.207 http://dx.doi.org/10.1038/mt.2009.207 aop current http://dx.doi.org/10.1038/mt.2009.207 Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment http://feeds.nature.com/~r/mt/rss/aop/~3/OnbDYAz35A8/mt.2009.208 Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment

Molecular Therapy advance online publication, September 8, 2009. doi:10.1038/mt.2009.208

Authors: Marc T Abrams, Martin L Koser, Jessica Seitzer, Stephanie C Williams, Martha A DiPietro, Weimin Wang, Andrew W Shaw, Xianzhi Mao, Vasant Jadhav, Joseph P Davide, Paul A Burke, Alan B Sachs, Steven M Stirdivant & Laura Sepp-Lorenzino

]]> Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment Marc T Abrams Martin L Koser Jessica Seitzer Stephanie C Williams Martha A DiPietro Weimin Wang Andrew W Shaw Xianzhi Mao Vasant Jadhav Joseph P Davide Paul A Burke Alan B Sachs Steven M Stirdivant Laura Sepp-Lorenzino doi:10.1038/mt.2009.208 Molecular Therapy advance online publication, September 8, 2009 2009-07-08 Molecular Therapy September 8, 2009 10.1038/mt.2009.208 http://dx.doi.org/10.1038/mt.2009.208 aop current http://dx.doi.org/10.1038/mt.2009.208 Suppression of FVIII Inhibitor Formation in Hemophilic Mice by Delivery of Transgene Modified Apoptotic Fibroblasts http://feeds.nature.com/~r/mt/rss/aop/~3/_pV-ISR6YfA/mt.2009.209 Suppression of FVIII Inhibitor Formation in Hemophilic Mice by Delivery of Transgene Modified Apoptotic Fibroblasts

Molecular Therapy advance online publication, September 15, 2009. doi:10.1038/mt.2009.209

Authors: Rui-Jun Su, Angela Epp, Yvette Latchman, Doug Bolgiano, Steven W Pipe & Neil C Josephson

]]> Suppression of FVIII Inhibitor Formation in Hemophilic Mice by Delivery of Transgene Modified Apoptotic Fibroblasts Rui-Jun Su Angela Epp Yvette Latchman Doug Bolgiano Steven W Pipe Neil C Josephson doi:10.1038/mt.2009.209 Molecular Therapy advance online publication, September 15, 2009 2009-07-15 Molecular Therapy September 15, 2009 10.1038/mt.2009.209 http://dx.doi.org/10.1038/mt.2009.209 aop current http://dx.doi.org/10.1038/mt.2009.209 Chimeric Antigen Receptors Combining 4-1BB and CD28 Signaling Domains Augment PI3kinase/AKT/Bcl-XL Activation and CD8+ T Cell–mediated Tumor Eradication http://feeds.nature.com/~r/mt/rss/aop/~3/kFFHTITb_Sg/mt.2009.210 Chimeric Antigen Receptors Combining 4-1BB and CD28 Signaling Domains Augment PI3kinase/AKT/Bcl-XL Activation and CD8+ T Cell–mediated Tumor Eradication

Molecular Therapy advance online publication, September 22, 2009. doi:10.1038/mt.2009.210

Authors: Xiao-Song Zhong, Maiko Matsushita, Jason Plotkin, Isabelle Riviere & Michel Sadelain

]]> Chimeric Antigen Receptors Combining 4-1BB and CD28 Signaling Domains Augment PI3kinase/AKT/Bcl-XL Activation and CD8+ T Cell–mediated Tumor Eradication Xiao-Song Zhong Maiko Matsushita Jason Plotkin Isabelle Riviere Michel Sadelain doi:10.1038/mt.2009.210 Molecular Therapy advance online publication, September 22, 2009 2009-07-22 Molecular Therapy September 22, 2009 10.1038/mt.2009.210 http://dx.doi.org/10.1038/mt.2009.210 aop current http://dx.doi.org/10.1038/mt.2009.210 IRES-based Vector Coexpressing FGF2 and Cyr61 Provides Synergistic and Safe Therapeutics of Lower Limb Ischemia http://feeds.nature.com/~r/mt/rss/aop/~3/3eWWNDLExkc/mt.2009.211 IRES-based Vector Coexpressing FGF2 and Cyr61 Provides Synergistic and Safe Therapeutics of Lower Limb Ischemia

Molecular Therapy advance online publication, September 8, 2009. doi:10.1038/mt.2009.211

Authors: Audrey Rayssac, Charles Neveu, Mélanie Pucelle, Loïc Van den Berghe, Leonel Prado-Lourenco, Jean-François Arnal, Xavier Chaufour & Anne-Catherine Prats

]]> IRES-based Vector Coexpressing FGF2 and Cyr61 Provides Synergistic and Safe Therapeutics of Lower Limb Ischemia Audrey Rayssac Charles Neveu Mélanie Pucelle Loïc Van den Berghe Leonel Prado-Lourenco Jean-François Arnal Xavier Chaufour Anne-Catherine Prats doi:10.1038/mt.2009.211 Molecular Therapy advance online publication, September 8, 2009 2009-07-08 Molecular Therapy September 8, 2009 10.1038/mt.2009.211 http://dx.doi.org/10.1038/mt.2009.211 aop current http://dx.doi.org/10.1038/mt.2009.211 Differential Transduction Following Basal Ganglia Administration of Distinct Pseudotyped AAV Capsid Serotypes in Nonhuman Primates http://feeds.nature.com/~r/mt/rss/aop/~3/0y_LSkmLWX8/mt.2009.216 Differential Transduction Following Basal Ganglia Administration of Distinct Pseudotyped AAV Capsid Serotypes in Nonhuman Primates

