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  • Nature Briefing |

    In mice, acute stress depletes the stem cells that give the hairs their colour. Plus, the first genomes from ancient West African humans and why the Wuhan virus probably didn’t come from snakes.

    • Flora Graham

  • Article |

    A global study of river deltas shows a net increase in delta area by about 54 km2 yr−1 over the past 30 years, in part due to deforestation-induced sediment delivery increase.

    • J. H. Nienhuis
    • , A. D. Ashton
    • , D. A. Edmonds
    • , A. J. F. Hoitink
    • , A. J. Kettner
    • , J. C. Rowland
    •  & T. E. Törnqvist

  • News & Views |

    HIV-1 can evade the immune system by hiding out in a dormant form. Two studies describe interventions that can effectively reactivate the latent virus in animals, potentially rendering it vulnerable to immune-mediated death.

    • Mathias Lichterfeld

  • Article |

    A synthetic approach is described, for efficiently converting non-van der Waals solids into two-dimensional van der Waals transition-metal chalcogenide layers with specific phases, enabling the high-throughput production of monolayers.

    • Zhiguo Du
    • , Shubin Yang
    • , Songmei Li
    • , Jun Lou
    • , Shuqing Zhang
    • , Shuai Wang
    • , Bin Li
    • , Yongji Gong
    • , Li Song
    • , Xiaolong Zou
    •  & Pulickel M. Ajayan

  • Article |

    The interleukin-15 superagonist N-803, combined with the depletion of CD8+ lymphocytes, induced a robust and persistent reactivation of the virus in vivo in both antiretroviral-therapy-treated SIV-infected macaques and HIV-infected humanized mice.

    • Julia Bergild McBrien
    • , Maud Mavigner
    • , Lavinia Franchitti
    • , S. Abigail Smith
    • , Erick White
    • , Gregory K. Tharp
    • , Hasse Walum
    • , Kathleen Busman-Suhay
    • , Christian R. Aguilera-Sandoval
    • , William O. Thayer
    • , Rae Ann Spagnuolo
    • , Martina Kovarova
    • , Angela Wahl
    • , Barbara Cervasi
    • , David M. Margolis
    • , Thomas H. Vanderford
    • , Diane G. Carnathan
    • , Mirko Paiardini
    • , Jeffrey D. Lifson
    • , John H. Lee
    • , Jeffrey T. Safrit
    • , Steven E. Bosinger
    • , Jacob D. Estes
    • , Cynthia A. Derdeyn
    • , J. Victor Garcia
    • , Deanna A. Kulpa
    • , Ann Chahroudi
    •  & Guido Silvestri

  • Article |

    The topoisomerase Top2 and the chromatin-binding protein Hmo1 maintain under-wound and over-wound DNA at different regions within a gene and thereby modulate the topology of genes.

    • Yathish Jagadheesh Achar
    • , Mohamood Adhil
    • , Ramveer Choudhary
    • , Nick Gilbert
    •  & Marco Foiani

  • News & Views |

    The activity of calcium channels in the heart increases during what is called the fight-or-flight response. An investigation into the 50-year-old mystery of how this occurs has captured a previously overlooked suspect.

    • Xiaohan Wang
    •  & Richard W. Tsien

  • Article |

    Structural studies on the yeast transcription coactivator complex SAGA (Spt–Ada–Gcn5–acetyltransferase) provide insights into the mechanism of initiation of regulated transcription by this multiprotein complex, which is conserved among eukaryotes.

    • Gabor Papai
    • , Alexandre Frechard
    • , Olga Kolesnikova
    • , Corinne Crucifix
    • , Patrick Schultz
    •  & Adam Ben-Shem

  • Article |

    Activation of the non-canonical NF-κB signalling pathway by AZD5582 results in the induction of HIV and SIV RNA expression in the blood and tissues of antiretroviral-therapy-treated humanized mice and rhesus macaques.

