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  • Nature Briefing |

    The real theory of everything might be “the question to which the universe is the answer”. Plus: why some US researchers are taking their gene-edited livestock abroad.

    • Flora Graham

  • News |

    Synthetic DNA seems to behave like the natural variety, suggesting that chemicals beyond nature’s four familiar bases could support life on Earth.

    • Matthew Warren

  • Letter |

    The interphase centrosome protein AKNA is necessary and sufficient for the organization of centrosomal microtubules, mediates delamination in the formation of the subventricular zone and regulates exit from this zone.

    • Germán Camargo Ortega
    • , Sven Falk
    • , Pia A. Johansson
    • , Elise Peyre
    • , Loïc Broix
    • , Sanjeeb Kumar Sahu
    • , William Hirst
    • , Thomas Schlichthaerle
    • , Camino De Juan Romero
    • , Kalina Draganova
    • , Stanislav Vinopal
    • , Kaviya Chinnappa
    • , Anna Gavranovic
    • , Tugay Karakaya
    • , Thomas Steininger
    • , Juliane Merl-Pham
    • , Regina Feederle
    • , Wei Shao
    • , Song-Hai Shi
    • , Stefanie M. Hauck
    • , Ralf Jungmann
    • , Frank Bradke
    • , Victor Borrell
    • , Arie Geerlof
    • , Simone Reber
    • , Vijay K. Tiwari
    • , Wieland B. Huttner
    • , Michaela Wilsch-Bräuninger
    • , Laurent Nguyen
    •  & Magdalena Götz

  • News & Views |

    Hippocamp, a previously undetected moon of Neptune, has a peculiar location and a tiny size relative to the planet’s other inner moons, which suggests a violent history for the region within 100,000 kilometres of the planet.

    • Anne J. Verbiscer

  • Retraction |

    • Heba Samaha
    • , Antonella Pignata
    • , Kristen Fousek
    • , Jun Ren
    • , Fong W. Lam
    • , Fabio Stossi
    • , Julien Dubrulle
    • , Vita S. Salsman
    • , Shanmugarajan Krishnan
    • , Sung-Ha Hong
    • , Matthew L. Baker
    • , Ankita Shree
    • , Ahmed Z. Gad
    • , Thomas Shum
    • , Dai Fukumura
    • , Tiara T. Byrd
    • , Malini Mukherjee
    • , Sean P. Marrelli
    • , Jordan S. Orange
    • , Sujith K. Joseph
    • , Poul H. Sorensen
    • , Michael D. Taylor
    • , Meenakshi Hegde
    • , Maksim Mamonkin
    • , Rakesh K. Jain
    • , Shahenda El-Naggar
    •  & Nabil Ahmed

  • Author Correction |

    • Axel Timmermann
    • , Soon-Il An
    • , Jong-Seong Kug
    • , Fei-Fei Jin
    • , Wenju Cai
    • , Antonietta Capotondi
    • , Kim M. Cobb
    • , Matthieu Lengaigne
    • , Michael J. McPhaden
    • , Malte F. Stuecker
    • , Karl Stein
    • , Andrew T. Wittenberg
    • , Kyung-Sook Yun
    • , Tobias Bayr
    • , Han-Ching Chen
    • , Yoshimitsu Chikamoto
    • , Boris Dewitte
    • , Dietmar Dommenget
    • , Pamela Grothe
    • , Eric Guilyardi
    • , Yoo-Geun Ham
    • , Michiya Hayashi
    • , Sarah Ineson
    • , Daehyun Kang
    • , Sunyong Kim
    • , WonMoo Kim
    • , June-Yi Lee
    • , Tim Li
    • , Jing-Jia Luo
    • , Shayne McGregor
    • , Yann Planton
    • , Scott Power
    • , Harun Rashid
    • , Hong-Li Ren
    • , Agus Santoso
    • , Ken Takahashi
    • , Alexander Todd
    • , Guomin Wang
    • , Guojian Wang
    • , Ruihuang Xie
    • , Woo-Hyun Yang
    • , Sang-Wook Yeh
    • , Jinho Yoon
    • , Elke Zeller
    •  & Xuebin Zhang

  • Article |

    A bacterial family of cGAS/DncV-like nucleotidyltransferases synthesizes a diverse range of cyclic dinucleotide and trinucleotide compounds that are likely to modulate the interaction of both pathogens and commensal microbiota with their animal and plant hosts.

    • Aaron T. Whiteley
    • , James B. Eaglesham
    • , Carina C. de Oliveira Mann
    • , Benjamin R. Morehouse
    • , Brianna Lowey
    • , Eric A. Nieminen
    • , Olga Danilchanka
    • , David S. King
    • , Amy S. Y. Lee
    • , John J. Mekalanos
    •  & Philip J. Kranzusch

  • News & Views |

    Faulty DNA replication can make genomes unstable. It now seems that, in mice, severe disruption of DNA replication triggers inflammation in the placenta, and female embryos are more sensitive to this than are male ones.

