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Article |
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis
- Bryan A. Johnson
- , Xuping Xie
- , Adam L. Bailey
- , Birte Kalveram
- , Kumari G. Lokugamage
- , Antonio Muruato
- , Jing Zou
- , Xianwen Zhang
- , Terry Juelich
- , Jennifer K. Smith
- , Lihong Zhang
- , Nathen Bopp
- , Craig Schindewolf
- , Michelle Vu
- , Abigail Vanderheiden
- , Emma S. Winkler
- , Daniele Swetnam
- , Jessica A. Plante
- , Patricia Aguilar
- , Kenneth S. Plante
- , Vsevolod Popov
- , Benhur Lee
- , Scott C. Weaver
- , Mehul S. Suthar
- , Andrew L. Routh
- , Ping Ren
- , Zhiqiang Ku
- , Zhiqiang An
- , Kari Debbink
- , Michael S. Diamond
- , Pei Yong Shi
- , Alexander N. Freiberg
- & Vineet D. Menachery
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Research Highlight |
The moon that made Saturn a pushover
Scientists have a new theory for how the ringed planet got its tilt.
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Where I Work |
The bird librarian
Leah Tsang helps to bring bird poisoners to justice as part of her role at Australia’s oldest museum.
- James Mitchell Crow
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Research Highlight |
Found at last: the ‘Sapling Fort’ where Native Alaskans made a stand
The stout palisaded structure helped Sitka Tlingit people to force a Russian retreat in 1804.
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Book Review |
Meteorites: ‘a story written across light years down the barrel of a microscope’
Chemical clues reveal stories from the birth of the Solar System.
- Meenakshi Wadhwa
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Career Column |
My 2020 as an ‘alien’ PhD student in New York
Cecilia Zumajo-Cardona learnt three key lessons as an international graduate student in the United States, and is optimistic about 2021.
- Cecilia Zumajo-Cardona
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Career News |
‘The problem is greater than it’s ever been’: US universities urged to invest in mental-health resources
National Academies report finds that graduate students are at risk in mental-health ‘crisis’ on campuses nationwide.
- Chris Woolston
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Nature Briefing |
Daily briefing: Retracted COVID papers are still being cited
Most citations of discredited Surgisphere research fail to mention retractions. Plus, why the world’s pandemic warning system failed when COVID hit and how uncertainty can sharpen our thinking.
- Flora Graham
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News & Views |
A molecular handbook for human development
A large-scale, high-resolution cell atlas of gene expression and regulation in human embryos enables innovative investigation of development through multi‑organ and multi‑modal analysis.
- Felicia Kuperwaser
- & Itai Yanai
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News |
Why did the world’s pandemic warning system fail when COVID hit?
Nearly one year ago, the World Health Organization sounded the alarm about the coronavirus, but was ignored.
- Amy Maxmen
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Research Highlight |
A material cracks barriers to asymmetrical toughness
Precise engineering generates a structure that fractures more easily in one direction than the other.
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Research Highlight |
Chemists’ riff on melanin makes a rainbow
An adaptation to the body’s pigment formula produces particles that outshine melanin.
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Research Highlight |
Data helps an anti-rabies campaign go to the dogs
A plan uses real-time monitoring to vaccinate more than two-thirds of a city’s canines at low cost.
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Nature Briefing |
Daily briefing: How vaccines might change the course of the pandemic
The first real-world data from COVID vaccine programs. Plus, widespread discrimination in hiring has been laid bare by a mountain of data.
- Flora Graham
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Obituary |
Akito Arima (1930–2020)
Theoretician who simplified nuclear physics and revamped Japan’s science.
- David Swinbanks
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News |
Are COVID vaccination programmes working? Scientists seek first clues
Vaccinated people in Israel are less likely to test positive for SARS-CoV-2, but a population-wide effect will take time to become clear.
- Smriti Mallapaty
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Research Highlight |
A deep-sea trench is a plastic dump — and a biodiversity hotspot
Plastic bags and wrappers host a thriving community of ocean creatures.
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Career Column |
Lifelong lessons from my unexpected encounter with a synchrotron
Biomedical scientist Vladimira Foteva didn’t imagine she would be working with physicists at an Australian particle accelerator when she began her PhD, but the experience taught her the value of collaboration across disciplines.
- Vladimira Foteva
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Nature Briefing |
Daily briefing: Why cats love catnip
Catnip activates cats’ opioid systems (and protects them from mosquitos). Plus, ten computer codes that transformed science and what new SARS-CoV-2 variants mean for schools.
