Molecular Therapy - Issue - nature.com science feeds mt is a cross-disciplinary biomedical journal devoted to publishing the most exciting advances in pharmacology and therapeutics, as they pertain to advances in translational and clinical medicine. It is recognized as one of the most prestigious journals in the field. With an impact factor of 6.825*, mt ranks in the top 4.2% of scientific journals in the latest Science Citation Index. Published monthly online and in print. http://www.nature.com/mt/current_issue/ Nature Publishing Group en Copyright © Nature Publishing Group Molecular Therapy 1525-0016 Copyright © Nature Publishing Group permissions@nature.com Molecular Therapy http://www.nature.com/aj/images/logos_b_o_w/mt.gif http://www.nature.com/mt/ Risk in Clinical Research: Size Matters! http://feeds.nature.com/~r/mt/rss/current/~3/kkEfqUfEXUA/mt.2009.242 Risk in Clinical Research: Size Matters!

Molecular Therapy 17, 1833 (November 2009). doi:10.1038/mt.2009.242

Author: Pedro R Lowenstein

]]> Risk in Clinical Research: Size Matters! Pedro R Lowenstein doi:10.1038/mt.2009.242 Molecular Therapy 17, 1833 (November 2009) 2009-10-30 Molecular Therapy 10.1038/mt.2009.242 http://dx.doi.org/10.1038/mt.2009.242 17 11 1833 1834 http://dx.doi.org/10.1038/mt.2009.242 In This Issue http://feeds.nature.com/~r/mt/rss/current/~3/AhC0Oa4n27Y/mt.2009.243 In This Issue

Molecular Therapy 17, 1836 (November 2009). doi:10.1038/mt.2009.243

]]> In This Issue doi:10.1038/mt.2009.243 Molecular Therapy 17, 1836 (November 2009) 2009-10-30 Molecular Therapy 10.1038/mt.2009.243 http://dx.doi.org/10.1038/mt.2009.243 17 11 1836 1836 http://dx.doi.org/10.1038/mt.2009.243 Research Highlights http://feeds.nature.com/~r/mt/rss/current/~3/LAA3pCdcf2U/mt.2009.244 Research Highlights

Molecular Therapy 17, 1837 (November 2009). doi:10.1038/mt.2009.244

]]> Research Highlights doi:10.1038/mt.2009.244 Molecular Therapy 17, 1837 (November 2009) 2009-10-30 Molecular Therapy 10.1038/mt.2009.244 http://dx.doi.org/10.1038/mt.2009.244 17 11 1837 1837 http://dx.doi.org/10.1038/mt.2009.244 Tomorrow, Interrupted?: Risk, Ethics, and Medical Advance in Gene Transfer http://feeds.nature.com/~r/mt/rss/current/~3/tQYL12V1gQA/mt.2009.240 Tomorrow, Interrupted?: Risk, Ethics, and Medical Advance in Gene Transfer

Molecular Therapy 17, 1838 (November 2009). doi:10.1038/mt.2009.240

Author: Jonathan Kimmelman

]]> Tomorrow, Interrupted?: Risk, Ethics, and Medical Advance in Gene Transfer Jonathan Kimmelman doi:10.1038/mt.2009.240 Molecular Therapy 17, 1838 (November 2009) 2009-10-30 Molecular Therapy 10.1038/mt.2009.240 http://dx.doi.org/10.1038/mt.2009.240 17 11 1838 1839 http://dx.doi.org/10.1038/mt.2009.240 Autophagy Links Pattern Recognition Receptors to Tumor Cell Apoptosis http://feeds.nature.com/~r/mt/rss/current/~3/ZYtluLW6OoM/mt.2009.241 Autophagy Links Pattern Recognition Receptors to Tumor Cell Apoptosis

Molecular Therapy 17, 1839 (November 2009). doi:10.1038/mt.2009.241

Author: Jörg Vollmer

]]> Autophagy Links Pattern Recognition Receptors to Tumor Cell Apoptosis Jörg Vollmer doi:10.1038/mt.2009.241 Molecular Therapy 17, 1839 (November 2009) 2009-10-30 Molecular Therapy 10.1038/mt.2009.241 http://dx.doi.org/10.1038/mt.2009.241 17 11 1839 1841 http://dx.doi.org/10.1038/mt.2009.241 Accepting Risk in Clinical Research: Is the Gene Therapy Field Becoming Too Risk-averse? http://feeds.nature.com/~r/mt/rss/current/~3/rXGHNnIli4Y/mt.2009.223 Accepting Risk in Clinical Research: Is the Gene Therapy Field Becoming Too Risk-averse?

