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  • Article |

    • Yuhei Araiso
    • , Akihisa Tsutsumi
    • , Jian Qiu
    • , Kenichiro Imai
    • , Takuya Shiota
    • , Jiyao Song
    • , Caroline Lindau
    • , Lena-Sophie Wenz
    • , Haruka Sakaue
    • , Kaori Yunoki
    • , Shin Kawano
    • , Junko Suzuki
    • , Marilena Wischnewski
    • , Conny Schütze
    • , Hirotaka Ariyama
    • , Toshio Ando
    • , Thomas Becker
    • , Trevor Lithgow
    • , Nils Wiedemann
    • , Nikolaus Pfanner
    • , Masahide Kikkawa
    •  & Toshiya Endo

  • Letter |

    Simulated mergers of two massive stars provide a solution to the long-standing puzzle of the origin of strong magnetic fields in a subset of massive stars.

    • Fabian R. N. Schneider
    • , Sebastian T. Ohlmann
    • , Philipp Podsiadlowski
    • , Friedrich K. Röpke
    • , Steven A. Balbus
    • , Rüdiger Pakmor
    •  & Volker Springel

  • Letter |

    A range of SF3B1 mutations promote tumorigenesis through the repression of BRD9, a core component of the non-canonical BAF complex, and correcting BRD9 mis-splicing in these SF3B1-mutant cells suppresses tumour growth.

    • Daichi Inoue
    • , Guo-Liang Chew
    • , Bo Liu
    • , Brittany C. Michel
    • , Joseph Pangallo
    • , Andrew R. D’Avino
    • , Tyler Hitchman
    • , Khrystyna North
    • , Stanley Chun-Wei Lee
    • , Lillian Bitner
    • , Ariele Block
    • , Amanda R. Moore
    • , Akihide Yoshimi
    • , Luisa Escobar-Hoyos
    • , Hana Cho
    • , Alex Penson
    • , Sydney X. Lu
    • , Justin Taylor
    • , Yu Chen
    • , Cigall Kadoch
    • , Omar Abdel-Wahab
    •  & Robert K. Bradley

  • Letter |

    In high-entropy alloys, atomic-resolution chemical mapping shows that swapping some of the atoms for larger, more electronegative elements results in atomic-scale modulations that produce higher yield strength, excellent strain hardening and ductility.

    • Qingqing Ding
    • , Yin Zhang
    • , Xiao Chen
    • , Xiaoqian Fu
    • , Dengke Chen
    • , Sijing Chen
    • , Lin Gu
    • , Fei Wei
    • , Hongbin Bei
    • , Yanfei Gao
    • , Minru Wen
    • , Jixue Li
    • , Ze Zhang
    • , Ting Zhu
    • , Robert O. Ritchie
    •  & Qian Yu

  • Article |

    Single-cell transcriptomic profiling of fetal liver, skin, kidney and yolk sac reveals the differentiation trajectories of human haematopoietic stem cells and multipotent progenitors, which are validated to produce an integrated map of fetal liver haematopoiesis.

    • Dorin-Mirel Popescu
    • , Rachel A. Botting
    • , Emily Stephenson
    • , Kile Green
    • , Simone Webb
    • , Laura Jardine
    • , Emily F. Calderbank
    • , Krzysztof Polanski
    • , Issac Goh
    • , Mirjana Efremova
    • , Meghan Acres
    • , Daniel Maunder
    • , Peter Vegh
    • , Yorick Gitton
    • , Jong-Eun Park
    • , Roser Vento-Tormo
    • , Zhichao Miao
    • , David Dixon
    • , Rachel Rowell
    • , David McDonald
    • , James Fletcher
    • , Elizabeth Poyner
    • , Gary Reynolds
    • , Michael Mather
    • , Corina Moldovan
    • , Lira Mamanova
    • , Frankie Greig
    • , Matthew D. Young
    • , Kerstin B. Meyer
    • , Steven Lisgo
    • , Jaume Bacardit
    • , Andrew Fuller
    • , Ben Millar
    • , Barbara Innes
    • , Susan Lindsay
    • , Michael J. T. Stubbington
    • , Monika S. Kowalczyk
    • , Bo Li
    • , Orr Ashenberg
    • , Marcin Tabaka
    • , Danielle Dionne
    • , Timothy L. Tickle
    • , Michal Slyper
    • , Orit Rozenblatt-Rosen
    • , Andrew Filby
    • , Peter Carey
    • , Alexandra-Chloé Villani
    • , Anindita Roy
    • , Aviv Regev
    • , Alain Chédotal
    • , Irene Roberts
    • , Berthold Göttgens
    • , Sam Behjati
    • , Elisa Laurenti
    • , Sarah A. Teichmann
    •  & Muzlifah Haniffa