Molecular Therapy advance online publication, September 22, 2009. doi:10.1038/mt.2009.216

Authors: Hemraj B Dodiya, Tomas Bjorklund, James Stansell III, Ronald J Mandel, Deniz Kirik & Jeffrey H Kordower

]]> Differential Transduction Following Basal Ganglia Administration of Distinct Pseudotyped AAV Capsid Serotypes in Nonhuman Primates Hemraj B Dodiya Tomas Bjorklund James Stansell III Ronald J Mandel Deniz Kirik Jeffrey H Kordower doi:10.1038/mt.2009.216 Molecular Therapy advance online publication, September 22, 2009 2009-07-22 Molecular Therapy September 22, 2009 10.1038/mt.2009.216 http://dx.doi.org/10.1038/mt.2009.216 aop current http://dx.doi.org/10.1038/mt.2009.216 Expanded Anticancer Therapeutic Window of Hexon-modified Oncolytic Adenovirus http://feeds.nature.com/~r/mt/rss/aop/~3/CqQ6EytBqEg/mt.2009.217 Expanded Anticancer Therapeutic Window of Hexon-modified Oncolytic Adenovirus

Molecular Therapy advance online publication, September 15, 2009. doi:10.1038/mt.2009.217

Authors: Elena V Shashkova, Shannon M May, Konstantin Doronin & Michael A Barry

]]> Expanded Anticancer Therapeutic Window of Hexon-modified Oncolytic Adenovirus Elena V Shashkova Shannon M May Konstantin Doronin Michael A Barry doi:10.1038/mt.2009.217 Molecular Therapy advance online publication, September 15, 2009 2009-07-15 Molecular Therapy September 15, 2009 10.1038/mt.2009.217 http://dx.doi.org/10.1038/mt.2009.217 aop current http://dx.doi.org/10.1038/mt.2009.217 Noninvasive Imaging and Radiovirotherapy of Prostate Cancer Using an Oncolytic Measles Virus Expressing the Sodium Iodide Symporter http://feeds.nature.com/~r/mt/rss/aop/~3/R6fZNrokElc/mt.2009.218 Noninvasive Imaging and Radiovirotherapy of Prostate Cancer Using an Oncolytic Measles Virus Expressing the Sodium Iodide Symporter

Molecular Therapy advance online publication, September 22, 2009. doi:10.1038/mt.2009.218

Authors: Pavlos Msaouel, Ianko D Iankov, Cory Allen, Ileana Aderca, Mark J Federspiel, Donald J Tindall, John C Morris, Michael Koutsilieris, Stephen J Russell & Evanthia Galanis

]]> Noninvasive Imaging and Radiovirotherapy of Prostate Cancer Using an Oncolytic Measles Virus Expressing the Sodium Iodide Symporter Pavlos Msaouel Ianko D Iankov Cory Allen Ileana Aderca Mark J Federspiel Donald J Tindall John C Morris Michael Koutsilieris Stephen J Russell Evanthia Galanis doi:10.1038/mt.2009.218 Molecular Therapy advance online publication, September 22, 2009 2009-07-22 Molecular Therapy September 22, 2009 10.1038/mt.2009.218 http://dx.doi.org/10.1038/mt.2009.218 aop current http://dx.doi.org/10.1038/mt.2009.218 G-rich Oligonucleotides Inhibit HIF-1α and HIF-2α and Block Tumor Growth http://feeds.nature.com/~r/mt/rss/aop/~3/8sOa0hGCR6M/mt.2009.219 G-rich Oligonucleotides Inhibit HIF-1α and HIF-2α and Block Tumor Growth

Molecular Therapy advance online publication, September 15, 2009. doi:10.1038/mt.2009.219

Authors: Yongli Guan, Kavitha Ramasamy Reddy, Qiqing Zhu, Yifei Li, KangAe Lee, Priya Weerasinghe, Josef Prchal, Gregg L Semenza & Naijie Jing

]]> G-rich Oligonucleotides Inhibit HIF-1α and HIF-2α and Block Tumor Growth Yongli Guan Kavitha Ramasamy Reddy Qiqing Zhu Yifei Li KangAe Lee Priya Weerasinghe Josef Prchal Gregg L Semenza Naijie Jing doi:10.1038/mt.2009.219 Molecular Therapy advance online publication, September 15, 2009 2009-07-15 Molecular Therapy September 15, 2009 10.1038/mt.2009.219 http://dx.doi.org/10.1038/mt.2009.219 aop current http://dx.doi.org/10.1038/mt.2009.219 The Pharmacological Chaperone 1-Deoxygalactonojirimycin Reduces Tissue Globotriaosylceramide Levels in a Mouse Model of Fabry Disease http://feeds.nature.com/~r/mt/rss/aop/~3/vZlO1MuR1O0/mt.2009.220 The Pharmacological Chaperone 1-Deoxygalactonojirimycin Reduces Tissue Globotriaosylceramide Levels in a Mouse Model of Fabry Disease

Molecular Therapy advance online publication, September 22, 2009. doi:10.1038/mt.2009.220

Authors: Richie Khanna, Rebecca Soska, Yi Lun, Jessie Feng, Michelle Frascella, Brandy Young, Nastry Brignol, Lee Pellegrino, Sheela A Sitaraman, Robert J Desnick, Elfrida R Benjamin, David J Lockhart & Kenneth J Valenzano

