Nature Metabolism
Nature Metabolism will publish work from across all fields of metabolism research that significantly advances our understanding of metabolic and homeostatic processes in a cellular or broader physiological context, from fundamental cell biology to basic biomedical and translational research. At its core, the research published in Nature Metabolism will shed light on how cellular metabolism informs cellular function, on the physiology and homeostasis of organs and tissues, on the regulation of organismal energy homeostasis, and on the molecular pathophysiology of metabolic diseases, such as diabetes and obesity, or the treatment thereof.
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© 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Nature Metabolism
© 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
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Nature Metabolism
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https://www.nature.com/articles/s42255-024-01014-x
Nature Metabolism, Published online: 18 March 2024; doi:10.1038/s42255-024-01014-xThe mechanism by which metformin affects food intake remains controversial. Now, two studies link metformin treatment with the induction of the appetite-suppressing metabolite N-lactoyl-phenylalanine, which is produced by the intestine.]]>
Tara TeSlaa
doi:10.1038/s42255-024-01014-x
Nature Metabolism, Published online: 2024-03-18; | doi:10.1038/s42255-024-01014-x
2024-03-18
Nature Metabolism
10.1038/s42255-024-01014-x
https://www.nature.com/articles/s42255-024-01014-x
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https://www.nature.com/articles/s42255-024-01018-7
Nature Metabolism, Published online: 18 March 2024; doi:10.1038/s42255-024-01018-7Metformin treatment was found to be associated with acute increases in the appetite-suppressing metabolite Lac-Phe in several human observational and interventional studies.]]>
Barry ScottEmily A. DayKatie L. O’BrienJohn ScanlanGrace CromwellAine Ni ScannailMarie E. McDonnellDavid K. FinlayLydia Lynch
doi:10.1038/s42255-024-01018-7
Nature Metabolism, Published online: 2024-03-18; | doi:10.1038/s42255-024-01018-7
2024-03-18
Nature Metabolism
10.1038/s42255-024-01018-7
https://www.nature.com/articles/s42255-024-01018-7
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https://www.nature.com/articles/s42255-024-00999-9
Nature Metabolism, Published online: 18 March 2024; doi:10.1038/s42255-024-00999-9Metformin is shown to trigger production and release of Lac-Phe from gut epithelial cells, which is required for its effects on food intake and loss of body weight.]]>
Shuke XiaoVeronica L. LiXuchao LyuXudong ChenWei WeiFahim AbbasiJoshua W. KnowlesAlan Sheng-Hwa TungShuliang DengGaurav TiwariXu ShiShuning ZhengLaurie FarrellZsu-Zsu ChenKent D. TaylorXiuqing GuoMark O. GoodarziAlexis C. WoodYii-Der Ida ChenLeslie A. LangeStephen S. RichJerome I. RotterClary B. ClishUsman A. TahirRobert E. GersztenMark D. BensonJonathan Z. Long
doi:10.1038/s42255-024-00999-9
Nature Metabolism, Published online: 2024-03-18; | doi:10.1038/s42255-024-00999-9
2024-03-18
Nature Metabolism
10.1038/s42255-024-00999-9
https://www.nature.com/articles/s42255-024-00999-9
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https://www.nature.com/articles/s42255-024-01002-1
Nature Metabolism, Published online: 11 March 2024; doi:10.1038/s42255-024-01002-1Eating requires the sensing in the stomach of not only nutrients, but also volume. A study in Nature Metabolism shows that stretch activation of PIEZO1 on X/A-like cells of the stomach reduces ghrelin production and secretion, which consequently reduces food intake.]]>
Choi Sang Daniel LamM. Maya Kaelberer
doi:10.1038/s42255-024-01002-1
Nature Metabolism, Published online: 2024-03-11; | doi:10.1038/s42255-024-01002-1
2024-03-11
Nature Metabolism
10.1038/s42255-024-01002-1
https://www.nature.com/articles/s42255-024-01002-1
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https://www.nature.com/articles/s42255-024-00995-z
Nature Metabolism, Published online: 11 March 2024; doi:10.1038/s42255-024-00995-zThe authors uncover the relevance of Piezo1 mechanosensors expressed in the stomach for sensing gastric distention and regulating feeding behaviour.]]>
Yawen ZhaoYang LiuTian TaoJinshan ZhangWenying GuoHandan DengMengxue HanHaocong MoXiaohan TongSong LinJie YangHening ZhaiQimeng WangZhengfang HuWeizhen ZhangHui ChenGeyang Xu
doi:10.1038/s42255-024-00995-z
Nature Metabolism, Published online: 2024-03-11; | doi:10.1038/s42255-024-00995-z
2024-03-11
Nature Metabolism
10.1038/s42255-024-00995-z
https://www.nature.com/articles/s42255-024-00995-z
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https://www.nature.com/articles/s42255-024-01003-0
Nature Metabolism, Published online: 08 March 2024; doi:10.1038/s42255-024-01003-0Sharma et al. review the regulation and biological functions of apparently ‘futile’ dynamic lipid cycle in regulating whole-body metabolic homeostasis.]]>
Anand Kumar SharmaRadhika KhandelwalChristian Wolfrum
doi:10.1038/s42255-024-01003-0
Nature Metabolism, Published online: 2024-03-08; | doi:10.1038/s42255-024-01003-0
2024-03-08
Nature Metabolism
10.1038/s42255-024-01003-0
https://www.nature.com/articles/s42255-024-01003-0
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https://www.nature.com/articles/s42255-024-01005-y
Nature Metabolism, Published online: 06 March 2024; doi:10.1038/s42255-024-01005-yZhang, Fang, et al. develop a method to perform an in-depth lysine succinylation analysis in the mouse liver. This approach allows them to identify a previously unappreciated mechanism of regulation of the urea cycle and ammonia detoxification.]]>
Ran ZhangJingqi FangXueshu XieChris CarricoJesse G. MeyerLei WeiJoanna BonsJacob RoseRebeccah RileyRyan KwokPrasanna Vadhana Ashok KumaarYini ZhangWenjuan HeYuya NishidaXiaojing LiuJason W. LocasaleBirgit SchillingEric Verdin
doi:10.1038/s42255-024-01005-y
Nature Metabolism, Published online: 2024-03-06; | doi:10.1038/s42255-024-01005-y
2024-03-06
Nature Metabolism
10.1038/s42255-024-01005-y
https://www.nature.com/articles/s42255-024-01005-y
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https://www.nature.com/articles/s42255-024-01000-3
Nature Metabolism, Published online: 05 March 2024; doi:10.1038/s42255-024-01000-3A recent study in Nature Metabolism uncovers a mechanism for pain sensitization that involves a regulatory protein of glycogen metabolism in spinal astrocytes. Targeting this protein, or the lactate fluxes linked to glycogen breakdown, may provide novel opportunities for pain management.]]>
Carlos Manlio Díaz-García
doi:10.1038/s42255-024-01000-3
Nature Metabolism, Published online: 2024-03-05; | doi:10.1038/s42255-024-01000-3
2024-03-05
Nature Metabolism
10.1038/s42255-024-01000-3
https://www.nature.com/articles/s42255-024-01000-3