Browse Articles

  • Career Column |

    Desiree Dickerson risked burning out while creating a series of online well-being workshops. During lockdown, she was forced to put her perfectionism in its place.

    • Desiree Dickerson
  • Publisher Correction |

    • X. Wu
    • , M. Delbianco
    • , K. Anggara
    • , T. Michnowicz
    • , A. Pardo-Vargas
    • , P. Bharate
    • , S. Sen
    • , M. Pristl
    • , S. Rauschenbach
    • , U. Schlickum
    • , S. Abb
    • , P. H. Seeberger
    •  & K. Kern
  • Publisher Correction |

    • Peter Plavchan
    • , Thomas Barclay
    • , Jonathan Gagné
    • , Peter Gao
    • , Bryson Cale
    • , William Matzko
    • , Diana Dragomir
    • , Sam Quinn
    • , Dax Feliz
    • , Keivan Stassun
    • , Ian J. M. Crossfield
    • , David A. Berardo
    • , David W. Latham
    • , Ben Tieu
    • , Guillem Anglada-Escudé
    • , George Ricker
    • , Roland Vanderspek
    • , Sara Seager
    • , Joshua N. Winn
    • , Jon M. Jenkins
    • , Stephen Rinehart
    • , Akshata Krishnamurthy
    • , Scott Dynes
    • , John Doty
    • , Fred Adams
    • , Dennis A. Afanasev
    • , Chas Beichman
    • , Mike Bottom
    • , Brendan P. Bowler
    • , Carolyn Brinkworth
    • , Carolyn J. Brown
    • , Andrew Cancino
    • , David R. Ciardi
    • , Mark Clampin
    • , Jake T. Clark
    • , Karen Collins
    • , Cassy Davison
    • , Daniel Foreman-Mackey
    • , Elise Furlan
    • , Eric J. Gaidos
    • , Claire Geneser
    • , Frank Giddens
    • , Emily Gilbert
    • , Ryan Hall
    • , Coel Hellier
    • , Todd Henry
    • , Jonathan Horner
    • , Andrew W. Howard
    • , Chelsea Huang
    • , Joseph Huber
    • , Stephen R. Kane
    • , Matthew Kenworthy
    • , John Kielkopf
    • , David Kipping
    • , Chris Klenke
    • , Ethan Kruse
    • , Natasha Latouf
    • , Patrick Lowrance
    • , Bertrand Mennesson
    • , Matthew Mengel
    • , Sean M. Mills
    • , Tim Morton
    • , Norio Narita
    • , Elisabeth Newton
    • , America Nishimoto
    • , Jack Okumura
    • , Enric Palle
    • , Joshua Pepper
    • , Elisa V. Quintana
    • , Aki Roberge
    • , Veronica Roccatagliata
    • , Joshua E. Schlieder
    • , Angelle Tanner
    • , Johanna Teske
    • , C. G. Tinney
    • , Andrew Vanderburg
    • , Kaspar von Braun
    • , Bernie Walp
    • , Jason Wang
    • , Sharon Xuesong Wang
    • , Denise Weigand
    • , Russel White
    • , Robert A. Wittenmyer
    • , Duncan J. Wright
    • , Allison Youngblood
    • , Hui Zhang
    •  & Perri Zilberman
  • Author Correction |

    • Jinseo Park
    • , Ziao Fu
    • , Aurel Frangaj
    • , Jonathan Liu
    • , Lidia Mosyak
    • , Tong Shen
    • , Vesna N. Slavkovich
    • , Kimberly M. Ray
    • , Jaume Taura
    • , Baohua Cao
    • , Yong Geng
    • , Hao Zuo
    • , Yongjun Kou
    • , Robert Grassucci
    • , Shaoxia Chen
    • , Zheng Liu
    • , Xin Lin
    • , Justin P. Williams
    • , William J. Rice
    • , Edward T. Eng
    • , Rick K. Huang
    • , Rajesh K. Soni
    • , Brian Kloss
    • , Zhiheng Yu
    • , Jonathan A. Javitch
    • , Wayne A. Hendrickson
    • , Paul A. Slesinger
    • , Matthias Quick
    • , Joseph Graziano
    • , Hongtao Yu
    • , Oliver Fiehn
    • , Oliver B. Clarke
    • , Joachim Frank
    •  & Qing R. Fan
  • Article |