  • News & Views |

    In the early 1950s, the identity of genetic material was still a matter of debate. The discovery of the helical structure of double-stranded DNA settled the matter — and changed biology forever.

    • Georgina Ferry

  • Perspective
    | Open Access

    HuBMAP supports technology development, data acquisition, and spatial analyses to generate comprehensive molecular and cellular three-dimensional tissue maps.

    • Michael P. Snyder
    • , Shin Lin
    • , Amanda Posgai
    • , Mark Atkinson
    • , Aviv Regev
    • , Jennifer Rood
    • , Orit Rozenblatt-Rosen
    • , Leslie Gaffney
    • , Anna Hupalowska
    • , Rahul Satija
    • , Nils Gehlenborg
    • , Jay Shendure
    • , Julia Laskin
    • , Pehr Harbury
    • , Nicholas A. Nystrom
    • , Jonathan C. Silverstein
    • , Ziv Bar-Joseph
    • , Kun Zhang
    • , Katy Börner
    • , Yiing Lin
    • , Richard Conroy
    • , Dena Procaccini
    • , Ananda L. Roy
    • , Ajay Pillai
    • , Marishka Brown
    • , Zorina S. Galis
    • , Long Cai
    • , Jay Shendure
    • , Cole Trapnell
    • , Shin Lin
    • , Dana Jackson
    • , Michael P. Snyder
    • , Garry Nolan
    • , William James Greenleaf
    • , Yiing Lin
    • , Sylvia Plevritis
    • , Sara Ahadi
    • , Stephanie A. Nevins
    • , Hayan Lee
    • , Christian Martijn Schuerch
    • , Sarah Black
    • , Vishal Gautham Venkataraaman
    • , Ed Esplin
    • , Aaron Horning
    • , Amir Bahmani
    • , Kun Zhang
    • , Xin Sun
    • , Sanjay Jain
    • , James Hagood
    • , Gloria Pryhuber
    • , Peter Kharchenko
    • , Mark Atkinson
    • , Bernd Bodenmiller
    • , Todd Brusko
    • , Michael Clare-Salzler
    • , Harry Nick
    • , Kevin Otto
    • , Amanda Posgai
    • , Clive Wasserfall
    • , Marda Jorgensen
    • , Maigan Brusko
    • , Sergio Maffioletti
    • , Richard M. Caprioli
    • , Jeffrey M. Spraggins
    • , Danielle Gutierrez
    • , Nathan Heath Patterson
    • , Elizabeth K. Neumann
    • , Raymond Harris
    • , Mark deCaestecker
    • , Agnes B. Fogo
    • , Raf van de Plas
    • , Ken Lau
    • , Long Cai
    • , Guo-Cheng Yuan
    • , Qian Zhu
    • , Ruben Dries
    • , Peng Yin
    • , Sinem K. Saka
    • , Jocelyn Y. Kishi
    • , Yu Wang
    • , Isabel Goldaracena
    • , Julia Laskin
    • , DongHye Ye
    • , Kristin E. Burnum-Johnson
    • , Paul D. Piehowski
    • , Charles Ansong
    • , Ying Zhu
    • , Pehr Harbury
    • , Tushar Desai
    • , Jay Mulye
    • , Peter Chou
    • , Monica Nagendran
    • , Ziv Bar-Joseph
    • , Sarah A. Teichmann
    • , Benedict Paten
    • , Robert F. Murphy
    • , Jian Ma
    • , Vladimir Yu. Kiselev
    • , Carl Kingsford
    • , Allyson Ricarte
    • , Maria Keays
    • , Sushma A. Akoju
    • , Matthew Ruffalo
    • , Nils Gehlenborg
    • , Peter Kharchenko
    • , Margaret Vella
    • , Chuck McCallum
    • , Katy Börner
    • , Leonard E. Cross
    • , Samuel H. Friedman
    • , Randy Heiland
    • , Bruce Herr II
    • , Paul Macklin
    • , Ellen M. Quardokus
    • , Lisel Record
    • , James P. Sluka
    • , Griffin M. Weber
    • , Nicholas A. Nystrom
    • , Jonathan C. Silverstein
    • , Philip D. Blood
    • , Alexander J. Ropelewski
    • , William E. Shirey
    • , Robin M. Scibek
    • , Paula Mabee
    • , W. Christopher Lenhardt
    • , Kimberly Robasky
    • , Stavros Michailidis
    • , Rahul Satija
    • , John Marioni
    • , Aviv Regev
    • , Andrew Butler
    • , Tim Stuart
    • , Eyal Fisher
    • , Shila Ghazanfar
    • , Jennifer Rood
    • , Leslie Gaffney
    • , Gokcen Eraslan
    • , Tommaso Biancalani
    • , Eeshit D. Vaishnav
    • , Richard Conroy
    • , Dena Procaccini
    • , Ananda Roy
    • , Ajay Pillai
    • , Marishka Brown
    • , Zorina Galis
    • , Pothur Srinivas
    • , Aaron Pawlyk
    • , Salvatore Sechi
    • , Elizabeth Wilder
    •  & James Anderson