Molecular Therapy 17, 1842 (November 2009). doi:10.1038/mt.2009.223

Authors: Claire T Deakin, Ian E Alexander & Ian Kerridge

]]> Accepting Risk in Clinical Research: Is the Gene Therapy Field Becoming Too Risk-averse? Claire T Deakin Ian E Alexander Ian Kerridge doi:10.1038/mt.2009.223 Molecular Therapy 17, 1842 (November 2009) 2009-10-30 Molecular Therapy September 22, 2009 10.1038/mt.2009.223 http://dx.doi.org/10.1038/mt.2009.223 17 11 1842 1848 http://dx.doi.org/10.1038/mt.2009.223 Drug Nanocarriers Labeled With Near-infrared-emitting Quantum Dots (Quantoplexes): Imaging Fast Dynamics of Distribution in Living Animals http://feeds.nature.com/~r/mt/rss/current/~3/EzkNFXMr5_o/mt.2009.201 Drug Nanocarriers Labeled With Near-infrared-emitting Quantum Dots (Quantoplexes): Imaging Fast Dynamics of Distribution in Living Animals

Molecular Therapy 17, 1849 (November 2009). doi:10.1038/mt.2009.201

Authors: Arkadi Zintchenko, Andrei S Susha, Massimo Concia, Jochen Feldmann, Ernst Wagner, Andrey L Rogach & Manfred Ogris

]]> Drug Nanocarriers Labeled With Near-infrared-emitting Quantum Dots (Quantoplexes): Imaging Fast Dynamics of Distribution in Living Animals Arkadi Zintchenko Andrei S Susha Massimo Concia Jochen Feldmann Ernst Wagner Andrey L Rogach Manfred Ogris doi:10.1038/mt.2009.201 Molecular Therapy 17, 1849 (November 2009) 2009-10-30 Molecular Therapy August 25, 2009 10.1038/mt.2009.201 http://dx.doi.org/10.1038/mt.2009.201 17 11 1849 1856 http://dx.doi.org/10.1038/mt.2009.201 Tight Long-term Dynamic Doxycycline Responsive Nigrostriatal GDNF Using a Single rAAV Vector http://feeds.nature.com/~r/mt/rss/current/~3/0VePjsmfmsU/mt.2009.196 Tight Long-term Dynamic Doxycycline Responsive Nigrostriatal GDNF Using a Single rAAV Vector

Molecular Therapy 17, 1857 (November 2009). doi:10.1038/mt.2009.196

Authors: Fredric P Manfredsson, Corinna Burger, Aaron C Rising, Kheir Zuobi-Hasona, Layla F Sullivan, Alfred S Lewin, Julia Huang, Emily Piercefield, Nicholas Muzyczka & Ronald J Mandel

]]> Tight Long-term Dynamic Doxycycline Responsive Nigrostriatal GDNF Using a Single rAAV Vector Fredric P Manfredsson Corinna Burger Aaron C Rising Kheir Zuobi-Hasona Layla F Sullivan Alfred S Lewin Julia Huang Emily Piercefield Nicholas Muzyczka Ronald J Mandel doi:10.1038/mt.2009.196 Molecular Therapy 17, 1857 (November 2009) 2009-10-30 Molecular Therapy August 25, 2009 10.1038/mt.2009.196 http://dx.doi.org/10.1038/mt.2009.196 17 11 1857 1867 http://dx.doi.org/10.1038/mt.2009.196 Cell-surface Accumulation of Flock House Virus-derived Peptide Leads to Efficient Internalization via Macropinocytosis http://feeds.nature.com/~r/mt/rss/current/~3/mwr7UfasOu8/mt.2009.192 Cell-surface Accumulation of Flock House Virus-derived Peptide Leads to Efficient Internalization via Macropinocytosis