    In mice, periodic fasting or a fasting-mimicking diet enhances the efficacy of endocrine therapy for breast cancer and delays acquired resistance to it; in patients with breast cancer, a fasting-mimicking diet recreates the metabolic changes observed in mice.

    • Irene Caffa
    • , Vanessa Spagnolo
    • , Claudio Vernieri
    • , Francesca Valdemarin
    • , Pamela Becherini
    • , Min Wei
    • , Sebastian Brandhorst
    • , Chiara Zucal
    • , Else Driehuis
    • , Lorenzo Ferrando
    • , Francesco Piacente
    • , Alberto Tagliafico
    • , Michele Cilli
    • , Luca Mastracci
    • , Valerio G. Vellone
    • , Silvano Piazza
    • , Anna Laura Cremonini
    • , Raffaella Gradaschi
    • , Carolina Mantero
    • , Mario Passalacqua
    • , Alberto Ballestrero
    • , Gabriele Zoppoli
    • , Michele Cea
    • , Annalisa Arrighi
    • , Patrizio Odetti
    • , Fiammetta Monacelli
    • , Giulia Salvadori
    • , Salvatore Cortellino
    • , Hans Clevers
    • , Filippo De Braud
    • , Samir G. Sukkar
    • , Alessandro Provenzani
    • , Valter D. Longo
    •  & Alessio Nencioni
  • News & Views |

    The strength of the interactions between electrons in a structure called twisted bilayer graphene has been tuned by adjusting the immediate environment — a major advance for tunable electronic quantum matter.

    • Ronny Thomale
  • Article |

    • Seth J. Zost
    • , Pavlo Gilchuk
    • , James Brett Case
    • , Elad Binshtein
    • , Rita E. Chen
    • , Joseph P. Nkolola
    • , Alexandra Schäfer
    • , Joseph X. Reidy
    • , Andrew Trivette
    • , Rachel S. Nargi
    • , Rachel E. Sutton
    • , Naveenchandra Suryadevara
    • , David R. Martinez
    • , Lauren E. Williamson
    • , Elaine C. Chen
    • , Taylor Jones
    • , Samuel Day
    • , Luke Myers
    • , Ahmed O. Hassan
    • , Natasha M. Kafai
    • , Emma S. Winkler
    • , Julie M. Fox
    • , Swathi Shrihari
    • , Benjamin K. Mueller
    • , Jens Meiler
    • , Abishek Chandrashekar
    • , Noe B. Mercado
    • , James J. Steinhardt
    • , Kuishu Ren
    • , Yueh-Ming Loo
    • , Nicole L. Kallewaard
    • , Broc T. McCune
    • , Shamus P. Keeler
    • , Michael J. Holtzman
    • , Dan H. Barouch
    • , Lisa E. Gralinski
    • , Ralph S. Baric
    • , Larissa B. Thackray
    • , Michael S. Diamond
    • , Robert H. Carnahan
    •  & James E. Crowe Jr
  • News & Views |

    A clinical trial has tested the use of gene-sequencing results for lung cancer to match patients to targeted therapies. Some paired treatments were a good fit, but others did not succeed, for reasons that will require further exploration.

    • Alexander Drilon
    •  & Matthew D. Hellmann
  • News & Views |

    The prolonged cold of winter is required for the flowering of many plants. Now the identification of a previously unknown long-term cold-sensing mechanism helps to reveal how plants are able to time their flowering correctly.

    • Hiroyuki Iida
    •  & Ari Pekka Mähönen
  • News & Views |

    Rice in deepwater paddy fields can survive a slow-rising flood by a remarkably rapid elongation of submerged stem sections. Two genes discovered to affect this process could aid targeted improvements in crop height and flood tolerance.

