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  • News & Views |

    An assessment of past, present and future ice loss from the Greenland ice sheet shows that rates of loss in the twenty‑first century will be much higher than those at any time during the past 11,700 years.

    • Andy Aschwanden

  • Article |

    • Ugur Sahin
    • , Alexander Muik
    • , Evelyna Derhovanessian
    • , Isabel Vogler
    • , Lena M. Kranz
    • , Mathias Vormehr
    • , Alina Baum
    • , Kristen Pascal
    • , Jasmin Quandt
    • , Daniel Maurus
    • , Sebastian Brachtendorf
    • , Verena Lörks
    • , Julian Sikorski
    • , Rolf Hilker
    • , Dirk Becker
    • , Ann-Kathrin Eller
    • , Jan Grützner
    • , Carsten Boesler
    • , Corinna Rosenbaum
    • , Marie-Cristine Kühnle
    • , Ulrich Luxemburger
    • , Alexandra Kemmer-Brück
    • , David Langer
    • , Martin Bexon
    • , Stefanie Bolte
    • , Katalin Karikó
    • , Tania Palanche
    • , Boris Fischer
    • , Armin Schultz
    • , Pei-Yong Shi
    • , Camila Fontes-Garfias
    • , John L. Perez
    • , Kena A. Swanson
    • , Jakob Loschko
    • , Ingrid L. Scully
    • , Mark Cutler
    • , Warren Kalina
    • , Christos A. Kyratsous
    • , David Cooper
    • , Philip R. Dormitzer
    • , Kathrin U. Jansen
    •  & Özlem Türeci

  • News & Views |

    Microglia are the brain’s immune cells. A previously unknown role for microglia has now been uncovered: providing negative feedback to active neurons, to help the brain process information.

    • Thomas Pfeiffer
    •  & David Attwell

  • News Feature |

    Researchers are exploring ways to use people’s voices to diagnose coronavirus infections, dementia, depression and much more.

    • Emily Anthes

  • Article |

    Analysis of two homologous groups of fungal pericyclases demonstrates how they can catalyse either an Alder-ene reaction—which has not previously been found in nature—or a hetero-Diels–Alder reaction.

    • Masao Ohashi
    • , Cooper S. Jamieson
    • , Yujuan Cai
    • , Dan Tan
    • , Daiki Kanayama
    • , Man-Cheng Tang
    • , Sarah M. Anthony
    • , Jason V. Chari
    • , Joyann S. Barber
    • , Elias Picazo
    • , Thomas B. Kakule
    • , Shugeng Cao
    • , Neil K. Garg
    • , Jiahai Zhou
    • , K. N. Houk
    •  & Yi Tang

  • Article |

    In a rotating reactor, immiscible or pairwise-immiscible liquids organize into stable but internally agitated concentric layers, enabling multistep syntheses and separations of reaction mixtures.

    • Olgierd Cybulski
    • , Miroslaw Dygas
    • , Barbara Mikulak-Klucznik
    • , Marta Siek
    • , Tomasz Klucznik
    • , Seong Yeol Choi
    • , Robert J. Mitchell
    • , Yaroslav I. Sobolev
    •  & Bartosz A. Grzybowski

  • Article |

    Experiments and simulations show that local non-equilibrium forces exerted by self-propelled particles trapped inside a giant unilamellar lipid vesicle induce dramatic shape changes in the vesicle.

    • Hanumantha Rao Vutukuri
    • , Masoud Hoore
    • , Clara Abaurrea-Velasco
    • , Lennard van Buren
    • , Alessandro Dutto
    • , Thorsten Auth
    • , Dmitry A. Fedosov
    • , Gerhard Gompper
    •  & Jan Vermant

  • Article |

    Expression of the axon-guidance gene Slit2 in endothelium, induced by endothelial sensing of tumour-derived double-stranded RNA, promotes metastatic dissemination in mouse models of breast and lung cancer.

    • Bernardo Tavora
    • , Tobias Mederer
    • , Kai J. Wessel
    • , Simon Ruffing
    • , Mahan Sadjadi
    • , Marc Missmahl
    • , Benjamin N. Ostendorf
    • , Xuhang Liu
    • , Ji-Young Kim
    • , Olav Olsen
    • , Alana L. Welm
    • , Hani Goodarzi
    •  & Sohail F. Tavazoie

  • Article |

    A thermal detector based on a graphene monolayer operates at the threshold for circuit quantum electrodynamics applications, achieving a minimum time constant of 200 ns.