Molecular Therapy 17, 1868 (November 2009). doi:10.1038/mt.2009.192

Authors: Ikuhiko Nakase, Hisaaki Hirose, Gen Tanaka, Akiko Tadokoro, Sachiko Kobayashi, Toshihide Takeuchi & Shiroh Futaki

]]> Cell-surface Accumulation of Flock House Virus-derived Peptide Leads to Efficient Internalization via Macropinocytosis Ikuhiko Nakase Hisaaki Hirose Gen Tanaka Akiko Tadokoro Sachiko Kobayashi Toshihide Takeuchi Shiroh Futaki doi:10.1038/mt.2009.192 Molecular Therapy 17, 1868 (November 2009) 2009-10-30 Molecular Therapy August 25, 2009 10.1038/mt.2009.192 http://dx.doi.org/10.1038/mt.2009.192 17 11 1868 1876 http://dx.doi.org/10.1038/mt.2009.192 Computational Design and Application of Endogenous Promoters for Transcriptionally Targeted Gene Therapy for Rheumatoid Arthritis http://feeds.nature.com/~r/mt/rss/current/~3/fYey6W8wNr4/mt.2009.182 Computational Design and Application of Endogenous Promoters for Transcriptionally Targeted Gene Therapy for Rheumatoid Arthritis

Molecular Therapy 17, 1877 (November 2009). doi:10.1038/mt.2009.182

Authors: Jeroen Geurts, Leo AB Joosten, Nozomi Takahashi, Onno J Arntz, Anton Glück, Miranda B Bennink, Wim B van den Berg & Fons AJ van de Loo

]]> Computational Design and Application of Endogenous Promoters for Transcriptionally Targeted Gene Therapy for Rheumatoid Arthritis Jeroen Geurts Leo AB Joosten Nozomi Takahashi Onno J Arntz Anton Glück Miranda B Bennink Wim B van den Berg Fons AJ van de Loo doi:10.1038/mt.2009.182 Molecular Therapy 17, 1877 (November 2009) 2009-10-30 Molecular Therapy August 18, 2009 10.1038/mt.2009.182 http://dx.doi.org/10.1038/mt.2009.182 17 11 1877 1887 http://dx.doi.org/10.1038/mt.2009.182 A Simplified Baculovirus-AAV Expression Vector System Coupled With One-step Affinity Purification Yields High-titer rAAV Stocks From Insect Cells http://feeds.nature.com/~r/mt/rss/current/~3/ND8pbpRs_Ko/mt.2009.128 A Simplified Baculovirus-AAV Expression Vector System Coupled With One-step Affinity Purification Yields High-titer rAAV Stocks From Insect Cells

Molecular Therapy 17, 1888 (November 2009). doi:10.1038/mt.2009.128

Authors: Richard H Smith, Justin R Levy & Robert M Kotin

]]> A Simplified Baculovirus-AAV Expression Vector System Coupled With One-step Affinity Purification Yields High-titer rAAV Stocks From Insect Cells Richard H Smith Justin R Levy Robert M Kotin doi:10.1038/mt.2009.128 Molecular Therapy 17, 1888 (November 2009) 2009-10-30 Molecular Therapy June 16, 2009 10.1038/mt.2009.128 http://dx.doi.org/10.1038/mt.2009.128 17 11 1888 1896 http://dx.doi.org/10.1038/mt.2009.128 Identification of Protein Cofactors Necessary for Sequence-specific Plasmid DNA Nuclear Import http://feeds.nature.com/~r/mt/rss/current/~3/8xKziSuJ2vE/mt.2009.127 Identification of Protein Cofactors Necessary for Sequence-specific Plasmid DNA Nuclear Import