    • Julia Bailey-Serres
    •  & Laurentius A. C. J. Voesenek
  • Article |

    Current outcomes are reported from the ongoing National Lung Matrix Trial, an umbrella trial for the treatment of non-small-cell lung cancer in which patients are triaged according to their tumour genotype and matched with targeted therapeutic agents.

    • Gary Middleton
    • , Peter Fletcher
    • , Sanjay Popat
    • , Joshua Savage
    • , Yvonne Summers
    • , Alastair Greystoke
    • , David Gilligan
    • , Judith Cave
    • , Noelle O’Rourke
    • , Alison Brewster
    • , Elizabeth Toy
    • , James Spicer
    • , Pooja Jain
    • , Adam Dangoor
    • , Melanie Mackean
    • , Martin Forster
    • , Amanda Farley
    • , Dee Wherton
    • , Manita Mehmi
    • , Rowena Sharpe
    • , Tara C. Mills
    • , Maria Antonietta Cerone
    • , Timothy A. Yap
    • , Thomas B. K. Watkins
    • , Emilia Lim
    • , Charles Swanton
    •  & Lucinda Billingham
  • Article |

    Stem growth in rice is regulated by an accelerator gene and a decelerator gene in parallel with gibberellic acid, and the opposite selection of these genes has led to adaptations to different environments.

    • Keisuke Nagai
    • , Yoshinao Mori
    • , Shin Ishikawa
    • , Tomoyuki Furuta
    • , Rico Gamuyao
    • , Yoko Niimi
    • , Tokunori Hobo
    • , Moyuri Fukuda
    • , Mikiko Kojima
    • , Yumiko Takebayashi
    • , Atsushi Fukushima
    • , Yasuyo Himuro
    • , Masatomo Kobayashi
    • , Wataru Ackley
    • , Hiroshi Hisano
    • , Kazuhiro Sato
    • , Aya Yoshida
    • , Jianzhong Wu
    • , Hitoshi Sakakibara
    • , Yutaka Sato
    • , Hiroyuki Tsuji
    • , Takashi Akagi
    •  & Motoyuki Ashikari
  • Article |

    A single-cell transcriptomic atlas across the lifespan of the mouse, denoted Tabula Muris Senis, provides molecular information about the hallmarks of ageing in a range of tissues and cell types.