- Flora Graham
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News |
What new COVID variants mean for schools is not yet clear
Children are no more susceptible to these lineages than adults are — and closing schools on the basis of incomplete information could have repercussions.
- Dyani Lewis
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News |
‘Inspired choice’: Biden appoints sociologist Alondra Nelson to top science post
Scientists praise US president’s selection of the bioethics and social inequality specialist to help lead the Office of Science and Technology Policy.
- Nidhi Subbaraman
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News |
Fast-spreading COVID variant can elude immune responses
Evidence that a variant of the coronavirus identified in South Africa might compromise immunity sparks concerns about vaccine effectiveness.
- Ewen Callaway
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News |
COVID research updates: COVID vaccines might lose potency against new viral variants
Nature wades through the literature on the new coronavirus — and summarizes key papers as they appear.
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Article |
NINJ1 mediates plasma membrane rupture during lytic cell death
- Nobuhiko Kayagaki
- , Opher S. Kornfeld
- , Bettina L. Lee
- , Irma B. Stowe
- , Karen O’Rourke
- , Qingling Li
- , Wendy Sandoval
- , Donghong Yan
- , Jing Kang
- , Min Xu
- , Juan Zhang
- , Wyne P. Lee
- , Brent S. McKenzie
- , Gözde Ulas
- , Jian Payandeh
- , Merone Roose-Girma
- , Zora Modrusan
- , Rohit Reja
- , Meredith Sagolla
- , Joshua D. Webster
- , Vicky Cho
- , T. Daniel Andrews
- , Lucy X. Morris
- , Lisa A. Miosge
- , Christopher C. Goodnow
- , Edward M. Bertram
- & Vishva M. Dixit
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Research Highlight |
Massive water projects leave a parched landscape high and dry
Ambitious irrigation schemes are planned for sub-Saharan Africa — but those already built have a dismal track record.
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Nature Podcast |
Hiring discrimination laid bare by mountain of data
Analysis of hundreds of thousands of job searches shows that recruiters will discriminate based on ethnicity and gender, and the neural circuitry behind a brief period of forgetting.
- Benjamin Thompson
- & Nick Howe
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Perspective |
Lessons from the host defences of bats, a unique viral reservoir
Unique biological traits of bats and adaptive evolution associated with flight confer immunotolerance of viral infection that may help to make bats special reservoir hosts for viruses.
- Aaron T. Irving
- , Matae Ahn
- , Geraldine Goh
- , Danielle E. Anderson
- & Lin-Fa Wang
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Article |
A reprogrammable mechanical metamaterial with stable memory
A reprogrammable mechanical metamaterial constructed of bistable unit cells that can be switched independently and reversibly between two stable states with distinct mechanical properties using magnetic actuation is demonstrated.
- Tian Chen
- , Mark Pauly
- & Pedro M. Reis
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Article |
Lake heatwaves under climate change
Modelling and remote sensing show that by the end of the twenty-first century, lake heatwaves will be several degrees Celsius warmer and some will be months longer, with potentially major adverse consequences for lake ecosystems.
- R. Iestyn Woolway
- , Eleanor Jennings
- , Tom Shatwell
- , Malgorzata Golub
- , Don C. Pierson
- & Stephen C. Maberly
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Article |
A stable low-temperature H2-production catalyst by crowding Pt on α-MoC
A stable, low-temperature water–gas shift catalyst is achieved by crowding platinum atoms and clusters on α-molybdenum carbide; the crowding protects the support from oxidation that would cause catalyst deactivation.
- Xiao Zhang
- , Mengtao Zhang
- , Yuchen Deng
- , Mingquan Xu
- , Luca Artiglia
- , Wen Wen
- , Rui Gao
- , Bingbing Chen
- , Siyu Yao
- , Xiaochen Zhang
- , Mi Peng
- , Jie Yan
- , Aowen Li
- , Zheng Jiang
- , Xingyu Gao
- , Sufeng Cao
- , Ce Yang
- , A. Jeremy Kropf
- , Jinan Shi
- , Jinglin Xie
- , Mingshu Bi
- , Jeroen A. van Bokhoven
- , Yong-Wang Li
- , Xiaodong Wen
- , Maria Flytzani-Stephanopoulos
- , Chuan Shi
- , Wu Zhou
- & Ding Ma
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Article |
Dopamine-based mechanism for transient forgetting
A dopamine neuron that underpins transient forgetting in Drosophila is activated by the presentation of interfering stimuli immediately before memory retrieval, modulating this retrieval by stimulating a dopamine receptor in mushroom body neurons.