]]> The Pharmacological Chaperone 1-Deoxygalactonojirimycin Reduces Tissue Globotriaosylceramide Levels in a Mouse Model of Fabry Disease Richie Khanna Rebecca Soska Yi Lun Jessie Feng Michelle Frascella Brandy Young Nastry Brignol Lee Pellegrino Sheela A Sitaraman Robert J Desnick Elfrida R Benjamin David J Lockhart Kenneth J Valenzano doi:10.1038/mt.2009.220 Molecular Therapy advance online publication, September 22, 2009 2009-07-22 Molecular Therapy September 22, 2009 10.1038/mt.2009.220 http://dx.doi.org/10.1038/mt.2009.220 aop current http://dx.doi.org/10.1038/mt.2009.220 Abrogation of Local Cancer Recurrence After Radiofrequency Ablation by Dendritic Cell-based Hyperthermic Tumor Vaccine http://feeds.nature.com/~r/mt/rss/aop/~3/8s2fLtMbwDs/mt.2009.221 Abrogation of Local Cancer Recurrence After Radiofrequency Ablation by Dendritic Cell-based Hyperthermic Tumor Vaccine

Molecular Therapy advance online publication, September 22, 2009. doi:10.1038/mt.2009.221

Authors: Qiong Liu, Bo Zhai, Wen Yang, Le-Xing Yu, Wei Dong, Ya-Qin He, Lei Chen, Liang Tang, Yan Lin, Dan-Dan Huang, Hong-Ping Wu, Meng-Chao Wu, He-Xin Yan & Hong-Yang Wang

]]> Abrogation of Local Cancer Recurrence After Radiofrequency Ablation by Dendritic Cell-based Hyperthermic Tumor Vaccine Qiong Liu Bo Zhai Wen Yang Le-Xing Yu Wei Dong Ya-Qin He Lei Chen Liang Tang Yan Lin Dan-Dan Huang Hong-Ping Wu Meng-Chao Wu He-Xin Yan Hong-Yang Wang doi:10.1038/mt.2009.221 Molecular Therapy advance online publication, September 22, 2009 2009-07-22 Molecular Therapy September 22, 2009 10.1038/mt.2009.221 http://dx.doi.org/10.1038/mt.2009.221 aop current http://dx.doi.org/10.1038/mt.2009.221 Low-level shRNA Cytotoxicity Can Contribute to MYC-induced Hepatocellular Carcinoma in Adult Mice http://feeds.nature.com/~r/mt/rss/aop/~3/sUs7LF1LESg/mt.2009.222 Low-level shRNA Cytotoxicity Can Contribute to MYC-induced Hepatocellular Carcinoma in Adult Mice

Molecular Therapy advance online publication, October 20, 2009. doi:10.1038/mt.2009.222

Authors: Shelly Beer, David I Bellovin, Joyce S Lee, Kimberly Komatsubara, Lora S Wang, Huishan Koh, Kathleen Börner, Theresa A Storm, Corrine R Davis, Mark A Kay, Dean W Felsher & Dirk Grimm

]]> Low-level shRNA Cytotoxicity Can Contribute to MYC-induced Hepatocellular Carcinoma in Adult Mice Shelly Beer David I Bellovin Joyce S Lee Kimberly Komatsubara Lora S Wang Huishan Koh Kathleen Börner Theresa A Storm Corrine R Davis Mark A Kay Dean W Felsher Dirk Grimm doi:10.1038/mt.2009.222 Molecular Therapy advance online publication, October 20, 2009 2009-10-20 Molecular Therapy October 20, 2009 10.1038/mt.2009.222 http://dx.doi.org/10.1038/mt.2009.222 aop current http://dx.doi.org/10.1038/mt.2009.222 A Comparison of the Growth Responses Following Intramuscular GHRH Plasmid Administration Versus Daily Growth Hormone Injections in Young Pigs http://feeds.nature.com/~r/mt/rss/aop/~3/O0VSgonjhPE/mt.2009.224 A Comparison of the Growth Responses Following Intramuscular GHRH Plasmid Administration Versus Daily Growth Hormone Injections in Young Pigs

Molecular Therapy advance online publication, October 6, 2009. doi:10.1038/mt.2009.224

Authors: Amir S Khan, Ruxandra Draghia-Akli, Roman J Shypailo, Kenneth I Ellis, Harry Mersmann & Marta L Fiorotto

]]> A Comparison of the Growth Responses Following Intramuscular GHRH Plasmid Administration Versus Daily Growth Hormone Injections in Young Pigs Amir S Khan Ruxandra Draghia-Akli Roman J Shypailo Kenneth I Ellis Harry Mersmann Marta L Fiorotto doi:10.1038/mt.2009.224 Molecular Therapy advance online publication, October 6, 2009 2009-10-06 Molecular Therapy October 6, 2009 10.1038/mt.2009.224 http://dx.doi.org/10.1038/mt.2009.224 aop current http://dx.doi.org/10.1038/mt.2009.224 Combinatorial Control of Suicide Gene Expression by Tissue-specific Promoter and microRNA Regulation for Cancer Therapy http://feeds.nature.com/~r/mt/rss/aop/~3/6sd7vzLYrKw/mt.2009.225 Combinatorial Control of Suicide Gene Expression by Tissue-specific Promoter and microRNA Regulation for Cancer Therapy

Molecular Therapy advance online publication, October 6, 2009. doi:10.1038/mt.2009.225

Authors: Chunxiao Wu, Jiakai Lin, Michelle Hong, Yukti Choudhury, Poonam Balani, Doreen Leung, Lam H Dang, Ying Zhao, Jieming Zeng & Shu Wang