Molecular Therapy 17, 1897 (November 2009). doi:10.1038/mt.2009.127

Authors: Aaron M Miller, Felix M Munkonge, Eric WFW Alton & David A Dean

]]> Identification of Protein Cofactors Necessary for Sequence-specific Plasmid DNA Nuclear Import Aaron M Miller Felix M Munkonge Eric WFW Alton David A Dean doi:10.1038/mt.2009.127 Molecular Therapy 17, 1897 (November 2009) 2009-10-30 Molecular Therapy June 16, 2009 10.1038/mt.2009.127 http://dx.doi.org/10.1038/mt.2009.127 17 11 1897 1903 http://dx.doi.org/10.1038/mt.2009.127 Transgene Expression Levels Determine the Immunogenicity of Transduced Hematopoietic Grafts in Partially Myeloablated Mice http://feeds.nature.com/~r/mt/rss/current/~3/-gSBLiy9SiA/mt.2009.198 Transgene Expression Levels Determine the Immunogenicity of Transduced Hematopoietic Grafts in Partially Myeloablated Mice

Molecular Therapy 17, 1904 (November 2009). doi:10.1038/mt.2009.198

Authors: Herena Eixarch, Alba Gómez, Elisabeth Kádár, Mónica George, Nuria Martínez, Carmen Espejo, Jordi Pétriz, Ramon Gimeno & Jordi Barquinero

]]> Transgene Expression Levels Determine the Immunogenicity of Transduced Hematopoietic Grafts in Partially Myeloablated Mice Herena Eixarch Alba Gómez Elisabeth Kádár Mónica George Nuria Martínez Carmen Espejo Jordi Pétriz Ramon Gimeno Jordi Barquinero doi:10.1038/mt.2009.198 Molecular Therapy 17, 1904 (November 2009) 2009-10-30 Molecular Therapy August 25, 2009 10.1038/mt.2009.198 http://dx.doi.org/10.1038/mt.2009.198 17 11 1904 1909 http://dx.doi.org/10.1038/mt.2009.198 Self-inactivating Retroviral Vector-mediated Gene Transfer Induces Oncogene Activation and Immortalization of Primary Murine Bone Marrow Cells http://feeds.nature.com/~r/mt/rss/current/~3/de9qsEBHZ64/mt.2009.172 Self-inactivating Retroviral Vector-mediated Gene Transfer Induces Oncogene Activation and Immortalization of Primary Murine Bone Marrow Cells

Molecular Therapy 17, 1910 (November 2009). doi:10.1038/mt.2009.172

Authors: Marita Bosticardo, Amrita Ghosh, Yang Du, Nancy A Jenkins, Neal G Copeland & Fabio Candotti

]]> Self-inactivating Retroviral Vector-mediated Gene Transfer Induces Oncogene Activation and Immortalization of Primary Murine Bone Marrow Cells Marita Bosticardo Amrita Ghosh Yang Du Nancy A Jenkins Neal G Copeland Fabio Candotti doi:10.1038/mt.2009.172 Molecular Therapy 17, 1910 (November 2009) 2009-10-30 Molecular Therapy July 28, 2009 10.1038/mt.2009.172 http://dx.doi.org/10.1038/mt.2009.172 17 11 1910 1918 http://dx.doi.org/10.1038/mt.2009.172 Insertional Transformation of Hematopoietic Cells by Self-inactivating Lentiviral and Gammaretroviral Vectors http://feeds.nature.com/~r/mt/rss/current/~3/5IdeK2gD0YM/mt.2009.179 Insertional Transformation of Hematopoietic Cells by Self-inactivating Lentiviral and Gammaretroviral Vectors

Molecular Therapy 17, 1919 (November 2009). doi:10.1038/mt.2009.179

Authors: Ute Modlich, Susana Navarro, Daniela Zychlinski, Tobias Maetzig, Sabine Knoess, Martijn H. Brugman, Axel Schambach, Sabine Charrier, Anne Galy, Adrian J. Thrasher, Juan Bueren & Christopher Baum

]]> Insertional Transformation of Hematopoietic Cells by Self-inactivating Lentiviral and Gammaretroviral Vectors Ute Modlich Susana Navarro Daniela Zychlinski Tobias Maetzig Sabine Knoess Martijn H. Brugman Axel Schambach Sabine Charrier Anne Galy Adrian J. Thrasher Juan Bueren Christopher Baum doi:10.1038/mt.2009.179 Molecular Therapy 17, 1919 (November 2009) 2009-10-30 Molecular Therapy August 11, 2009 10.1038/mt.2009.179 http://dx.doi.org/10.1038/mt.2009.179 17 11 1919 1928 http://dx.doi.org/10.1038/mt.2009.179 Genotoxic Potential of Lineage-specific Lentivirus Vectors Carrying the β-Globin Locus Control Region http://feeds.nature.com/~r/mt/rss/current/~3/0gx99kd3J-k/mt.2009.183 Genotoxic Potential of Lineage-specific Lentivirus Vectors Carrying the β-Globin Locus Control Region