- John Martin Sabandal
- , Jacob A. Berry
- & Ronald L. Davis
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Article |
Striatal activity topographically reflects cortical activity
Simultaneous mapping of activity across the cortex and dorsal striatum in mice shows that activity in each part of the striatum precisely mirrors that in topographically associated cortical regions, consistently across behavioural contexts.
- Andrew J. Peters
- , Julie M. J. Fabre
- , Nicholas A. Steinmetz
- , Kenneth D. Harris
- & Matteo Carandini
-
Article |
Trapped fractional charges at bulk defects in topological insulators
It is experimentally shown that crystallographic defects may trap fractional charges, as well as topological states, in the bulk of topological crystalline insulators.
- Christopher W. Peterson
- , Tianhe Li
- , Wentao Jiang
- , Taylor L. Hughes
- & Gaurav Bahl
-
Article |
Monitoring hiring discrimination through online recruitment platforms
An analysis of the search behaviour of recruiters on a Swiss online recruitment platform shows that jobseekers from minority ethnic groups are less likely to be contacted by recruiters, and also provides evidence of gender-based discrimination.
- Dominik Hangartner
- , Daniel Kopp
- & Michael Siegenthaler
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Article |
Survey of spiking in the mouse visual system reveals functional hierarchy
A large, open dataset containing parallel recordings from six visual cortical and two thalamic areas of the mouse brain is presented, from which the relative timing of activity in response to visual stimuli and behaviour is used to construct a hierarchy scheme that corresponds to anatomical connectivity data.
- Joshua H. Siegle
- , Xiaoxuan Jia
- , Séverine Durand
- , Sam Gale
- , Corbett Bennett
- , Nile Graddis
- , Greggory Heller
- , Tamina K. Ramirez
- , Hannah Choi
- , Jennifer A. Luviano
- , Peter A. Groblewski
- , Ruweida Ahmed
- , Anton Arkhipov
- , Amy Bernard
- , Yazan N. Billeh
- , Dillan Brown
- , Michael A. Buice
- , Nicolas Cain
- , Shiella Caldejon
- , Linzy Casal
- , Andrew Cho
- , Maggie Chvilicek
- , Timothy C. Cox
- , Kael Dai
- , Daniel J. Denman
- , Saskia E. J. de Vries
- , Roald Dietzman
- , Luke Esposito
- , Colin Farrell
- , David Feng
- , John Galbraith
- , Marina Garrett
- , Emily C. Gelfand
- , Nicole Hancock
- , Julie A. Harris
- , Robert Howard
- , Brian Hu
- , Ross Hytnen
- , Ramakrishnan Iyer
- , Erika Jessett
- , Katelyn Johnson
- , India Kato
- , Justin Kiggins
- , Sophie Lambert
- , Jerome Lecoq
- , Peter Ledochowitsch
- , Jung Hoon Lee
- , Arielle Leon
- , Yang Li
- , Elizabeth Liang
- , Fuhui Long
- , Kyla Mace
- , Jose Melchior
- , Daniel Millman
- , Tyler Mollenkopf
- , Chelsea Nayan
- , Lydia Ng
- , Kiet Ngo
- , Thuyahn Nguyen
- , Philip R. Nicovich
- , Kat North
- , Gabriel Koch Ocker
- , Doug Ollerenshaw
- , Michael Oliver
- , Marius Pachitariu
- , Jed Perkins
- , Melissa Reding
- , David Reid
- , Miranda Robertson
- , Kara Ronellenfitch
- , Sam Seid
- , Cliff Slaughterbeck
- , Michelle Stoecklin
- , David Sullivan
- , Ben Sutton
- , Jackie Swapp
- , Carol Thompson
- , Kristen Turner
- , Wayne Wakeman
- , Jennifer D. Whitesell
- , Derric Williams
- , Ali Williford
- , Rob Young
- , Hongkui Zeng
- , Sarah Naylor
- , John W. Phillips
- , R. Clay Reid
- , Stefan Mihalas
- , Shawn R. Olsen
- & Christof Koch
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Article |
Observation of the onset of a blue jet into the stratosphere
Observations from the International Space Station show a blue jet that is initiated by an intense blue flash in the top of a thunderstorm cloud.
