Nature Metabolism Nature Metabolism will publish work from across all fields of metabolism research that significantly advances our understanding of metabolic and homeostatic processes in a cellular or broader physiological context, from fundamental cell biology to basic biomedical and translational research. At its core, the research published in Nature Metabolism will shed light on how cellular metabolism informs cellular function, on the physiology and homeostasis of organs and tissues, on the regulation of organismal energy homeostasis, and on the molecular pathophysiology of metabolic diseases, such as diabetes and obesity, or the treatment thereof. http://feeds.nature.com/natmetab/rss/current Nature Publishing Group en © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Metabolism © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com Nature Metabolism https://www.nature.com/uploads/product/natmetab/rss.gif http://feeds.nature.com/natmetab/rss/current <![CDATA[Metformin induces a Lac-Phe gut–brain signalling axis]]> https://www.nature.com/articles/s42255-024-01014-x Nature Metabolism, Published online: 18 March 2024; doi:10.1038/s42255-024-01014-x

The mechanism by which metformin affects food intake remains controversial. Now, two studies link metformin treatment with the induction of the appetite-suppressing metabolite N-lactoyl-phenylalanine, which is produced by the intestine.]]>
Tara TeSlaa doi:10.1038/s42255-024-01014-x Nature Metabolism, Published online: 2024-03-18; | doi:10.1038/s42255-024-01014-x 2024-03-18 Nature Metabolism 10.1038/s42255-024-01014-x https://www.nature.com/articles/s42255-024-01014-x
<![CDATA[Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans]]> https://www.nature.com/articles/s42255-024-01018-7 Nature Metabolism, Published online: 18 March 2024; doi:10.1038/s42255-024-01018-7

Metformin treatment was found to be associated with acute increases in the appetite-suppressing metabolite Lac-Phe in several human observational and interventional studies.]]>
Barry ScottEmily A. DayKatie L. O’BrienJohn ScanlanGrace CromwellAine Ni ScannailMarie E. McDonnellDavid K. FinlayLydia Lynch doi:10.1038/s42255-024-01018-7 Nature Metabolism, Published online: 2024-03-18; | doi:10.1038/s42255-024-01018-7 2024-03-18 Nature Metabolism 10.1038/s42255-024-01018-7 https://www.nature.com/articles/s42255-024-01018-7
<![CDATA[Lac-Phe mediates the effects of metformin on food intake and body weight]]> https://www.nature.com/articles/s42255-024-00999-9 Nature Metabolism, Published online: 18 March 2024; doi:10.1038/s42255-024-00999-9

Metformin is shown to trigger production and release of Lac-Phe from gut epithelial cells, which is required for its effects on food intake and loss of body weight.]]>
Shuke XiaoVeronica L. LiXuchao LyuXudong ChenWei WeiFahim AbbasiJoshua W. KnowlesAlan Sheng-Hwa TungShuliang DengGaurav TiwariXu ShiShuning ZhengLaurie FarrellZsu-Zsu ChenKent D. TaylorXiuqing GuoMark O. GoodarziAlexis C. WoodYii-Der Ida ChenLeslie A. LangeStephen S. RichJerome I. RotterClary B. ClishUsman A. TahirRobert E. GersztenMark D. BensonJonathan Z. Long doi:10.1038/s42255-024-00999-9 Nature Metabolism, Published online: 2024-03-18; | doi:10.1038/s42255-024-00999-9 2024-03-18 Nature Metabolism 10.1038/s42255-024-00999-9 https://www.nature.com/articles/s42255-024-00999-9
<![CDATA[The pressure not to eat]]> https://www.nature.com/articles/s42255-024-01002-1 Nature Metabolism, Published online: 11 March 2024; doi:10.1038/s42255-024-01002-1