Molecular Therapy 17, 1929 (November 2009). doi:10.1038/mt.2009.183

Authors: Paritha I Arumugam, Tomoyasu Higashimoto, Fabrizia Urbinati, Ute Modlich, Shawna Nestheide, Ping Xia, Catherine Fox, Andrea Corsinotti, Christopher Baum & Punam Malik

]]> Genotoxic Potential of Lineage-specific Lentivirus Vectors Carrying the β-Globin Locus Control Region Paritha I Arumugam Tomoyasu Higashimoto Fabrizia Urbinati Ute Modlich Shawna Nestheide Ping Xia Catherine Fox Andrea Corsinotti Christopher Baum Punam Malik doi:10.1038/mt.2009.183 Molecular Therapy 17, 1929 (November 2009) 2009-10-30 Molecular Therapy August 25, 2009 10.1038/mt.2009.183 http://dx.doi.org/10.1038/mt.2009.183 17 11 1929 1937 http://dx.doi.org/10.1038/mt.2009.183 CD133 Identifies a Human Bone Marrow Stem/Progenitor Cell Sub-population With a Repertoire of Secreted Factors That Protect Against Stroke http://feeds.nature.com/~r/mt/rss/current/~3/0YEIHBTeB-c/mt.2009.185 CD133 Identifies a Human Bone Marrow Stem/Progenitor Cell Sub-population With a Repertoire of Secreted Factors That Protect Against Stroke

Molecular Therapy 17, 1938 (November 2009). doi:10.1038/mt.2009.185

Authors: Benjamin Bakondi, Issei S Shimada, Anthony Perry, James R Munoz, Joni Ylostalo, Alan B Howard, Carl A Gregory & Jeffrey L Spees

]]> CD133 Identifies a Human Bone Marrow Stem/Progenitor Cell Sub-population With a Repertoire of Secreted Factors That Protect Against Stroke Benjamin Bakondi Issei S Shimada Anthony Perry James R Munoz Joni Ylostalo Alan B Howard Carl A Gregory Jeffrey L Spees doi:10.1038/mt.2009.185 Molecular Therapy 17, 1938 (November 2009) 2009-10-30 Molecular Therapy August 18, 2009 10.1038/mt.2009.185 http://dx.doi.org/10.1038/mt.2009.185 17 11 1938 1947 http://dx.doi.org/10.1038/mt.2009.185 Aldehyde Dehydrogenase Activity Identifies a Population of Human Skeletal Muscle Cells With High Myogenic Capacities http://feeds.nature.com/~r/mt/rss/current/~3/rnCVFzZhXug/mt.2009.204 Aldehyde Dehydrogenase Activity Identifies a Population of Human Skeletal Muscle Cells With High Myogenic Capacities

Molecular Therapy 17, 1948 (November 2009). doi:10.1038/mt.2009.204

Authors: Karine Vauchez, Jean-Pierre Marolleau, Michel Schmid, Patricia Khattar, Alain Chapel, Cyril Catelain, Séverine Lecourt, Jérôme Larghéro, Marc Fiszman & Jean-Thomas Vilquin

]]> Aldehyde Dehydrogenase Activity Identifies a Population of Human Skeletal Muscle Cells With High Myogenic Capacities Karine Vauchez Jean-Pierre Marolleau Michel Schmid Patricia Khattar Alain Chapel Cyril Catelain Séverine Lecourt Jérôme Larghéro Marc Fiszman Jean-Thomas Vilquin doi:10.1038/mt.2009.204 Molecular Therapy 17, 1948 (November 2009) 2009-10-30 Molecular Therapy September 8, 2009 10.1038/mt.2009.204 http://dx.doi.org/10.1038/mt.2009.204 17 11 1948 1958 http://dx.doi.org/10.1038/mt.2009.204 Mesenchymal Stem Cells Arrest Intervertebral Disc Degeneration Through Chondrocytic Differentiation and Stimulation of Endogenous Cells http://feeds.nature.com/~r/mt/rss/current/~3/KIyTP1G6Gq4/mt.2009.146 Mesenchymal Stem Cells Arrest Intervertebral Disc Degeneration Through Chondrocytic Differentiation and Stimulation of Endogenous Cells