- Torsten Neubert
- , Olivier Chanrion
- , Matthias Heumesser
- , Krystallia Dimitriadou
- , Lasse Husbjerg
- , Ib Lundgaard Rasmussen
- , Nikolai Østgaard
- & Victor Reglero
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Article |
Restoring metabolism of myeloid cells reverses cognitive decline in ageing
In aged mice, inhibition of prostaglandin E2 (PGE2) signalling through its receptor EP2 improves cellular bioenergetics, reduces inflammatory responses and restores hippocampal plasticity to youthful levels, resulting in an improvement in spatial memory and cognition.
- Paras S. Minhas
- , Amira Latif-Hernandez
- , Melanie R. McReynolds
- , Aarooran S. Durairaj
- , Qian Wang
- , Amanda Rubin
- , Amit U. Joshi
- , Joy Q. He
- , Esha Gauba
- , Ling Liu
- , Congcong Wang
- , Miles Linde
- , Yuki Sugiura
- , Peter K. Moon
- , Ravi Majeti
- , Makoto Suematsu
- , Daria Mochly-Rosen
- , Irving L. Weissman
- , Frank M. Longo
- , Joshua D. Rabinowitz
- & Katrin I. Andreasson
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Article |
Decoding and perturbing decision states in real time
In macaque motor cortex, moment-to-moment fluctuations in neurally derived decision variables are tightly linked to decision state and predict behavioural choices with better accuracy than condition-averaged decision variables or the visual stimulus alone, and can be used to distinguish between different models of decision making.
- Diogo Peixoto
- , Jessica R. Verhein
- , Roozbeh Kiani
- , Jonathan C. Kao
- , Paul Nuyujukian
- , Chandramouli Chandrasekaran
- , Julian Brown
- , Sania Fong
- , Stephen I. Ryu
- , Krishna V. Shenoy
- & William T. Newsome
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Article |
Bulk–disclination correspondence in topological crystalline insulators
It is experimentally shown that topological states exist at crystallographic defects in the bulk and that disclination defects trap fractional charges characteristic of topological crystalline insulators.
- Yang Liu
- , Shuwai Leung
- , Fei-Fei Li
- , Zhi-Kang Lin
- , Xiufeng Tao
- , Yin Poo
- & Jian-Hua Jiang
-
Article |
Tracking break-induced replication shows that it stalls at roadblocks
A method of tracking break-induced replication reveals the details of this repair process and shows that it can be impaired by certain genomic elements and by transcription.
- Liping Liu
- , Zhenxin Yan
- , Beth A. Osia
- , Jerzy Twarowski
- , Luyang Sun
- , Juraj Kramara
- , Rosemary S. Lee
- , Sandeep Kumar
- , Rajula Elango
- , Hanzeng Li
- , Weiwei Dang
- , Grzegorz Ira
- & Anna Malkova
-
Nature Briefing |
Daily briefing: How Biden will jump start climate action on his first day
US President Joe Biden’s first day will be a green sweep, the ten greatest predictions in physics and rogue antibodies could be driving severe COVID.
- Flora Graham
-
News Feature |
Ten computer codes that transformed science
From Fortran to arXiv.org, these advances in programming and platforms sent biology, climate science and physics into warp speed.
- Jeffrey M. Perkel
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News & Views |
Reversal of immune-cell shutdown protects the ageing brain
Immune cells called macrophages have been found to shut down major metabolic pathways during ageing. Restoring metabolism in these cells is sufficient to alleviate age-associated cognitive decline in mice.
- Jonas J. Neher
-
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News & Views |
Mechanical memory written and read remotely
A device has been developed that consists of mechanical bits, analogous to the magnetic bits used in computer hard drives. Information encoded in the bits programs the mechanical properties of the device.
- Corentin Coulais
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Editorial |
How science can put the Sustainable Development Goals back on track
The COVID-19 pandemic has disrupted the UN’s flagship plan to end poverty and protect the environment. Researchers need to launch a rapid response.
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News Round-Up |
Biden’s science adviser, COVID reinfections and vaccine tests
The latest science news, in brief.
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News & Views |
Electrons broken into pieces at crystal defects
Fractional electric charges have been observed at crystal defects in artificial structures resembling materials called topological crystalline insulators. Such fractional charges could have various engineering applications.
- Carmine Ortix
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Career News |
Zoom fatigue saps grant reviewers’ attention
Referees for the US National Institutes of Health report engaging less during virtual panel meetings — but most think review quality doesn’t suffer.
- Dalmeet Singh Chawla