]]> Combinatorial Control of Suicide Gene Expression by Tissue-specific Promoter and microRNA Regulation for Cancer Therapy Chunxiao Wu Jiakai Lin Michelle Hong Yukti Choudhury Poonam Balani Doreen Leung Lam H Dang Ying Zhao Jieming Zeng Shu Wang doi:10.1038/mt.2009.225 Molecular Therapy advance online publication, October 6, 2009 2009-10-06 Molecular Therapy October 6, 2009 10.1038/mt.2009.225 http://dx.doi.org/10.1038/mt.2009.225 aop current http://dx.doi.org/10.1038/mt.2009.225 Amphiregulin Promotes BAX Inhibition and Resistance to Gefitinib in Non-small-cell Lung Cancers http://feeds.nature.com/~r/mt/rss/aop/~3/88bcGc6vCmI/mt.2009.226 Amphiregulin Promotes BAX Inhibition and Resistance to Gefitinib in Non-small-cell Lung Cancers

Molecular Therapy advance online publication, October 13, 2009. doi:10.1038/mt.2009.226

Authors: Benoît Busser, Lucie Sancey, Véronique Josserand, Carole Niang, Marie C Favrot, Jean-Luc Coll & Amandine Hurbin

]]> Amphiregulin Promotes BAX Inhibition and Resistance to Gefitinib in Non-small-cell Lung Cancers Benoît Busser Lucie Sancey Véronique Josserand Carole Niang Marie C Favrot Jean-Luc Coll Amandine Hurbin doi:10.1038/mt.2009.226 Molecular Therapy advance online publication, October 13, 2009 2009-10-13 Molecular Therapy October 13, 2009 10.1038/mt.2009.226 http://dx.doi.org/10.1038/mt.2009.226 aop current http://dx.doi.org/10.1038/mt.2009.226 Amphiregulin Promotes Resistance to Gefitinib in NonSmall Cell Lung Cancer Cells by Regulating Ku70 Acetylation http://feeds.nature.com/~r/mt/rss/aop/~3/oaly9fJU_l4/mt.2009.227 Amphiregulin Promotes Resistance to Gefitinib in NonSmall Cell Lung Cancer Cells by Regulating Ku70 Acetylation

Molecular Therapy advance online publication, October 13, 2009. doi:10.1038/mt.2009.227

Authors: Benoît Busser, Lucie Sancey, Véronique Josserand, Carole Niang, Saadi Khochbin, Marie C Favrot, Jean-Luc Coll & Amandine Hurbin

]]> Amphiregulin Promotes Resistance to Gefitinib in NonSmall Cell Lung Cancer Cells by Regulating Ku70 Acetylation Benoît Busser Lucie Sancey Véronique Josserand Carole Niang Saadi Khochbin Marie C Favrot Jean-Luc Coll Amandine Hurbin doi:10.1038/mt.2009.227 Molecular Therapy advance online publication, October 13, 2009 2009-10-13 Molecular Therapy October 13, 2009 10.1038/mt.2009.227 http://dx.doi.org/10.1038/mt.2009.227 aop current http://dx.doi.org/10.1038/mt.2009.227 Advanced Phase I/II Studies of Targeted Gene Delivery In Vivo: Intravenous Rexin-G for Gemcitabine-resistant Metastatic Pancreatic Cancer http://feeds.nature.com/~r/mt/rss/aop/~3/k33r4T5TikA/mt.2009.228 Advanced Phase I/II Studies of Targeted Gene Delivery In Vivo: Intravenous Rexin-G for Gemcitabine-resistant Metastatic Pancreatic Cancer

Molecular Therapy advance online publication, October 13, 2009. doi:10.1038/mt.2009.228

Authors: Sant P Chawla, Victoria S Chua, Lita Fernandez, Dorris Quon, William C Blackwelder, Erlinda M Gordon & Frederick L Hall

]]> Advanced Phase I/II Studies of Targeted Gene Delivery In Vivo: Intravenous Rexin-G for Gemcitabine-resistant Metastatic Pancreatic Cancer Sant P Chawla Victoria S Chua Lita Fernandez Dorris Quon William C Blackwelder Erlinda M Gordon Frederick L Hall doi:10.1038/mt.2009.228 Molecular Therapy advance online publication, October 13, 2009 2009-10-13 Molecular Therapy October 13, 2009 10.1038/mt.2009.228 http://dx.doi.org/10.1038/mt.2009.228 aop current http://dx.doi.org/10.1038/mt.2009.228 Overexpression of Sonic Hedgehog in the Lung Mimics the Effect of Lung Injury and Compensatory Lung Growth on Pulmonary Sca-1 and CD34 Positive Cells http://feeds.nature.com/~r/mt/rss/aop/~3/dCzmjivfuW0/mt.2009.229 Overexpression of Sonic Hedgehog in the Lung Mimics the Effect of Lung Injury and Compensatory Lung Growth on Pulmonary Sca-1 and CD34 Positive Cells

Molecular Therapy advance online publication, October 27, 2009. doi:10.1038/mt.2009.229

Authors: Anja Krause, Yaqin Xu, Ju Joh, Ralf Hubner, Austen Gess, Thomas Ilic & Stefan Worgall

]]> Overexpression of Sonic Hedgehog in the Lung Mimics the Effect of Lung Injury and Compensatory Lung Growth on Pulmonary Sca-1 and CD34 Positive Cells Anja Krause Yaqin Xu Ju Joh Ralf Hubner Austen Gess Thomas Ilic Stefan Worgall doi:10.1038/mt.2009.229 Molecular Therapy advance online publication, October 27, 2009 2009-10-27 Molecular Therapy October 27, 2009 10.1038/mt.2009.229 http://dx.doi.org/10.1038/mt.2009.229 aop current http://dx.doi.org/10.1038/mt.2009.229 Dual Reporter Comparative Indexing of rAAV Pseudotyped Vectors in Chimpanzee Airway http://feeds.nature.com/~r/mt/rss/aop/~3/-iJrdMxlcVg/mt.2009.230 Dual Reporter Comparative Indexing of rAAV Pseudotyped Vectors in Chimpanzee Airway