    • R. Kokkoniemi
    • , J.-P. Girard
    • , D. Hazra
    • , A. Laitinen
    • , J. Govenius
    • , R. E. Lake
    • , I. Sallinen
    • , V. Vesterinen
    • , M. Partanen
    • , J. Y. Tan
    • , K. W. Chan
    • , K. Y. Tan
    • , P. Hakonen
    •  & M. Möttönen

  • Article |

    Single-nucleus RNA-sequencing analyses of brain from humans, macaques, marmosets, mice and ferrets reveal diverse ways that interneuron populations have changed during evolution.

    • Fenna M. Krienen
    • , Melissa Goldman
    • , Qiangge Zhang
    • , Ricardo C. H. del Rosario
    • , Marta Florio
    • , Robert Machold
    • , Arpiar Saunders
    • , Kirsten Levandowski
    • , Heather Zaniewski
    • , Benjamin Schuman
    • , Carolyn Wu
    • , Alyssa Lutservitz
    • , Christopher D. Mullally
    • , Nora Reed
    • , Elizabeth Bien
    • , Laura Bortolin
    • , Marian Fernandez-Otero
    • , Jessica D. Lin
    • , Alec Wysoker
    • , James Nemesh
    • , David Kulp
    • , Monika Burns
    • , Victor Tkachev
    • , Richard Smith
    • , Christopher A. Walsh
    • , Jordane Dimidschstein
    • , Bernardo Rudy
    • , Leslie S. Kean
    • , Sabina Berretta
    • , Gord Fishell
    • , Guoping Feng
    •  & Steven A. McCarroll

  • Article |

    Experiments using an ecologically realistic 185-member bacterial synthetic community in the root system of Arabidopsis reveal that Variovorax bacteria can influence plant hormone levels to reverse the inhibitory effect of the community on root growth.

    • Omri M. Finkel
    • , Isai Salas-González
    • , Gabriel Castrillo
    • , Jonathan M. Conway
    • , Theresa F. Law
    • , Paulo José Pereira Lima Teixeira
    • , Ellie D. Wilson
    • , Connor R. Fitzpatrick
    • , Corbin D. Jones
    •  & Jeffery L. Dangl

  • Article |

    In cells with microsatellite instability, expanded TA-dinucleotide repeats form cruciform structures that stall replication forks and cause chromosome shattering in the absence of the WRN helicase.

    • Niek van Wietmarschen
    • , Sriram Sridharan
    • , William J. Nathan
    • , Anthony Tubbs
    • , Edmond M. Chan
    • , Elsa Callen
    • , Wei Wu
    • , Frida Belinky
    • , Veenu Tripathi
    • , Nancy Wong
    • , Kyla Foster
    • , Javad Noorbakhsh
    • , Kiran Garimella
    • , Abimael Cruz-Migoni
    • , Joshua A. Sommers
    • , Yongqing Huang
    • , Ashir A. Borah
    • , Jonathan T. Smith
    • , Jeremie Kalfon
    • , Nikolas Kesten
    • , Kasper Fugger
    • , Robert L. Walker
    • , Egor Dolzhenko
    • , Michael A. Eberle
    • , Bruce E. Hayward
    • , Karen Usdin
    • , Catherine H. Freudenreich
    • , Robert M. Brosh Jr
    • , Stephen C. West
    • , Peter J. McHugh
    • , Paul S. Meltzer
    • , Adam J. Bass
    •  & André Nussenzweig

  • Article |

    Rates of ice-mass loss from southwestern Greenland this century will exceed the maximum rate over the past 12,000 years, and would not be the result of natural variation.

    • Jason P. Briner
    • , Joshua K. Cuzzone
    • , Jessica A. Badgeley
    • , Nicolás E. Young
    • , Eric J. Steig
    • , Mathieu Morlighem
    • , Nicole-Jeanne Schlegel
    • , Gregory J. Hakim
    • , Joerg M. Schaefer
    • , Jesse V. Johnson
    • , Alia J. Lesnek
    • , Elizabeth K. Thomas
    • , Estelle Allan
    • , Ole Bennike
    • , Allison A. Cluett
    • , Beata Csatho
    • , Anne de Vernal
    • , Jacob Downs
    • , Eric Larour
    •  & Sophie Nowicki

  • Article |

    An ultimately thin microwave bolometric sensor based on a superconductor–graphene–superconductor Josephson junction with monolayer graphene has a sensitivity approaching the fundamental limit imposed by intrinsic thermal fluctuations.

