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  • Research Highlight |

    Changes in trade between the United Kingdom, the European Union and the rest of the world mean that goods would be imported over longer distances.

  • Letter |

    RNA-dependent DEAD-box ATPases (DDXs) regulate the dynamics of phase-separated organelles, with ATP-bound DDXs promoting phase separation, and ATP hydrolysis inducing compartment disassembly and RNA release.

    • Maria Hondele
    • , Ruchika Sachdev
    • , Stephanie Heinrich
    • , Juan Wang
    • , Pascal Vallotton
    • , Beatriz M. A. Fontoura
    •  & Karsten Weis

  • Article |

    The pore-forming and ATP-binding subunits of a mitochondrial protein complex that mediates ATP-dependent potassium currents are identified and characterized, revealing the role of this channel in mitochondrial physiology and pathologies.

    • Angela Paggio
    • , Vanessa Checchetto
    • , Antonio Campo
    • , Roberta Menabò
    • , Giulia Di Marco
    • , Fabio Di Lisa
    • , Ildiko Szabo
    • , Rosario Rizzuto
    •  & Diego De Stefani

  • Letter |

    Shot-noise measurements in copper oxides reveal paired charge carriers existing in the pseudogap above the superconducting critical temperature, shedding light on the properties of high-temperature superconductivity in these materials.

    • Panpan Zhou
    • , Liyang Chen
    • , Yue Liu
    • , Ilya Sochnikov
    • , Anthony T. Bollinger
    • , Myung-Geun Han
    • , Yimei Zhu
    • , Xi He
    • , Ivan Boz̆ović
    •  & Douglas Natelson

  • News & Views |

    Carbon has been stored in the organic layers of boreal-forest soils for hundreds of years. An analysis reveals that this carbon might be released into the atmosphere as global warming increases the frequency of wildfires.

    • Cornelia Rumpel

  • Article |

    RNA-sequencing analysis of cells in the human cortex enabled identification of diverse cell types, revealing well-conserved architecture and homologous cell types as well as extensive differences when compared with datasets covering the analogous region of the mouse brain.

    • Rebecca D. Hodge
    • , Trygve E. Bakken
    • , Jeremy A. Miller
    • , Kimberly A. Smith
    • , Eliza R. Barkan
    • , Lucas T. Graybuck
    • , Jennie L. Close
    • , Brian Long
    • , Nelson Johansen
    • , Osnat Penn
    • , Zizhen Yao
    • , Jeroen Eggermont
    • , Thomas Höllt
    • , Boaz P. Levi
    • , Soraya I. Shehata
    • , Brian Aevermann
    • , Allison Beller
    • , Darren Bertagnolli
    • , Krissy Brouner
    • , Tamara Casper
    • , Charles Cobbs
    • , Rachel Dalley
    • , Nick Dee
    • , Song-Lin Ding
    • , Richard G. Ellenbogen
    • , Olivia Fong
    • , Emma Garren
    • , Jeff Goldy
    • , Ryder P. Gwinn
    • , Daniel Hirschstein
    • , C. Dirk Keene
    • , Mohamed Keshk
    • , Andrew L. Ko
    • , Kanan Lathia
    • , Ahmed Mahfouz
    • , Zoe Maltzer
    • , Medea McGraw
    • , Thuc Nghi Nguyen
    • , Julie Nyhus
    • , Jeffrey G. Ojemann
    • , Aaron Oldre
    • , Sheana Parry
    • , Shannon Reynolds
    • , Christine Rimorin
    • , Nadiya V. Shapovalova
    • , Saroja Somasundaram
    • , Aaron Szafer
    • , Elliot R. Thomsen
    • , Michael Tieu
    • , Gerald Quon
    • , Richard H. Scheuermann
    • , Rafael Yuste
    • , Susan M. Sunkin
    • , Boudewijn Lelieveldt
    • , David Feng
    • , Lydia Ng
    • , Amy Bernard
    • , Michael Hawrylycz
    • , John W. Phillips
    • , Bosiljka Tasic
    • , Hongkui Zeng
    • , Allan R. Jones
    • , Christof Koch
    •  & Ed S. Lein

  • Review Article |

    Abiotic processes can mimic or alter the biogenic traces of early life but advances in micro- and nanoscale analyses provide evidence that—with geological contextualization—improves our ability to address this issue.