Molecular Therapy advance online publication, October 13, 2009. doi:10.1038/mt.2009.230

Authors: Terence R Flotte, Anne C Fischer, Jason Goetzmann, Christian Mueller, Liudmila Cebotaru, Ziying Yan, Lilli Wang, James M Wilson, William B Guggino & John F Engelhardt

]]> Dual Reporter Comparative Indexing of rAAV Pseudotyped Vectors in Chimpanzee Airway Terence R Flotte Anne C Fischer Jason Goetzmann Christian Mueller Liudmila Cebotaru Ziying Yan Lilli Wang James M Wilson William B Guggino John F Engelhardt doi:10.1038/mt.2009.230 Molecular Therapy advance online publication, October 13, 2009 2009-10-13 Molecular Therapy October 13, 2009 10.1038/mt.2009.230 http://dx.doi.org/10.1038/mt.2009.230 aop current http://dx.doi.org/10.1038/mt.2009.230 Engineered Newcastle Disease Virus as an Improved Oncolytic Agent Against Hepatocellular Carcinoma http://feeds.nature.com/~r/mt/rss/aop/~3/5LbqkEU8PK4/mt.2009.231 Engineered Newcastle Disease Virus as an Improved Oncolytic Agent Against Hepatocellular Carcinoma

Molecular Therapy advance online publication, October 6, 2009. doi:10.1038/mt.2009.231

Authors: Jennifer Altomonte, Sabrina Marozin, Roland M Schmid & Oliver Ebert

]]> Engineered Newcastle Disease Virus as an Improved Oncolytic Agent Against Hepatocellular Carcinoma Jennifer Altomonte Sabrina Marozin Roland M Schmid Oliver Ebert doi:10.1038/mt.2009.231 Molecular Therapy advance online publication, October 6, 2009 2009-10-06 Molecular Therapy October 6, 2009 10.1038/mt.2009.231 http://dx.doi.org/10.1038/mt.2009.231 aop current http://dx.doi.org/10.1038/mt.2009.231 Enhanced Antitumor Efficacy of Vasculostatin (Vstat120) Expressing Oncolytic HSV-1 http://feeds.nature.com/~r/mt/rss/aop/~3/kmQZe9K5A40/mt.2009.232 Enhanced Antitumor Efficacy of Vasculostatin (Vstat120) Expressing Oncolytic HSV-1

Molecular Therapy advance online publication, October 20, 2009. doi:10.1038/mt.2009.232

Authors: Jayson Hardcastle, Kazuhiko Kurozumi, Nina Dmitrieva, Martin P Sayers, Sarwat Ahmad, Peter Waterman, Ralph Weissleder, E Antonio Chiocca & Balveen Kaur

]]> Enhanced Antitumor Efficacy of Vasculostatin (Vstat120) Expressing Oncolytic HSV-1 Jayson Hardcastle Kazuhiko Kurozumi Nina Dmitrieva Martin P Sayers Sarwat Ahmad Peter Waterman Ralph Weissleder E Antonio Chiocca Balveen Kaur doi:10.1038/mt.2009.232 Molecular Therapy advance online publication, October 20, 2009 2009-10-20 Molecular Therapy October 20, 2009 10.1038/mt.2009.232 http://dx.doi.org/10.1038/mt.2009.232 aop current http://dx.doi.org/10.1038/mt.2009.232 Gene Therapy of Mpl Deficiency: Challenging Balance Between Leukemia and Pancytopenia http://feeds.nature.com/~r/mt/rss/aop/~3/xaEVFaQi3UA/mt.2009.233 Gene Therapy of Mpl Deficiency: Challenging Balance Between Leukemia and Pancytopenia

Molecular Therapy advance online publication, October 20, 2009. doi:10.1038/mt.2009.233

Authors: Daniel C Wicke, Johann Meyer, Guntram Buesche, Dirk Heckl, Hans Kreipe, Zhixiong Li, Karl H Welte, Matthias Ballmaier, Christopher Baum & Ute Modlich

]]> Gene Therapy of Mpl Deficiency: Challenging Balance Between Leukemia and Pancytopenia Daniel C Wicke Johann Meyer Guntram Buesche Dirk Heckl Hans Kreipe Zhixiong Li Karl H Welte Matthias Ballmaier Christopher Baum Ute Modlich doi:10.1038/mt.2009.233 Molecular Therapy advance online publication, October 20, 2009 2009-10-20 Molecular Therapy October 20, 2009 10.1038/mt.2009.233 http://dx.doi.org/10.1038/mt.2009.233 aop current http://dx.doi.org/10.1038/mt.2009.233 PiggyBac Transposon-based Inducible Gene Expression In Vivo After Somatic Cell Gene Transfer http://feeds.nature.com/~r/mt/rss/aop/~3/xi_AOzNzOKE/mt.2009.234 PiggyBac Transposon-based Inducible Gene Expression In Vivo After Somatic Cell Gene Transfer

Molecular Therapy advance online publication, October 6, 2009. doi:10.1038/mt.2009.234

Authors: Sai K Saridey, Li Liu, Joseph E Doherty, Aparna Kaja, Daniel L Galvan, Bradley S Fletcher & Matthew H Wilson