    • Nicole Almanzar
    • , Jane Antony
    • , Ankit S. Baghel
    • , Isaac Bakerman
    • , Ishita Bansal
    • , Ben A. Barres
    • , Philip A. Beachy
    • , Daniela Berdnik
    • , Biter Bilen
    • , Douglas Brownfield
    • , Corey Cain
    • , Charles K. F. Chan
    • , Michelle B. Chen
    • , Michael F. Clarke
    • , Stephanie D. Conley
    • , Spyros Darmanis
    • , Aaron Demers
    • , Kubilay Demir
    • , Antoine de Morree
    • , Tessa Divita
    • , Haley du Bois
    • , Hamid Ebadi
    • , F. Hernán Espinoza
    • , Matt Fish
    • , Qiang Gan
    • , Benson M. George
    • , Astrid Gillich
    • , Rafael Gòmez-Sjöberg
    • , Foad Green
    • , Geraldine Genetiano
    • , Xueying Gu
    • , Gunsagar S. Gulati
    • , Oliver Hahn
    • , Michael Seamus Haney
    • , Yan Hang
    • , Lincoln Harris
    • , Mu He
    • , Shayan Hosseinzadeh
    • , Albin Huang
    • , Kerwyn Casey Huang
    • , Tal Iram
    • , Taichi Isobe
    • , Feather Ives
    • , Robert C. Jones
    • , Kevin S. Kao
    • , Jim Karkanias
    • , Guruswamy Karnam
    • , Andreas Keller
    • , Aaron M. Kershner
    • , Nathalie Khoury
    • , Seung K. Kim
    • , Bernhard M. Kiss
    • , William Kong
    • , Mark A. Krasnow
    • , Maya E. Kumar
    • , Christin S. Kuo
    • , Jonathan Lam
    • , Davis P. Lee
    • , Song E. Lee
    • , Benoit Lehallier
    • , Olivia Leventhal
    • , Guang Li
    • , Qingyun Li
    • , Ling Liu
    • , Annie Lo
    • , Wan-Jin Lu
    • , Maria F. Lugo-Fagundo
    • , Anoop Manjunath
    • , Andrew P. May
    • , Ashley Maynard
    • , Aaron McGeever
    • , Marina McKay
    • , M. Windy McNerney
    • , Bryan Merrill
    • , Ross J. Metzger
    • , Marco Mignardi
    • , Dullei Min
    • , Ahmad N. Nabhan
    • , Norma F. Neff
    • , Katharine M. Ng
    • , Patricia K. Nguyen
    • , Joseph Noh
    • , Roel Nusse
    • , Róbert Pálovics
    • , Rasika Patkar
    • , Weng Chuan Peng
    • , Lolita Penland
    • , Angela Oliveira Pisco
    • , Katherine Pollard
    • , Robert Puccinelli
    • , Zhen Qi
    • , Stephen R. Quake
    • , Thomas A. Rando
    • , Eric J. Rulifson
    • , Nicholas Schaum
    • , Joe M. Segal
    • , Shaheen S. Sikandar
    • , Rahul Sinha
    • , Rene V. Sit
    • , Justin Sonnenburg
    • , Daniel Staehli
    • , Krzysztof Szade
    • , Michelle Tan
    • , Weilun Tan
    • , Cristina Tato
    • , Krissie Tellez
    • , Laughing Bear Torrez Dulgeroff
    • , Kyle J. Travaglini
    • , Carolina Tropini
    • , Margaret Tsui
    • , Lucas Waldburger
    • , Bruce M. Wang
    • , Linda J. van Weele
    • , Kenneth Weinberg
    • , Irving L. Weissman
    • , Michael N. Wosczyna
    • , Sean M. Wu
    • , Tony Wyss-Coray
    • , Jinyi Xiang
    • , Soso Xue
    • , Kevin A. Yamauchi
    • , Andrew C. Yang
    • , Lakshmi P. Yerra
    • , Justin Youngyunpipatkul
    • , Brian Yu
    • , Fabio Zanini
    • , Macy E. Zardeneta
    • , Alexander Zee
    • , Chunyu Zhao
    • , Fan Zhang
    • , Hui Zhang
    • , Martin Jinye Zhang
    • , Lu Zhou
    •  & James Zou
  • Article |

    Nanoscale toroids with a high percentage of poly-catenation and radii of up to about 13 nm are kinetically organized using fibrous supramolecular assemblies with intrinsic curvature and a solvent-mixing strategy.

    • Sougata Datta
    • , Yasuki Kato
    • , Seiya Higashiharaguchi
    • , Keisuke Aratsu
    • , Atsushi Isobe
    • , Takuho Saito
    • , Deepak D. Prabhu
    • , Yuichi Kitamoto
    • , Martin J. Hollamby
    • , Andrew J. Smith
    • , Robert Dagleish
    • , Najet Mahmoudi
    • , Luca Pesce
    • , Claudio Perego
    • , Giovanni M. Pavan
    •  & Shiki Yagai
  • Article |

    By monolithically integrating piezoelectric actuators on ultralow-loss photonic circuits, soliton microcombs—a spectrum of sharp lines over a range of optical frequencies—can be modulated at high speeds with megahertz bandwidths.