  • Article |

    • P. Ramachandran
    • , R. Dobie
    • , J. R. Wilson-Kanamori
    • , E. F. Dora
    • , B. E. P. Henderson
    • , N. T. Luu
    • , J. R. Portman
    • , K. P. Matchett
    • , M. Brice
    • , J. A. Marwick
    • , R. S. Taylor
    • , M. Efremova
    • , R. Vento-Tormo
    • , N. O. Carragher
    • , T. J. Kendall
    • , J. A. Fallowfield
    • , E. M. Harrison
    • , D. J. Mole
    • , S. J. Wigmore
    • , P. N. Newsome
    • , C. J. Weston
    • , J. P. Iredale
    • , F. Tacke
    • , J. W. Pollard
    • , C. P. Ponting
    • , J. C. Marioni
    • , S. A. Teichmann
    •  & N. C. Henderson

  • Article |

    • Hiromichi Suzuki
    • , Sachin A. Kumar
    • , Shimin Shuai
    • , Ander Diaz-Navarro
    • , Ana Gutierrez-Fernandez
    • , Pasqualino De Antonellis
    • , Florence M. G. Cavalli
    • , Kyle Juraschka
    • , Hamza Farooq
    • , Ichiyo Shibahara
    • , Maria C. Vladoiu
    • , Jiao Zhang
    • , Namal Abeysundara
    • , David Przelicki
    • , Patryk Skowron
    • , Nicole Gauer
    • , Betty Luu
    • , Craig Daniels
    • , Xiaochong Wu
    • , Antoine Forget
    • , Ali Momin
    • , Jun Wang
    • , Weifan Dong
    • , Seung-Ki Kim
    • , Wieslawa A. Grajkowska
    • , Anne Jouvet
    • , Michelle Fèvre-Montange
    • , Maria Luisa Garrè
    • , Amulya A. Nageswara Rao
    • , Caterina Giannini
    • , Johan M. Kros
    • , Pim J. French
    • , Nada Jabado
    • , Ho-Keung Ng
    • , Wai Sang Poon
    • , Charles G. Eberhart
    • , Ian F. Pollack
    • , James M. Olson
    • , William A. Weiss
    • , Toshihiro Kumabe
    • , Enrique López-Aguilar
    • , Boleslaw Lach
    • , Maura Massimino
    • , Erwin G. Van Meir
    • , Joshua B. Rubin
    • , Rajeev Vibhakar
    • , Lola B. Chambless
    • , Noriyuki Kijima
    • , Almos Klekner
    • , László Bognár
    • , Jennifer A. Chan
    • , Claudia C. Faria
    • , Jiannis Ragoussis
    • , Stefan M. Pfister
    • , Anna Goldenberg
    • , Robert J. Wechsler-Reya
    • , Swneke D. Bailey
    • , Livia Garzia
    • , A. Sorana Morrissy
    • , Marco A. Marra
    • , Xi Huang
    • , David Malkin
    • , Olivier Ayrault
    • , Vijay Ramaswamy
    • , Xose S. Puente
    • , John A. Calarco
    • , Lincoln Stein
    •  & Michael D. Taylor

  • Letter |

    A genetically encoded fluorescent voltage indicator, SomArchon, is used to image changes in membrane voltage from many neurons simultaneously in multiple brain regions of awake, behaving mice.