]]> PiggyBac Transposon-based Inducible Gene Expression In Vivo After Somatic Cell Gene Transfer Sai K Saridey Li Liu Joseph E Doherty Aparna Kaja Daniel L Galvan Bradley S Fletcher Matthew H Wilson doi:10.1038/mt.2009.234 Molecular Therapy advance online publication, October 6, 2009 2009-10-06 Molecular Therapy October 6, 2009 10.1038/mt.2009.234 http://dx.doi.org/10.1038/mt.2009.234 aop current http://dx.doi.org/10.1038/mt.2009.234 Polysialic Acid Glycomimetic Promotes Functional Recovery and Plasticity After Spinal Cord Injury in Mice http://feeds.nature.com/~r/mt/rss/aop/~3/uZ6QeAS21vI/mt.2009.235 Polysialic Acid Glycomimetic Promotes Functional Recovery and Plasticity After Spinal Cord Injury in Mice

Molecular Therapy advance online publication, October 13, 2009. doi:10.1038/mt.2009.235

Authors: Ali Mehanna, Igor Jakovcevski, Ayşe Acar, Meifang Xiao, Gabriele Loers, Geneviève Rougon, Andrey Irintchev & Melitta Schachner

]]> Polysialic Acid Glycomimetic Promotes Functional Recovery and Plasticity After Spinal Cord Injury in Mice Ali Mehanna Igor Jakovcevski Ayşe Acar Meifang Xiao Gabriele Loers Geneviève Rougon Andrey Irintchev Melitta Schachner doi:10.1038/mt.2009.235 Molecular Therapy advance online publication, October 13, 2009 2009-10-13 Molecular Therapy October 13, 2009 10.1038/mt.2009.235 http://dx.doi.org/10.1038/mt.2009.235 aop current http://dx.doi.org/10.1038/mt.2009.235 A Self-inactivating γ-Retroviral Vector Reduces Manifestations of Mucopolysaccharidosis I in Mice http://feeds.nature.com/~r/mt/rss/aop/~3/OiGS9tv1qzk/mt.2009.236 A Self-inactivating γ-Retroviral Vector Reduces Manifestations of Mucopolysaccharidosis I in Mice

Molecular Therapy advance online publication, October 20, 2009. doi:10.1038/mt.2009.236

Authors: Jason A Metcalf, Xiucui Ma, Bruce Linders, Susan Wu, Axel Schambach, Kevin K Ohlemiller, Attila Kovacs, Mark Bigg, Li He, Douglas M Tollefsen & Katherine P Ponder

]]> A Self-inactivating γ-Retroviral Vector Reduces Manifestations of Mucopolysaccharidosis I in Mice Jason A Metcalf Xiucui Ma Bruce Linders Susan Wu Axel Schambach Kevin K Ohlemiller Attila Kovacs Mark Bigg Li He Douglas M Tollefsen Katherine P Ponder doi:10.1038/mt.2009.236 Molecular Therapy advance online publication, October 20, 2009 2009-10-20 Molecular Therapy October 20, 2009 10.1038/mt.2009.236 http://dx.doi.org/10.1038/mt.2009.236 aop current http://dx.doi.org/10.1038/mt.2009.236 Adipose Tissue–derived Mesenchymal Stem Cells Expressing Prodrug-converting Enzyme Inhibit Human Prostate Tumor Growth http://feeds.nature.com/~r/mt/rss/aop/~3/7iqxnkKSpn4/mt.2009.237 Adipose Tissue–derived Mesenchymal Stem Cells Expressing Prodrug-converting Enzyme Inhibit Human Prostate Tumor Growth

Molecular Therapy advance online publication, October 20, 2009. doi:10.1038/mt.2009.237

Authors: Ilaria T Cavarretta, Veronika Altanerova, Miroslava Matuskova, Lucia Kucerova, Zoran Culig & Cestmir Altaner

]]> Adipose Tissue–derived Mesenchymal Stem Cells Expressing Prodrug-converting Enzyme Inhibit Human Prostate Tumor Growth Ilaria T Cavarretta Veronika Altanerova Miroslava Matuskova Lucia Kucerova Zoran Culig Cestmir Altaner doi:10.1038/mt.2009.237 Molecular Therapy advance online publication, October 20, 2009 2009-10-20 Molecular Therapy October 20, 2009 10.1038/mt.2009.237 http://dx.doi.org/10.1038/mt.2009.237 aop current http://dx.doi.org/10.1038/mt.2009.237 Supplying Clotting Factors From Hematopoietic Stem Cell–derived Erythroid and Megakaryocytic Lineage Cells http://feeds.nature.com/~r/mt/rss/aop/~3/v2Wr5cUJAlk/mt.2009.238 Supplying Clotting Factors From Hematopoietic Stem Cell–derived Erythroid and Megakaryocytic Lineage Cells

Molecular Therapy advance online publication, October 20, 2009. doi:10.1038/mt.2009.238

Authors: Michel Sadelain, Alex Chang & Leszek Lisowski

]]> Supplying Clotting Factors From Hematopoietic Stem Cell–derived Erythroid and Megakaryocytic Lineage Cells Michel Sadelain Alex Chang Leszek Lisowski doi:10.1038/mt.2009.238 Molecular Therapy advance online publication, October 20, 2009 2009-10-20 Molecular Therapy October 20, 2009 10.1038/mt.2009.238 http://dx.doi.org/10.1038/mt.2009.238 aop current http://dx.doi.org/10.1038/mt.2009.238 The Pleiotropic Effects of Natural AAV Infections on Liver-directed Gene Transfer in Macaques http://feeds.nature.com/~r/mt/rss/aop/~3/7V20d4hc6mE/mt.2009.245 The Pleiotropic Effects of Natural AAV Infections on Liver-directed Gene Transfer in Macaques

Molecular Therapy advance online publication, November 3, 2009. doi:10.1038/mt.2009.245