    • Emmanuelle J. Javaux

  • Article |

    The solute carrier transporter protein SLC25A44 regulates uptake of branched-chain amino acids in mitochondria of brown adipose tissue in which they are utilized for thermogenesis.

    • Takeshi Yoneshiro
    • , Qiang Wang
    • , Kazuki Tajima
    • , Mami Matsushita
    • , Hiroko Maki
    • , Kaori Igarashi
    • , Zhipeng Dai
    • , Phillip J. White
    • , Robert W. McGarrah
    • , Olga R. Ilkayeva
    • , Yann Deleye
    • , Yasuo Oguri
    • , Mito Kuroda
    • , Kenji Ikeda
    • , Huixia Li
    • , Ayano Ueno
    • , Maki Ohishi
    • , Takamasa Ishikawa
    • , Kyeongkyu Kim
    • , Yong Chen
    • , Carlos Henrique Sponton
    • , Rachana N. Pradhan
    • , Homa Majd
    • , Vanille Juliette Greiner
    • , Momoko Yoneshiro
    • , Zachary Brown
    • , Maria Chondronikola
    • , Haruya Takahashi
    • , Tsuyoshi Goto
    • , Teruo Kawada
    • , Labros Sidossis
    • , Francis C. Szoka
    • , Michael T. McManus
    • , Masayuki Saito
    • , Tomoyoshi Soga
    •  & Shingo Kajimura

  • Article |

    Cryo-electron microscopy and high-speed atomic force microscopy reveal that PIEZO1 can reversibly deform its shape towards a planar structure, which may explain how the PIEZO1 channel is gated in response to mechanical stimulation.

    • Yi-Chih Lin
    • , Yusong R. Guo
    • , Atsushi Miyagi
    • , Jesper Levring
    • , Roderick MacKinnon
    •  & Simon Scheuring

  • Editorial |

    France and Canada are establishing an international committee to advise on the ethics of artificial intelligence. The group should be supported and shielded from undue influence.

  • News & Views |

    The movement of small droplets on a substrate is governed by surface-tension forces. A technique that can tune the surface tension of robust oxide substrates for droplet manipulation could open up many applications.

    • Frieder Mugele

  • Letter |

    Soil radiocarbon dating reveals that combusted ‘legacy carbon’—soil carbon that escaped burning during previous fires—could shift the carbon balance of boreal ecosystems, resulting in a positive climate feedback.

    • Xanthe J. Walker
    • , Jennifer L. Baltzer
    • , Steven G. Cumming
    • , Nicola J. Day
    • , Christopher Ebert
    • , Scott Goetz
    • , Jill F. Johnstone
    • , Stefano Potter
    • , Brendan M. Rogers
    • , Edward A. G. Schuur
    • , Merritt R. Turetsky
    •  & Michelle C. Mack

  • News & Views |

    An analysis of the dynamics of online hate groups on social-media platforms reveals why current methods to ban hate content are ineffective, and provides the basis for four potential strategies to combat online hate.

    • Noemi Derzsy

  • Letter |

    The dynamics of interactions between hate-orientated networks on different online platforms is characterized, and a mathematical model predicts that policing on one online platform can make matters worse and generate ‘darker’ parts of the Internet.

    • N. F. Johnson
    • , R. Leahy
    • , N. Johnson Restrepo
    • , N. Velasquez
    • , M. Zheng
    • , P. Manrique
    • , P. Devkota
    •  & S. Wuchty

  • Letter |

    Titration gas chromatography is developed as an analytical method of distinguishing between lithium metal and lithium compounds within a cycled battery and assessing the amount of unreacted metallic lithium available.