    • Christopher C. Nixon
    • , Maud Mavigner
    • , Gavin C. Sampey
    • , Alyssa D. Brooks
    • , Rae Ann Spagnuolo
    • , David M. Irlbeck
    • , Cameron Mattingly
    • , Phong T. Ho
    • , Nils Schoof
    • , Corinne G. Cammon
    • , Greg K. Tharp
    • , Matthew Kanke
    • , Zhang Wang
    • , Rachel A. Cleary
    • , Amit A. Upadhyay
    • , Chandrav De
    • , Saintedym R. Wills
    • , Shane D. Falcinelli
    • , Cristin Galardi
    • , Hasse Walum
    • , Nathaniel J. Schramm
    • , Jennifer Deutsch
    • , Jeffrey D. Lifson
    • , Christine M. Fennessey
    • , Brandon F. Keele
    • , Sherrie Jean
    • , Sean Maguire
    • , Baolin Liao
    • , Edward P. Browne
    • , Robert G. Ferris
    • , Jessica H. Brehm
    • , David Favre
    • , Thomas H. Vanderford
    • , Steven E. Bosinger
    • , Corbin D. Jones
    • , Jean-Pierre Routy
    • , Nancie M. Archin
    • , David M. Margolis
    • , Angela Wahl
    • , Richard M. Dunham
    • , Guido Silvestri
    • , Ann Chahroudi
    •  & J. Victor Garcia

  • Article |

    An inorganic chemical approach to biomolecular design is used to generate ‘cages’ that can simultaneously promote symmetry and multiple modes of protein interactions.

    • Eyal Golub
    • , Rohit H. Subramanian
    • , Julian Esselborn
    • , Robert G. Alberstein
    • , Jake B. Bailey
    • , Jerika A. Chiong
    • , Xiaodong Yan
    • , Timothy Booth
    • , Timothy S. Baker
    •  & F. Akif Tezcan

  • News & Views |

    Two-dimensional materials have potential uses in flexible electronics, biosensors and water purification. A method for producing air-stable 2D materials on an industrial scale, now reported, is a key step in bringing them to market.

    • Wei Sun Leong

  • Article |

    Stress induces hair greying in mice through depletion of melanocyte stem cells, which is mediated by the activation of sympathetic nerves rather than through immune attack or adrenal stress hormones.

    • Bing Zhang
    • , Sai Ma
    • , Inbal Rachmin
    • , Megan He
    • , Pankaj Baral
    • , Sekyu Choi
    • , William A. Gonçalves
    • , Yulia Shwartz
    • , Eva M. Fast
    • , Yiqun Su
    • , Leonard I. Zon
    • , Aviv Regev
    • , Jason D. Buenrostro
    • , Thiago M. Cunha
    • , Isaac M. Chiu
    • , David E. Fisher
    •  & Ya-Chieh Hsu

  • News & Views |

    A model has been devised that quantitatively describes how the shape of a river delta is affected by sediments, tides and waves. It reveals that the area of delta land is increasing globally, as a result of human activities upstream.

    • Nick van de Giesen

  • Article |

    An in vivo approach to identify proteins whose enrichment near cardiac CaV1.2 channels changes upon β-adrenergic stimulation finds the G protein Rad, which is phosphorylated by protein kinase A, thereby relieving channel inhibition by Rad and causing an increased Ca2+ current.

    • Guoxia Liu
    • , Arianne Papa
    • , Alexander N. Katchman
    • , Sergey I. Zakharov
    • , Daniel Roybal
    • , Jessica A. Hennessey
    • , Jared Kushner
    • , Lin Yang
    • , Bi-Xing Chen
    • , Alexander Kushnir
    • , Katerina Dangas
    • , Steven P. Gygi
    • , Geoffrey S. Pitt
    • , Henry M. Colecraft
    • , Manu Ben-Johny
    • , Marian Kalocsay
    •  & Steven O. Marx

  • Article |

    ABBV-744, a selective inhibitor of the BD2 domains of BET family proteins, is effective against prostate cancer in mouse xenograft models, with lower toxicities than the dual-bromodomain BET inhibitor ABBV-075.