Authors: Lili Wang, Roberto Calcedo, Huan Wang, Peter Bell, Rebecca Grant, Luk H Vandenberghe, Julio Sanmiguel, Hiroki Morizono, Mark L Batshaw & James M Wilson

]]> The Pleiotropic Effects of Natural AAV Infections on Liver-directed Gene Transfer in Macaques Lili Wang Roberto Calcedo Huan Wang Peter Bell Rebecca Grant Luk H Vandenberghe Julio Sanmiguel Hiroki Morizono Mark L Batshaw James M Wilson doi:10.1038/mt.2009.245 Molecular Therapy advance online publication, November 3, 2009 200-11-03 Molecular Therapy November 3, 2009 10.1038/mt.2009.245 http://dx.doi.org/10.1038/mt.2009.245 aop current http://dx.doi.org/10.1038/mt.2009.245 Systematic Evaluation of AAV Vectors for Liver directed Gene Transfer in Murine Models http://feeds.nature.com/~r/mt/rss/aop/~3/K0hixuoX3eE/mt.2009.246 Systematic Evaluation of AAV Vectors for Liver directed Gene Transfer in Murine Models

Molecular Therapy advance online publication, October 27, 2009. doi:10.1038/mt.2009.246

Authors: Lili Wang, Huan Wang, Peter Bell, Robert J McCarter, Jianping He, Roberto Calcedo, Luk H Vandenberghe, Hiroki Morizono, Mark L Batshaw & James M Wilson

]]> Systematic Evaluation of AAV Vectors for Liver directed Gene Transfer in Murine Models Lili Wang Huan Wang Peter Bell Robert J McCarter Jianping He Roberto Calcedo Luk H Vandenberghe Hiroki Morizono Mark L Batshaw James M Wilson doi:10.1038/mt.2009.246 Molecular Therapy advance online publication, October 27, 2009 2009-10-27 Molecular Therapy October 27, 2009 10.1038/mt.2009.246 http://dx.doi.org/10.1038/mt.2009.246 aop current http://dx.doi.org/10.1038/mt.2009.246 Long-term Rescue of a Lethal Murine Model of Methylmalonic Acidemia Using Adeno associated Viral Gene Therapy http://feeds.nature.com/~r/mt/rss/aop/~3/JDBMfWkM1T4/mt.2009.247 Long-term Rescue of a Lethal Murine Model of Methylmalonic Acidemia Using Adeno associated Viral Gene Therapy

Molecular Therapy advance online publication, October 27, 2009. doi:10.1038/mt.2009.247

Authors: Randy J Chandler & Charles P Venditti

]]> Long-term Rescue of a Lethal Murine Model of Methylmalonic Acidemia Using Adeno associated Viral Gene Therapy Randy J Chandler Charles P Venditti doi:10.1038/mt.2009.247 Molecular Therapy advance online publication, October 27, 2009 2009-10-27 Molecular Therapy October 27, 2009 10.1038/mt.2009.247 http://dx.doi.org/10.1038/mt.2009.247 aop current http://dx.doi.org/10.1038/mt.2009.247 Prevention of Dystrophic Pathology in Severely Affected Dystrophin/Utrophin-deficient Mice by Morpholino-oligomer-mediated Exon-skipping http://feeds.nature.com/~r/mt/rss/aop/~3/dfKzohsdEAI/mt.2009.248 Prevention of Dystrophic Pathology in Severely Affected Dystrophin/Utrophin-deficient Mice by Morpholino-oligomer-mediated Exon-skipping

Molecular Therapy advance online publication, October 20, 2009. doi:10.1038/mt.2009.248

Authors: Aurélie Goyenvalle, Arran Babbs, Dave Powell, Ryszard Kole, Sue Fletcher, Steve D Wilton & Kay E Davies

]]> Prevention of Dystrophic Pathology in Severely Affected Dystrophin/Utrophin-deficient Mice by Morpholino-oligomer-mediated Exon-skipping Aurélie Goyenvalle Arran Babbs Dave Powell Ryszard Kole Sue Fletcher Steve D Wilton Kay E Davies doi:10.1038/mt.2009.248 Molecular Therapy advance online publication, October 20, 2009 2009-10-20 Molecular Therapy October 20, 2009 10.1038/mt.2009.248 http://dx.doi.org/10.1038/mt.2009.248 aop current http://dx.doi.org/10.1038/mt.2009.248 Long-term Physiologically Regulated Expression of the Low-density Lipoprotein Receptor In Vivo Using Genomic DNA Mini-gene Constructs http://feeds.nature.com/~r/mt/rss/aop/~3/7zriyyp0RTw/mt.2009.249 Long-term Physiologically Regulated Expression of the Low-density Lipoprotein Receptor In Vivo Using Genomic DNA Mini-gene Constructs

Molecular Therapy advance online publication, October 27, 2009. doi:10.1038/mt.2009.249

Authors: Olivia C Hibbitt, Eileen McNeil, Michele MP Lufino, Len Seymour, Keith Channon & Richard Wade-Martins

]]> Long-term Physiologically Regulated Expression of the Low-density Lipoprotein Receptor In Vivo Using Genomic DNA Mini-gene Constructs Olivia C Hibbitt Eileen McNeil Michele MP Lufino Len Seymour Keith Channon Richard Wade-Martins doi:10.1038/mt.2009.249 Molecular Therapy advance online publication, October 27, 2009 2009-10-27 Molecular Therapy October 27, 2009 10.1038/mt.2009.249 http://dx.doi.org/10.1038/mt.2009.249 aop current http://dx.doi.org/10.1038/mt.2009.249 AAV8-mediated Gene Therapy Prevents Induced Biochemical Attacks of Acute Intermittent Porphyria and Improves Neuromotor Function http://feeds.nature.com/~r/mt/rss/aop/~3/YBucyGt20Bo/mt.2009.250 AAV8-mediated Gene Therapy Prevents Induced Biochemical Attacks of Acute Intermittent Porphyria and Improves Neuromotor Function