    • Sarah Lambert

  • Letter |

    Simultaneous high-precision measurements of the EMC effect and short-range correlated abundances for several nuclei reveal a universal modification of the structure of nucleons in short-range correlated neutron–proton pairs.

    • B. Schmookler
    • , M. Duer
    • , A. Schmidt
    • , O. Hen
    • , S. Gilad
    • , E. Piasetzky
    • , M. Strikman
    • , L. B. Weinstein
    • , S. Adhikari
    • , M. Amaryan
    • , A. Ashkenazi
    • , H. Avakian
    • , J. Ball
    • , I. Balossino
    • , L. Barion
    • , M. Bashkanov
    • , M. Battaglieri
    • , A. Beck
    • , I. Bedlinskiy
    • , A. S. Biselli
    • , S. Boiarinov
    • , W. J. Briscoe
    • , W. K. Brooks
    • , V. D. Burkert
    • , D. S. Carman
    • , A. Celentano
    • , G. Charles
    • , T. Chetry
    • , G. Ciullo
    • , E. Cohen
    • , P. L. Cole
    • , V. Crede
    • , R. Cruz-Torres
    • , A. D’Angelo
    • , N. Dashyan
    • , E. De Sanctis
    • , R. De Vita
    • , A. Deur
    • , S. Diehl
    • , C. Djalali
    • , R. Dupre
    • , H. Egiyan
    • , L. El Fassi
    • , L. Elouadrhiri
    • , P. Eugenio
    • , G. Fedotov
    • , R. Fersch
    • , A. Filippi
    • , T. A. Forest
    • , G. Gavalian
    • , G. P. Gilfoyle
    • , F. X. Girod
    • , E. Golovatch
    • , R. W. Gothe
    • , K. A. Griffioen
    • , M. Guidal
    • , L. Guo
    • , K. Hafidi
    • , H. Hakobyan
    • , C. Hanretty
    • , N. Harrison
    • , F. Hauenstein
    • , T. B. Hayward
    • , K. Hicks
    • , D. Higinbotham
    • , M. Holtrop
    • , C. E. Hyde
    • , Y. Ilieva
    • , D. G. Ireland
    • , B. S. Ishkhanov
    • , E. L. Isupov
    • , H.-S. Jo
    • , S. Johnston
    • , K. Joo
    • , S. Joosten
    • , M. L. Kabir
    • , D. Keller
    • , G. Khachatryan
    • , M. Khachatryan
    • , M. Khandaker
    • , A. Kim
    • , W. Kim
    • , A. Klein
    • , F. J. Klein
    • , I. Korover
    • , V. Kubarovsky
    • , S. E. Kuhn
    • , S. V. Kuleshov
    • , L. Lanza
    • , G. Laskaris
    • , P. Lenisa
    • , K. Livingston
    • , I. J. D. MacGregor
    • , N. Markov
    • , B. McKinnon
    • , S. Mey-Tal Beck
    • , T. Mineeva
    • , M. Mirazita
    • , V. Mokeev
    • , R. A. Montgomery
    • , C. Munoz Camacho
    • , B. Mustapha
    • , S. Niccolai
    • , M. Osipenko
    • , A. I. Ostrovidov
    • , M. Paolone
    • , R. Paremuzyan
    • , K. Park
    • , E. Pasyuk
    • , M. Patsyuk
    • , O. Pogorelko
    • , J. W. Price
    • , Y. Prok
    • , D. Protopopescu
    • , M. Ripani
    • , D. Riser
    • , A. Rizzo
    • , G. Rosner
    • , P. Rossi
    • , F. Sabatié
    • , C. Salgado
    • , R. A. Schumacher
    • , E. P. Segarra
    • , Y. G. Sharabian
    • , I. U. Skorodumina
    • , D. Sokhan
    • , N. Sparveris
    • , S. Stepanyan
    • , S. Strauch
    • , M. Taiuti
    • , J. A. Tan
    • , M. Ungaro
    • , H. Voskanyan
    • , E. Voutier
    • , D. P. Watts
    • , X. Wei
    • , M. Wood
    • , N. Zachariou
    • , J. Zhang
    • , Z. W. Zhao
    •  & X. Zheng

  • News & Views |

    The structure of a neutron or a proton is modified when the particle is bound in an atomic nucleus. Experimental data suggest an explanation for this phenomenon that could have broad implications for nuclear physics.

    • Gerald Feldman

  • Letter |

    Hubble Space Telescope observations of the seventh inner moon of Neptune, Hippocamp, show that it is smaller than the other six, orbits near Proteus and probably originates from a fragment of Proteus.