    • Chengcheng Fang
    • , Jinxing Li
    • , Minghao Zhang
    • , Yihui Zhang
    • , Fan Yang
    • , Jungwoo Z. Lee
    • , Min-Han Lee
    • , Judith Alvarado
    • , Marshall A. Schroeder
    • , Yangyuchen Yang
    • , Bingyu Lu
    • , Nicholas Williams
    • , Miguel Ceja
    • , Li Yang
    • , Mei Cai
    • , Jing Gu
    • , Kang Xu
    • , Xuefeng Wang
    •  & Ying Shirley Meng

  • News & Views |

    Piezo proteins mediate the sense of touch. A near-complete structure of one such protein has been obtained, and the mechanism for converting mechanical signals into electrical ones has been probed in another.

    • Edwin W. McCleskey

  • Letter |

    The gut commensal Blautia producta secretes a lantibiotic that reduces colonization of the gut by the major pathogen vancomycin-resistant Enterococcus faecium, and transplantation of microbiota with high abundance of the lantibiotic gene enhances resistance to colonization in mice.

    • Sohn G. Kim
    • , Simone Becattini
    • , Thomas U. Moody
    • , Pavel V. Shliaha
    • , Eric R. Littmann
    • , Ruth Seok
    • , Mergim Gjonbalaj
    • , Vincent Eaton
    • , Emily Fontana
    • , Luigi Amoretti
    • , Roberta Wright
    • , Silvia Caballero
    • , Zhong-Min X. Wang
    • , Hea-Jin Jung
    • , Sejal M. Morjaria
    • , Ingrid M. Leiner
    • , Weige Qin
    • , Ruben J. J. F. Ramos
    • , Justin R. Cross
    • , Seiko Narushima
    • , Kenya Honda
    • , Jonathan U. Peled
    • , Ronald C. Hendrickson
    • , Ying Taur
    • , Marcel R. M. van den Brink
    •  & Eric G. Pamer

  • News & Views |

    Whether cell types in the brain have been conserved during evolution is not clear. A comparison of the molecular recipes that define brain cell types in humans and mice reveals similarities and differences between species.

    • Matthew G. Keefe
    •  & Tomasz J. Nowakowski

  • Article |

    PIEZO1 signalling mediates activation of a proinflammatory response to cyclical pressure fluctuations in immune cells.

    • Angel G. Solis
    • , Piotr Bielecki
    • , Holly R. Steach
    • , Lokesh Sharma
    • , Christian C. D. Harman
    • , Sanguk Yun
    • , Marcel R. de Zoete
    • , James N. Warnock
    • , S. D. Filip To
    • , Autumn G. York
    • , Matthias Mack
    • , Martin A. Schwartz
    • , Charles. S. Dela Cruz
    • , Noah W. Palm
    • , Ruaidhrí Jackson
    •  & Richard A. Flavell

  • News & Views |

    Immune cells called monocytes enter the lung during infection. Whether they help to launch a defence response is affected by the pressure encountered there, which is sensed by an ion channel called PIEZO1.

    • Sarah R. Walmsley

  • Article |

    The cryo-electron microscopy structure of mouse PIEZO2 is determined and compared to that of PIEZO1, providing insights into the potential gating mechanisms of these mechanosensitive ion channels.

    • Li Wang
    • , Heng Zhou
    • , Mingmin Zhang
    • , Wenhao Liu
    • , Tuan Deng
    • , Qiancheng Zhao
    • , Yiran Li
    • , Jianlin Lei
    • , Xueming Li
    •  & Bailong Xiao

  • News |

    The country’s artificial-intelligence research is growing in quality, but the field still plays catch up to the United States in terms of high-impact papers, people and ethics.

    • Sarah O’Meara

  • Editorial |

    India’s doctors and its government are at loggerheads over much-needed changes to medical education. Differences must be settled and cool heads must prevail.

  • Comment |

    Better regulation, flight control, batteries and software would improve the range of craft and data quality, argue Nicholas C. Coops, Tristan R. H. Goodbody and Lin Cao.

    • Nicholas C. Coops
    • , Tristan R. H. Goodbody
    •  & Lin Cao

  • News & Views |

    How Nature reported early experiments on magnetic data storage in 1969, and an alternative stuffing for lifebelts in 1919.

  • News |

    Researchers say that Irina Artemieva’s dismissal from the University of Copenhagen runs counter to international academic standards.

    • Quirin Schiermeier