    • Kiryl D. Piatkevich
    • , Seth Bensussen
    • , Hua-an Tseng
    • , Sanaya N. Shroff
    • , Violeta Gisselle Lopez-Huerta
    • , Demian Park
    • , Erica E. Jung
    • , Or A. Shemesh
    • , Christoph Straub
    • , Howard J. Gritton
    • , Michael F. Romano
    • , Emma Costa
    • , Bernardo L. Sabatini
    • , Zhanyan Fu
    • , Edward S. Boyden
    •  & Xue Han

  • Article |

    Changes in the average size distribution of earthquakes are used to discriminate between foreshocks and aftershocks, and a traffic light classification is proposed for the real-time assessment of the probability of a subsequent larger event.

    • Laura Gulia
    •  & Stefan Wiemer

  • News & Views |

    When a big earthquake occurs, it is hard to tell if it will be followed by a larger quake or by only smaller ones. A method has been developed that aims to distinguish between these scenarios while events are still unfolding.

    • Emily E. Brodsky

  • Letter |

    The histidine–aspartate kinase Sln1 acts as a molecular sensor of turgor in appressoria of the rice blast fungus Magnaporthe oryzae, enabling penetration of the host leaf cuticle and plant infection.

    • Lauren S. Ryder
    • , Yasin F. Dagdas
    • , Michael J. Kershaw
    • , Chandrasekhar Venkataraman
    • , Anotida Madzvamuse
    • , Xia Yan
    • , Neftaly Cruz-Mireles
    • , Darren M. Soanes
    • , Miriam Oses-Ruiz
    • , Vanessa Styles
    • , Jan Sklenar
    • , Frank L. H. Menke
    •  & Nicholas J. Talbot

  • Letter |

    A six-coordinate transition-metal complex with a hexagonal planar geometry is isolated and characterized.

    • Martí Garçon
    • , Clare Bakewell
    • , George A. Sackman
    • , Andrew J. P. White
    • , Richard I. Cooper
    • , Alison J. Edwards
    •  & Mark R. Crimmin

  • Futures |

    Brought down to Earth.

    • Timothy J. Gawne

  • Letter |

    Characterization of a capillary flow phenomenon termed self-coalescence leads to the development of scalable, compact microfluidic devices that could see application in diagnostics, high-throughput screening and biological assays.

    • Onur Gökçe
    • , Samuel Castonguay
    • , Yuksel Temiz
    • , Thomas Gervais
    •  & Emmanuel Delamarche

  • Letter |

    An analogue quantum simulator based on ultracold atoms in optical lattices and cavity quantum electrodynamics is proposed for the solution of quantum chemistry problems and tested numerically for a simple molecule.

    • Javier Argüello-Luengo
    • , Alejandro González-Tudela
    • , Tao Shi
    • , Peter Zoller
    •  & J. Ignacio Cirac

  • World View |

    For World Food Day, Esther Ngumbi calls on institutions of higher education to help students know where their next meal is coming from.

    • Esther Ngumbi

  • News & Views |

    Microfluidic devices have revolutionized biological assays, but complex set-ups are required to prevent the unwanted mixing of reagents in the liquid samples being analysed. A simpler solution has just been found.

    • Robert Hołyst
    •  & Piotr Garstecki

  • Comment |

    Biological advances have repeatedly changed who we think we are, writes Nathaniel Comfort, in the third essay of a series marking Nature’s anniversary on how the past 150 years have shaped science today.

    • Nathaniel Comfort

  • News |

    Michel Mayor and Didier Queloz, who discovered the first extrasolar planet orbiting a Sun-like star, share award with theoretical cosmologist James Peebles.

    • Elizabeth Gibney
    •  & Davide Castelvecchi