    • M. R. Showalter
    • , I. de Pater
    • , J. J. Lissauer
    •  & R. S. French

  • News & Views |

    Studies of multiple sclerosis have long focused on the white matter of the brain. Insights into how immune cells target the brain’s grey matter now illuminate the stage of the disease at which neurodegeneration occurs.

    • Jenna L. Pappalardo
    •  & David A. Hafler

  • Article |

    In a rat model of multiple sclerosis, β-synuclein-specific T cells induce inflammation and pathological changes in the grey matter of the central nervous system; these cells were also found in higher numbers in patients with multiple sclerosis, particularly those with a chronic progressive course.

    • Dmitri Lodygin
    • , Moritz Hermann
    • , Nils Schweingruber
    • , Cassandra Flügel-Koch
    • , Takashi Watanabe
    • , Corinna Schlosser
    • , Arianna Merlini
    • , Henrike Körner
    • , Hsin-Fang Chang
    • , Henrike J. Fischer
    • , Holger M. Reichardt
    • , Marta Zagrebelsky
    • , Brit Mollenhauer
    • , Sebastian Kügler
    • , Dirk Fitzner
    • , Jens Frahm
    • , Christine Stadelmann
    • , Michael Haberl
    • , Francesca Odoardi
    •  & Alexander Flügel

  • Article |

    Single-cell profiling is used to create a molecular-level atlas of cell differentiation trajectories during gastrulation and early organogenesis in the mouse.

    • Blanca Pijuan-Sala
    • , Jonathan A. Griffiths
    • , Carolina Guibentif
    • , Tom W. Hiscock
    • , Wajid Jawaid
    • , Fernando J. Calero-Nieto
    • , Carla Mulas
    • , Ximena Ibarra-Soria
    • , Richard C. V. Tyser
    • , Debbie Lee Lian Ho
    • , Wolf Reik
    • , Shankar Srinivas
    • , Benjamin D. Simons
    • , Jennifer Nichols
    • , John C. Marioni
    •  & Berthold Göttgens

  • Article |

    Data from single-cell combinatorial-indexing RNA-sequencing analysis of 2 million cells from mouse embryos between embryonic days 9.5 and 13.5 are compiled in a cell atlas of mouse organogenesis, which provides a global view of developmental processes occurring during this critical period.

    • Junyue Cao
    • , Malte Spielmann
    • , Xiaojie Qiu
    • , Xingfan Huang
    • , Daniel M. Ibrahim
    • , Andrew J. Hill
    • , Fan Zhang
    • , Stefan Mundlos
    • , Lena Christiansen
    • , Frank J. Steemers
    • , Cole Trapnell
    •  & Jay Shendure

  • Comment |

    Viruses hold solutions to a lot of problems, so let’s fund and reward cataloguing, urge Jens H. Kuhn and colleagues.

    • Jens H. Kuhn
    • , Yuri I. Wolf
    • , Mart Krupovic
    • , Yong-Zhen Zhang
    • , Piet Maes
    • , Valerian V. Dolja
    •  & Eugene V. Koonin

  • Career Column |

    Programming is an exercise in learning how to learn. Start small, practise often and don’t be afraid to make mistakes, advises Atma Ivancevic.

    • Atma Ivancevic

  • Letter |

    Genomic instability, caused by MCM mutations, results in embryonic lethality that disproportionally affects female mouse embryos and is rescued by testosterone or ibuprofen treatment, both of which ameliorate inflammatory effects.

    • Adrian J. McNairn
    • , Chen-Hua Chuang
    • , Jordana C. Bloom
    • , Marsha D. Wallace
    •  & John C. Schimenti

  • Letter |

    The DR isotype of the human leukocyte antigen of the MHC class II—or its homologues in bats, pigs, mice and chickens—is an essential cell entry determinant for bat influenza A viruses.

    • Umut Karakus
    • , Thiprampai Thamamongood
    • , Kevin Ciminski
    • , Wei Ran
    • , Sira C. Günther
    • , Marie O. Pohl
    • , Davide Eletto
    • , Csaba Jeney
    • , Donata Hoffmann
    • , Sven Reiche
    • , Jan Schinköthe
    • , Reiner Ulrich
    • , Julius Wiener
    • , Michael G. B. Hayes
    • , Max W. Chang
    • , Annika Hunziker
    • , Emilio Yángüez
    • , Teresa Aydillo
    • , Florian Krammer
    • , Josua Oderbolz
    • , Matthias Meier
    • , Annette Oxenius
    • , Anne Halenius
    • , Gert Zimmer
    • , Christopher Benner
    • , Benjamin G. Hale
    • , Adolfo García-Sastre
    • , Martin Beer
    • , Martin Schwemmle
    •  & Silke Stertz

  • Futures |

    Out of the frying pan, into the fire.

    • Alex Shvartsman