    • Junqiu Liu
    • , Hao Tian
    • , Erwan Lucas
    • , Arslan S. Raja
    • , Grigory Lihachev
    • , Rui Ning Wang
    • , Jijun He
    • , Tianyi Liu
    • , Miles H. Anderson
    • , Wenle Weng
    • , Sunil A. Bhave
    •  & Tobias J. Kippenberg
  • Article |

    A co-culture of two newly identified microorganisms—‘Candidatus Manganitrophus noduliformans’ and Ramlibacter lithotrophicus—exhibits exponential growth that is dependent on manganese(II) oxidation, demonstrating the viability of this metabolism for supporting life.

    • Hang Yu
    •  & Jared R. Leadbetter
  • Article |

    Bulk RNA sequencing of organs and plasma proteomics at different ages across the mouse lifespan is integrated with data from the Tabula Muris Senis, a transcriptomic atlas of ageing mouse tissues, to describe organ-specific changes in gene expression during ageing.

    • Nicholas Schaum
    • , Benoit Lehallier
    • , Oliver Hahn
    • , Róbert Pálovics
    • , Shayan Hosseinzadeh
    • , Song E. Lee
    • , Rene Sit
    • , Davis P. Lee
    • , Patricia Morán Losada
    • , Macy E. Zardeneta
    • , Tobias Fehlmann
    • , James T. Webber
    • , Aaron McGeever
    • , Kruti Calcuttawala
    • , Hui Zhang
    • , Daniela Berdnik
    • , Vidhu Mathur
    • , Weilun Tan
    • , Alexander Zee
    • , Michelle Tan
    • , Nicole Almanzar
    • , Jane Antony
    • , Ankit S. Baghel
    • , Isaac Bakerman
    • , Ishita Bansal
    • , Ben A. Barres
    • , Philip A. Beachy
    • , Daniela Berdnik
    • , Biter Bilen
    • , Douglas Brownfield
    • , Corey Cain
    • , Charles K. F. Chan
    • , Michelle B. Chen
    • , Michael F. Clarke
    • , Stephanie D. Conley
    • , Spyros Darmanis
    • , Aaron Demers
    • , Kubilay Demir
    • , Antoine de Morree
    • , Tessa Divita
    • , Haley du Bois
    • , Hamid Ebadi
    • , F. Hernán Espinoza
    • , Matt Fish
    • , Qiang Gan
    • , Benson M. George
    • , Astrid Gillich
    • , Rafael Gòmez-Sjöberg
    • , Foad Green
    • , Geraldine Genetiano
    • , Xueying Gu
    • , Gunsagar S. Gulati
    • , Oliver Hahn
    • , Michael Seamus Haney
    • , Yan Hang
    • , Lincoln Harris
    • , Mu He
    • , Shayan Hosseinzadeh
    • , Albin Huang
    • , Kerwyn Casey Huang
    • , Tal Iram
    • , Taichi Isobe
    • , Feather Ives
    • , Robert Jones
    • , Kevin S. Kao
    • , Jim Karkanias
    • , Guruswamy Karnam
    • , Andreas Keller
    • , Aaron M. Kershner
    • , Nathalie Khoury
    • , Seung K. Kim
    • , Bernhard M. Kiss
    • , William Kong
    • , Mark A. Krasnow
    • , Maya E. Kumar
    • , Christin S. Kuo
    • , Jonathan Y. Lam
    • , Davis P. Lee
    • , Song E. Lee
    • , Benoit Lehallier
    • , Olivia Leventhal
    • , Guang Li
    • , Qingyun Li
    • , Ling Liu
    • , Annie Lo
    • , Wan-Jin Lu
    • , Maria F. Lugo-Fagundo
    • , Anoop Manjunath
    • , Andrew P. May
    • , Ashley Maynard
    • , Aaron McGeever
    • , Marina McKay
    • , M. Windy McNerney
    • , Bryan Merrill
    • , Ross J. Metzger
    • , Marco Mignardi
    • , Dullei Min
    • , Ahmad N. Nabhan
    • , Norma F. Neff
    • , Katharine M. Ng
    • , Patricia K. Nguyen
    • , Joseph Noh
    • , Roel Nusse
    • , Róbert Pálovics
    • , Rasika Patkar
    • , Weng Chuan Peng
    • , Lolita Penland
    • , Angela Oliveira Pisco
    • , Katherine Pollard
    • , Robert Puccinelli
    • , Zhen Qi
    • , Stephen R. Quake
    • , Thomas A. Rando
    • , Eric J. Rulifson
    • , Nicholas Schaum
    • , Joe M. Segal
    • , Shaheen S. Sikandar
    • , Rahul Sinha
    • , Rene V. Sit
    • , Justin Sonnenburg
    • , Daniel Staehli
    • , Krzysztof Szade
    • , Michelle Tan
    • , Weilun Tan
    • , Cristina Tato
    • , Krissie Tellez
    • , Laughing Bear Torrez Dulgeroff
    • , Kyle J. Travaglini
    • , Carolina Tropini
    • , Margaret Tsui
    • , Lucas Waldburger
    • , Bruce M. Wang
    • , Linda J. van Weele
    • , Kenneth Weinberg
    • , Irving L. Weissman
    • , Michael N. Wosczyna
    • , Sean M. Wu
    • , Tony Wyss-Coray
    • , Jinyi Xiang
    • , Soso Xue
    • , Kevin A. Yamauchi
    • , Andrew C. Yang
    • , Lakshmi P. Yerra
    • , Justin Youngyunpipatkul
    • , Brian Yu
    • , Fabio Zanini
    • , Macy E. Zardeneta
    • , Alexander Zee
    • , Chunyu Zhao
    • , Fan Zhang
    • , Hui Zhang
    • , Martin Jinye Zhang
    • , Lu Zhou
    • , James Zou
    • , Angela Oliveira Pisco
    • , Jim Karkanias
    • , Norma F. Neff
    • , Andreas Keller
    • , Spyros Darmanis
    • , Stephen R. Quake
    •  & Tony Wyss-Coray
  • Article |