Eating requires the sensing in the stomach of not only nutrients, but also volume. A study in Nature Metabolism shows that stretch activation of PIEZO1 on X/A-like cells of the stomach reduces ghrelin production and secretion, which consequently reduces food intake.]]>
Choi Sang Daniel LamM. Maya Kaelberer doi:10.1038/s42255-024-01002-1 Nature Metabolism, Published online: 2024-03-11; | doi:10.1038/s42255-024-01002-1 2024-03-11 Nature Metabolism 10.1038/s42255-024-01002-1 https://www.nature.com/articles/s42255-024-01002-1
<![CDATA[Gastric mechanosensitive channel Piezo1 regulates ghrelin production and food intake]]> https://www.nature.com/articles/s42255-024-00995-z Nature Metabolism, Published online: 11 March 2024; doi:10.1038/s42255-024-00995-z

The authors uncover the relevance of Piezo1 mechanosensors expressed in the stomach for sensing gastric distention and regulating feeding behaviour.]]>
Yawen ZhaoYang LiuTian TaoJinshan ZhangWenying GuoHandan DengMengxue HanHaocong MoXiaohan TongSong LinJie YangHening ZhaiQimeng WangZhengfang HuWeizhen ZhangHui ChenGeyang Xu doi:10.1038/s42255-024-00995-z Nature Metabolism, Published online: 2024-03-11; | doi:10.1038/s42255-024-00995-z 2024-03-11 Nature Metabolism 10.1038/s42255-024-00995-z https://www.nature.com/articles/s42255-024-00995-z
<![CDATA[Futile lipid cycling: from biochemistry to physiology]]> https://www.nature.com/articles/s42255-024-01003-0 Nature Metabolism, Published online: 08 March 2024; doi:10.1038/s42255-024-01003-0

Sharma et al. review the regulation and biological functions of apparently ‘futile’ dynamic lipid cycle in regulating whole-body metabolic homeostasis.]]>
Anand Kumar SharmaRadhika KhandelwalChristian Wolfrum doi:10.1038/s42255-024-01003-0 Nature Metabolism, Published online: 2024-03-08; | doi:10.1038/s42255-024-01003-0 2024-03-08 Nature Metabolism 10.1038/s42255-024-01003-0 https://www.nature.com/articles/s42255-024-01003-0
<![CDATA[Regulation of urea cycle by reversible high-stoichiometry lysine succinylation]]> https://www.nature.com/articles/s42255-024-01005-y Nature Metabolism, Published online: 06 March 2024; doi:10.1038/s42255-024-01005-y

Zhang, Fang, et al. develop a method to perform an in-depth lysine succinylation analysis in the mouse liver. This approach allows them to identify a previously unappreciated mechanism of regulation of the urea cycle and ammonia detoxification.]]>
Ran ZhangJingqi FangXueshu XieChris CarricoJesse G. MeyerLei WeiJoanna BonsJacob RoseRebeccah RileyRyan KwokPrasanna Vadhana Ashok KumaarYini ZhangWenjuan HeYuya NishidaXiaojing LiuJason W. LocasaleBirgit SchillingEric Verdin doi:10.1038/s42255-024-01005-y Nature Metabolism, Published online: 2024-03-06; | doi:10.1038/s42255-024-01005-y 2024-03-06 Nature Metabolism 10.1038/s42255-024-01005-y https://www.nature.com/articles/s42255-024-01005-y
<![CDATA[Glycogen from spinal astrocytes dials up the pain]]> https://www.nature.com/articles/s42255-024-01000-3 Nature Metabolism, Published online: 05 March 2024; doi:10.1038/s42255-024-01000-3

A recent study in Nature Metabolism uncovers a mechanism for pain sensitization that involves a regulatory protein of glycogen metabolism in spinal astrocytes. Targeting this protein, or the lactate fluxes linked to glycogen breakdown, may provide novel opportunities for pain management.]]>
Carlos Manlio Díaz-García doi:10.1038/s42255-024-01000-3 Nature Metabolism, Published online: 2024-03-05; | doi:10.1038/s42255-024-01000-3 2024-03-05 Nature Metabolism 10.1038/s42255-024-01000-3 https://www.nature.com/articles/s42255-024-01000-3