    • Gil-Ho Lee
    • , Dmitri K. Efetov
    • , Woochan Jung
    • , Leonardo Ranzani
    • , Evan D. Walsh
    • , Thomas A. Ohki
    • , Takashi Taniguchi
    • , Kenji Watanabe
    • , Philip Kim
    • , Dirk Englund
    •  & Kin Chung Fong

  • Article |

    The supramammillary nucleus in the hypothalamus acts as a novelty hub that selectively directs different types of novelty signals to different subregions of the hippocampus and flexibly modulates the encoding of memory.

    • Shuo Chen
    • , Linmeng He
    • , Arthur J. Y. Huang
    • , Roman Boehringer
    • , Vincent Robert
    • , Marie E. Wintzer
    • , Denis Polygalov
    • , Adam Z. Weitemier
    • , Yanqiu Tao
    • , Mingxiao Gu
    • , Steven J. Middleton
    • , Kana Namiki
    • , Hiroshi Hama
    • , Ludivine Therreau
    • , Vivien Chevaleyre
    • , Hiroyuki Hioki
    • , Atsushi Miyawaki
    • , Rebecca A. Piskorowski
    •  & Thomas J. McHugh

  • Article |

    Microglia, the brain’s immune cells, suppress neuronal activity in response to synaptic ATP release and alter behavioural responses in mice.

    • Ana Badimon
    • , Hayley J. Strasburger
    • , Pinar Ayata
    • , Xinhong Chen
    • , Aditya Nair
    • , Ako Ikegami
    • , Philip Hwang
    • , Andrew T. Chan
    • , Steven M. Graves
    • , Joseph O. Uweru
    • , Carola Ledderose
    • , Munir Gunes Kutlu
    • , Michael A. Wheeler
    • , Anat Kahan
    • , Masago Ishikawa
    • , Ying-Chih Wang
    • , Yong-Hwee E. Loh
    • , Jean X. Jiang
    • , D. James Surmeier
    • , Simon C. Robson
    • , Wolfgang G. Junger
    • , Robert Sebra
    • , Erin S. Calipari
    • , Paul J. Kenny
    • , Ukpong B. Eyo
    • , Marco Colonna
    • , Francisco J. Quintana
    • , Hiroaki Wake
    • , Viviana Gradinaru
    •  & Anne Schaefer

  • Career Column |

    Registration forms, grant applications and publishing all create hurdles for single-name researchers. A culturally sensitive approach is needed.

    • Sheherazade
    •  & Ardiantiono

  • Obituary |

    Mathematician whose invention connected knots to quantum physics.

    • Davide Castelvecchi

  • Nature Briefing |

    One million deaths have been attributed to COVID-19 — and the true toll is probably even higher. Plus, three lakes discovered under Mars’s south pole and how to digitize your lab notebooks using only a smartphone.

    • Flora Graham

  • Career Column |

    Lukas Lehner wanted to capture how different economies are addressing COVID-19 challenges. His Twitter call-out helped to create a global directory of policy resources based on swarm intelligence, and led to a research project.

    • Lukas Lehner

  • Where I Work |

    Conservation scientist Ricardo Rocha seeks to discover how deforestation affects communities of bats that feast on disease-bearing insects.

    • Patricia Maia Noronha

  • News & Views |

    The cGAS–STING signalling pathway, which has a key role in antiviral immune responses in mammals, is found to have originated as an immune-defence system that protects bacteria against viral infection.

    • Justin Jenson
    •  & Zhijian J. Chen

  • Technology Feature |

    Converting paper records to digital formats provides secure back-ups that researchers can access from anywhere.

    • Anna Nowogrodzki

  • Article |

    • Alexander D. Gitlin
    • , Klaus Heger
    • , Alexander F. Schubert
    • , Rohit Reja
    • , Donghong Yan
    • , Victoria C. Pham
    • , Eric Suto
    • , Juan Zhang
    • , Youngsu C. Kwon
    • , Emily C. Freund
    • , Jing Kang
    • , Anna Pham
    • , Roger Caothien
    • , Natasha Bacarro
    • , Trent Hinkle
    • , Min Xu
    • , Brent S. McKenzie
    • , Benjamin Haley
    • , Wyne P. Lee
    • , Jennie R. Lill
    • , Merone Roose-Girma
    • , Monika Dohse
    • , Joshua D. Webster
    • , Kim Newton
    •  & Vishva M. Dixit