    RNA polymerase II has an unexpected function in the nucleolus, helping to drive the expression of ribosomal RNA and to protect nucleolar structure through a mechanism involving triplex R-loop structures.

    • Karan J. Abraham
    • , Negin Khosraviani
    • , Janet N. Y. Chan
    • , Aparna Gorthi
    • , Anas Samman
    • , Dorothy Y. Zhao
    • , Miling Wang
    • , Michael Bokros
    • , Elva Vidya
    • , Lauren A. Ostrowski
    • , Roxanne Oshidari
    • , Violena Pietrobon
    • , Parasvi S. Patel
    • , Arash Algouneh
    • , Rajat Singhania
    • , Yupeng Liu
    • , V. Talya Yerlici
    • , Daniel D. De Carvalho
    • , Michael Ohh
    • , Brendan C. Dickson
    • , Razq Hakem
    • , Jack F. Greenblatt
    • , Stephen Lee
    • , Alexander J. R. Bishop
    •  & Karim Mekhail
  • Article |

    The authors find that slow plant growth at low temperatures during winter reduces dilution of the transcription factor NTL8, which allows slow accumulation of NTL8 and thus the gradual increase in transcription of VIN3—a gene involved in memory of cold exposure.

    • Yusheng Zhao
    • , Rea L. Antoniou-Kourounioti
    • , Grant Calder
    • , Caroline Dean
    •  & Martin Howard
  • Article |

    A model of sequential flux bottlenecks explains a universal trade-off between steady-state growth and physiological adaptation time in bacteria exposed to fluctuating growth conditions.

    • Markus Basan
    • , Tomoya Honda
    • , Dimitris Christodoulou
    • , Manuel Hörl
    • , Yu-Fang Chang
    • , Emanuele Leoncini
    • , Avik Mukherjee
    • , Hiroyuki Okano
    • , Brian R. Taylor
    • , Josh M. Silverman
    • , Carlos Sanchez
    • , James R. Williamson
    • , Johan Paulsson
    • , Terence Hwa
    •  & Uwe Sauer
  • Article |

    Placing a single layer of tungsten diselenide in contact with twisted bilayer graphene enables superconductivity even for non-magic twist angles where insulating behavior is absent.