Molecular Therapy 17, 1959 (November 2009). doi:10.1038/mt.2009.146

Authors: Fan Yang, Victor YL Leung, Keith DK Luk, Danny Chan & Kenneth MC Cheung

]]> Mesenchymal Stem Cells Arrest Intervertebral Disc Degeneration Through Chondrocytic Differentiation and Stimulation of Endogenous Cells Fan Yang Victor YL Leung Keith DK Luk Danny Chan Kenneth MC Cheung doi:10.1038/mt.2009.146 Molecular Therapy 17, 1959 (November 2009) 2009-10-30 Molecular Therapy July 7, 2009 10.1038/mt.2009.146 http://dx.doi.org/10.1038/mt.2009.146 17 11 1959 1966 http://dx.doi.org/10.1038/mt.2009.146 Determination of the Fate and Contribution of Ex Vivo Expanded Human Bone Marrow Stem and Progenitor Cells for Bone Formation by 2.3ColGFP http://feeds.nature.com/~r/mt/rss/current/~3/j1-bYgUmGcM/mt.2009.151 Determination of the Fate and Contribution of Ex Vivo Expanded Human Bone Marrow Stem and Progenitor Cells for Bone Formation by 2.3ColGFP

Molecular Therapy 17, 1967 (November 2009). doi:10.1038/mt.2009.151

Authors: Dezhong Yin, Zhuo Wang, Qinghong Gao, Renuka Sundaresan, Chris Parrish, Qingfen Yang, Paul H Krebsbach, Alexander C Lichtler, David W Rowe, Janet Hock & Peng Liu

]]> Determination of the Fate and Contribution of Ex Vivo Expanded Human Bone Marrow Stem and Progenitor Cells for Bone Formation by 2.3ColGFP Dezhong Yin Zhuo Wang Qinghong Gao Renuka Sundaresan Chris Parrish Qingfen Yang Paul H Krebsbach Alexander C Lichtler David W Rowe Janet Hock Peng Liu doi:10.1038/mt.2009.151 Molecular Therapy 17, 1967 (November 2009) 2009-10-30 Molecular Therapy July 14, 2009 10.1038/mt.2009.151 http://dx.doi.org/10.1038/mt.2009.151 17 11 1967 1978 http://dx.doi.org/10.1038/mt.2009.151 Transplantation of Mesenchymal Stem Cells Overexpressing RANK-Fc or CXCR4 Prevents Bone Loss in Ovariectomized Mice http://feeds.nature.com/~r/mt/rss/current/~3/DyR70WuKMrQ/mt.2009.153 Transplantation of Mesenchymal Stem Cells Overexpressing RANK-Fc or CXCR4 Prevents Bone Loss in Ovariectomized Mice

Molecular Therapy 17, 1979 (November 2009). doi:10.1038/mt.2009.153

Authors: Sun Wook Cho, Hyun Jin Sun, Jae-Yeon Yang, Ju Yeon Jung, Jee Hyun An, Hwa Young Cho, Hyung Jin Choi, Sang Wan Kim, Seong Yeon Kim, Dohee Kim & Chan Soo Shin

]]> Transplantation of Mesenchymal Stem Cells Overexpressing RANK-Fc or CXCR4 Prevents Bone Loss in Ovariectomized Mice Sun Wook Cho Hyun Jin Sun Jae-Yeon Yang Ju Yeon Jung Jee Hyun An Hwa Young Cho Hyung Jin Choi Sang Wan Kim Seong Yeon Kim Dohee Kim Chan Soo Shin doi:10.1038/mt.2009.153 Molecular Therapy 17, 1979 (November 2009) 2009-10-30 Molecular Therapy July 14, 2009 10.1038/mt.2009.153 http://dx.doi.org/10.1038/mt.2009.153 17 11 1979 1987 http://dx.doi.org/10.1038/mt.2009.153