Molecular Therapy advance online publication, October 27, 2009. doi:10.1038/mt.2009.250

Authors: Makiko Yasuda, David F Bishop, Mary Fowkes, Seng H Cheng, Lin Gan & Robert J Desnick

]]> AAV8-mediated Gene Therapy Prevents Induced Biochemical Attacks of Acute Intermittent Porphyria and Improves Neuromotor Function Makiko Yasuda David F Bishop Mary Fowkes Seng H Cheng Lin Gan Robert J Desnick doi:10.1038/mt.2009.250 Molecular Therapy advance online publication, October 27, 2009 2009-10-27 Molecular Therapy October 27, 2009 10.1038/mt.2009.250 http://dx.doi.org/10.1038/mt.2009.250 aop current http://dx.doi.org/10.1038/mt.2009.250 Lack of Immunotoxicity After Regional Intravenous (RI) Delivery of rAAV to Nonhuman Primate Skeletal Muscle http://feeds.nature.com/~r/mt/rss/aop/~3/UIqqEPHSIFc/mt.2009.251 Lack of Immunotoxicity After Regional Intravenous (RI) Delivery of rAAV to Nonhuman Primate Skeletal Muscle

Molecular Therapy advance online publication, November 3, 2009. doi:10.1038/mt.2009.251

Authors: Alice Toromanoff, Oumeya Adjali, Thibaut Larcher, Marcelo Hill, Lydie Guigand, Pierre Chenuaud, Jack-Yves Deschamps, Olivier Gauthier, Gilles Blancho, Bernard Vanhove, Fabienne Rolling, Yan Chérel, Philippe Moullier, Ignacio Anegon & Caroline Le Guiner

]]> Lack of Immunotoxicity After Regional Intravenous (RI) Delivery of rAAV to Nonhuman Primate Skeletal Muscle Alice Toromanoff Oumeya Adjali Thibaut Larcher Marcelo Hill Lydie Guigand Pierre Chenuaud Jack-Yves Deschamps Olivier Gauthier Gilles Blancho Bernard Vanhove Fabienne Rolling Yan Chérel Philippe Moullier Ignacio Anegon Caroline Le Guiner doi:10.1038/mt.2009.251 Molecular Therapy advance online publication, November 3, 2009 200-11-03 Molecular Therapy November 3, 2009 10.1038/mt.2009.251 http://dx.doi.org/10.1038/mt.2009.251 aop current http://dx.doi.org/10.1038/mt.2009.251 Eradication of Therapy-resistant Human Prostate Tumors Using an Ultrasound-guided Site-specific Cancer Terminator Virus Delivery Approach http://feeds.nature.com/~r/mt/rss/aop/~3/i47MrdT86wA/mt.2009.252 Eradication of Therapy-resistant Human Prostate Tumors Using an Ultrasound-guided Site-specific Cancer Terminator Virus Delivery Approach

Molecular Therapy advance online publication, November 3, 2009. doi:10.1038/mt.2009.252

Authors: Adelaide Greco, Altomare Di Benedetto, Candace M Howard, Sarah Kelly, Rounak Nande, Yulia Dementieva, Michele Miranda, Arturo Brunetti, Marco Salvatore, Luigi Claudio, Devanand Sarkar, Paul Dent, David T Curiel, Paul B Fisher & Pier P Claudio

]]> Eradication of Therapy-resistant Human Prostate Tumors Using an Ultrasound-guided Site-specific Cancer Terminator Virus Delivery Approach Adelaide Greco Altomare Di Benedetto Candace M Howard Sarah Kelly Rounak Nande Yulia Dementieva Michele Miranda Arturo Brunetti Marco Salvatore Luigi Claudio Devanand Sarkar Paul Dent David T Curiel Paul B Fisher Pier P Claudio doi:10.1038/mt.2009.252 Molecular Therapy advance online publication, November 3, 2009 200-11-03 Molecular Therapy November 3, 2009 10.1038/mt.2009.252 http://dx.doi.org/10.1038/mt.2009.252 aop current http://dx.doi.org/10.1038/mt.2009.252 Dystrophin Delivery to Muscles of mdx Mice Using Lentiviral Vectors Leads to Myogenic Progenitor Targeting and Stable Gene Expression http://feeds.nature.com/~r/mt/rss/aop/~3/QdPHdRGIClY/mt.2009.253 Dystrophin Delivery to Muscles of mdx Mice Using Lentiviral Vectors Leads to Myogenic Progenitor Targeting and Stable Gene Expression

Molecular Therapy advance online publication, November 3, 2009. doi:10.1038/mt.2009.253

Authors: En Kimura, Sheng Li, Paul Gregorevic, Brent M Fall & Jeffrey S Chamberlain

]]> Dystrophin Delivery to Muscles of mdx Mice Using Lentiviral Vectors Leads to Myogenic Progenitor Targeting and Stable Gene Expression En Kimura Sheng Li Paul Gregorevic Brent M Fall Jeffrey S Chamberlain doi:10.1038/mt.2009.253 Molecular Therapy advance online publication, November 3, 2009 200-11-03 Molecular Therapy November 3, 2009 10.1038/mt.2009.253 http://dx.doi.org/10.1038/mt.2009.253 aop current http://dx.doi.org/10.1038/mt.2009.253