    • Harpreet Singh Arora
    • , Robert Polski
    • , Yiran Zhang
    • , Alex Thomson
    • , Youngjoon Choi
    • , Hyunjin Kim
    • , Zhong Lin
    • , Ilham Zaky Wilson
    • , Xiaodong Xu
    • , Jiun-Haw Chu
    • , Kenji Watanabe
    • , Takashi Taniguchi
    • , Jason Alicea
    •  & Stevan Nadj-Perge
  • Article |

    The DNA modification N6-methyladenine regulates gene expression during mouse trophoblast development by depositing at the boundaries of active chromatin and preventing its spread by antagonizing the chromatin organizer SATB1.

    • Zheng Li
    • , Shuai Zhao
    • , Raman V. Nelakanti
    • , Kaixuan Lin
    • , Tao P. Wu
    • , Myles H. Alderman III
    • , Cheng Guo
    • , Pengcheng Wang
    • , Min Zhang
    • , Wang Min
    • , Zongliang Jiang
    • , Yinsheng Wang
    • , Haitao Li
    •  & Andrew Z. Xiao
  • Article |

    Ammonia is synthesized using a dual-site approach, whereby nitrogen vacancies on LaN activate N2, which then reacts with hydrogen atoms produced over the Ni metal to give ammonia.

    • Tian-Nan Ye
    • , Sang-Won Park
    • , Yangfan Lu
    • , Jiang Li
    • , Masato Sasase
    • , Masaaki Kitano
    • , Tomofumi Tada
    •  & Hideo Hosono
  • Article |

    A single two-dimensional array of atoms trapped in an optical lattice shows a tunable cooperative subradiant optical response, acting as a single-monolayer optical mirror with controllable reflectivity.

    • Jun Rui
    • , David Wei
    • , Antonio Rubio-Abadal
    • , Simon Hollerith
    • , Johannes Zeiher
    • , Dan M. Stamper-Kurn
    • , Christian Gross
    •  & Immanuel Bloch
  • Article |

    Using single-cell lineage tracing, the authors identify TCF15 as a novel regulator of haematopoietic stem cell quiescence and self-renewal.

    • Alejo E. Rodriguez-Fraticelli
    • , Caleb Weinreb
    • , Shou-Wen Wang
    • , Rosa P. Migueles
    • , Maja Jankovic
    • , Marc Usart
    • , Allon M. Klein
    • , Sally Lowell
    •  & Fernando D. Camargo
  • Article |

    Enhanced covalency is achieved for a curium complex with curium–sulfur bonds by subjecting the compound to high pressures, indicating that pressure can be used to tune covalency in actinide compounds.

    • Joseph M. Sperling
    • , Evan J. Warzecha
    • , Cristian Celis-Barros
    • , Dumitru-Claudiu Sergentu
    • , Xiaoyu Wang
    • , Bonnie E. Klamm
    • , Cory J. Windorff
    • , Alyssa N. Gaiser
    • , Frankie D. White
    • , Drake A. Beery
    • , Alexander T. Chemey
    • , Megan A. Whitefoot
    • , Brian N. Long
    • , Kenneth Hanson
    • , Paul Kögerler
    • , Manfred Speldrich
    • , Eva Zurek
    • , Jochen Autschbach
    •  & Thomas E. Albrecht-Schönzart
  • Article |

    Historical records reveal that although 99.6% of Antarctica is defined as wilderness, areas undisturbed by humans comprise less than 32%, largely in regions of low biodiversity.

    • Rachel I. Leihy
    • , Bernard W. T. Coetzee
    • , Fraser Morgan
    • , Ben Raymond
    • , Justine D. Shaw
    • , Aleks Terauds
    • , Kees Bastmeijer
    •  & Steven L. Chown
  • News |

    Annual emissions of the greenhouse gas have risen by almost 10% in the past two decades, driven by agriculture and the gas industry.

    • Quirin Schiermeier