    • Emily J. Faivre
    • , Keith F. McDaniel
    • , Daniel H. Albert
    • , Srinivasa R. Mantena
    • , Joshua P. Plotnik
    • , Denise Wilcox
    • , Lu Zhang
    • , Mai H. Bui
    • , George S. Sheppard
    • , Le Wang
    • , Vasudha Sehgal
    • , Xiaoyu Lin
    • , Xiaoli Huang
    • , Xin Lu
    • , Tamar Uziel
    • , Paul Hessler
    • , Lloyd T. Lam
    • , Richard J. Bellin
    • , Gaurav Mehta
    • , Steve Fidanze
    • , John K. Pratt
    • , Dachun Liu
    • , Lisa A. Hasvold
    • , Chaohong Sun
    • , Sanjay C. Panchal
    • , John J. Nicolette
    • , Stacey L. Fossey
    • , Chang H. Park
    • , Kenton Longenecker
    • , Lance Bigelow
    • , Maricel Torrent
    • , Saul H. Rosenberg
    • , Warren M. Kati
    •  & Yu Shen

  • Article |

    Redox-switchable chelation is demonstrated for a carborane cluster molecule, leading to controlled chemical or electrochemical capture and release of uranyl in monophasic or biphasic model solvent systems.

    • Megan Keener
    • , Camden Hunt
    • , Timothy G. Carroll
    • , Vladimir Kampel
    • , Roman Dobrovetsky
    • , Trevor W. Hayton
    •  & Gabriel Ménard

  • Article |

    Structural studies on the yeast transcription coactivator complex SAGA (Spt–Ada–Gcn5–acetyltransferase) provide insights into the mechanism of initiation of regulated transcription by this multiprotein complex, which is conserved among eukaryotes.

    • Haibo Wang
    • , Christian Dienemann
    • , Alexandra Stützer
    • , Henning Urlaub
    • , Alan C. M. Cheung
    •  & Patrick Cramer

  • News & Views |

    Signalling from the sympathetic nervous system of mice when subjected to stress leads to the depletion of a stem-cell population in their hair follicles. This discovery sheds light on why stress turns hair prematurely grey.

    • Shayla A. Clark
    •  & Christopher D. Deppmann

  • Article |

    Genome-wide ancestry profiles of four individuals, dating to 8,000 and 3,000 years before present, from the archaeological site of Shum Laka (Cameroon) shed light on the deep population history of sub-Saharan Africa.

    • Mark Lipson
    • , Isabelle Ribot
    • , Swapan Mallick
    • , Nadin Rohland
    • , Iñigo Olalde
    • , Nicole Adamski
    • , Nasreen Broomandkhoshbacht
    • , Ann Marie Lawson
    • , Saioa López
    • , Jonas Oppenheimer
    • , Kristin Stewardson
    • , Raymond Neba’ane Asombang
    • , Hervé Bocherens
    • , Neil Bradman
    • , Brendan J. Culleton
    • , Els Cornelissen
    • , Isabelle Crevecoeur
    • , Pierre de Maret
    • , Forka Leypey Mathew Fomine
    • , Philippe Lavachery
    • , Christophe Mbida Mindzie
    • , Rosine Orban
    • , Elizabeth Sawchuk
    • , Patrick Semal
    • , Mark G. Thomas
    • , Wim Van Neer
    • , Krishna R. Veeramah
    • , Douglas J. Kennett
    • , Nick Patterson
    • , Garrett Hellenthal
    • , Carles Lalueza-Fox
    • , Scott MacEachern
    • , Mary E. Prendergast
    •  & David Reich

  • Article |

    CRISPR–Cas systems cannot eliminate temperate bacteriophages from bacterial populations and—in this context—the systems impose immunopathological costs on the host, creating selective pressures that may explain their patchy distribution in bacteria.

    • Clare Rollie
    • , Anne Chevallereau
    • , Bridget N. J. Watson
    • , Te-yuan Chyou
    • , Olivier Fradet
    • , Isobel McLeod
    • , Peter C. Fineran
    • , Chris M. Brown
    • , Sylvain Gandon
    •  & Edze R. Westra

  • Technology Feature |

    Thought leaders predict the tech developments that could have a big impact in the coming year.

    • Esther Landhuis

  • Where I Work |

    Museum entomologist Erica McAlister finds joy in the huge and growing diversity of her collections while extracting DNA from century-old specimens.

    • Amber Dance

  • News |

    Chinese officials have confirmed that the virus is spreading between people, but it’s still unclear how easily this happens.

    • Nicky Phillips
    • , Smriti Mallapaty
    •  & David Cyranoski