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  • Nature Briefing |

    Piped-in sounds of a healthy reef tempt young fish to re-colonize degraded areas. Plus: The San Andreas and Cascadia earthquake faults might be linked and how to build a better malaria vaccine.

    • Flora Graham

  • Obituary |

    Biochemist whose discoveries led to faster, more-accurate DNA testing.

    • Jesús Avila
    • , Federico Mayor
    •  & Lourdes Ruiz-Desviat

  • Career Column |

    It’s tempting to stay a ‘silent member’, but you might be missing out on conferences, collaborations and publications, says Elena Schneider-Futschik.

    • Elena Schneider-Futschik

  • Nature Briefing |

    Most forecasts published between 1970 and 2007 did a good job of predicting global warming. Plus: NASA’s daring solar probe discovers the secrets of the solar wind and cell biologists visualize a world of a thousand dimensions.

    • Flora Graham

  • Career Q&A |

    Wildfires are becoming more and more frequent around the world, making expertise in the field a hot commodity.

    • Stav Dimitropoulos

  • Article |

    Chimeric antigen receptor (CAR) T cells engineered to overexpress the canonical AP-1 transcription factor c-Jun are resistant to T cell exhaustion, and provide enhanced therapeutic benefit in mouse tumour models.

    • Rachel C. Lynn
    • , Evan W. Weber
    • , Elena Sotillo
    • , David Gennert
    • , Peng Xu
    • , Zinaida Good
    • , Hima Anbunathan
    • , John Lattin
    • , Robert Jones
    • , Victor Tieu
    • , Surya Nagaraja
    • , Jeffrey Granja
    • , Charles F. A. de Bourcy
    • , Robbie Majzner
    • , Ansuman T. Satpathy
    • , Stephen R. Quake
    • , Michelle Monje
    • , Howard Y. Chang
    •  & Crystal L. Mackall

  • News & Views |

    Scattering between electrons in the material graphene can cause these particles to flow like a viscous liquid. Such flow, which has previously been detected using measurements of electrical resistance, has now been visualized.

    • Klaus Ensslin

  • Innovations In |

    After false starts, drugs that manipulate the code of life are finally changing lives.

    • Jim Daley

  • Article |

    Titanium–copper alloys with fully equiaxed grains and a fine microstructure are realized via an additive manufacturing process that exploits high cooling rates and multiple thermal cycles.

    • Duyao Zhang
    • , Dong Qiu
    • , Mark A. Gibson
    • , Yufeng Zheng
    • , Hamish L. Fraser
    • , David H. StJohn
    •  & Mark A. Easton

  • Article |

    Observations of an accretion disk around a hot white dwarf star reveal that the chemical abundances in its disk are similar to those thought to exist deep in icy giant planets, so the white dwarf must be accreting a giant planet.

    • Boris T. Gänsicke
    • , Matthias R. Schreiber
    • , Odette Toloza
    • , Nicola P. Gentile Fusillo
    • , Detlev Koester
    •  & Christopher J. Manser

  • Article |

    Frontal cortex neurons can be grouped into categorical response types corresponding to particular decision variables, such as reward size, decision confidence, or value, and individual variables may be encoded in distinct projection populations; this suggests that, like  neurons in sensory cortex, frontal neurons form a sparse and overcomplete representation of important variables in the environment.

    • Junya Hirokawa
    • , Alexander Vaughan
    • , Paul Masset
    • , Torben Ott
    •  & Adam Kepecs

  • Article |

    Analyses of primary and relapse samples of embryonal tumours with multilayered rosettes provide insights into the molecular mechanisms that underlie the development and opportunities for the treatment of this deadly disease.

    • Sander Lambo
    • , Susanne N. Gröbner
    • , Tobias Rausch
    • , Sebastian M. Waszak
    • , Christin Schmidt
    • , Aparna Gorthi
    • , July Carolina Romero
    • , Monika Mauermann
    • , Sebastian Brabetz
    • , Sonja Krausert
    • , Ivo Buchhalter
    • , Jan Koster
    • , Danny A. Zwijnenburg
    • , Martin Sill
    • , Jens-Martin Hübner
    • , Norman Mack
    • , Benjamin Schwalm
    • , Marina Ryzhova
    • , Volker Hovestadt
    • , Simon Papillon-Cavanagh
    • , Jennifer A. Chan
    • , Pablo Landgraf
    • , Ben Ho
    • , Till Milde
    • , Olaf Witt
    • , Jonas Ecker
    • , Felix Sahm
    • , David Sumerauer
    • , David W. Ellison
    • , Brent A. Orr
    • , Anna Darabi
    • , Christine Haberler
    • , Dominique Figarella-Branger
    • , Pieter Wesseling
    • , Jens Schittenhelm
    • , Marc Remke
    • , Michael D. Taylor
    • , Maria J. Gil-da-Costa
    • , Maria Łastowska
    • , Wiesława Grajkowska
    • , Martin Hasselblatt
    • , Peter Hauser
    • , Torsten Pietsch
    • , Emmanuelle Uro-Coste
    • , Franck Bourdeaut
    • , Julien Masliah-Planchon
    • , Valérie Rigau
    • , Sanda Alexandrescu
    • , Stephan Wolf
    • , Xiao-Nan Li
    • , Ulrich Schüller
    • , Matija Snuderl
    • , Matthias A. Karajannis
    • , Felice Giangaspero
    • , Nada Jabado
    • , Andreas von Deimling
    • , David T. W. Jones
    • , Jan O. Korbel
    • , Katja von Hoff
    • , Peter Lichter
    • , Annie Huang
    • , Alexander J. R. Bishop
    • , Stefan M. Pfister
    • , Andrey Korshunov
    •  & Marcel Kool

  • News & Views |

    NASA’s Parker Solar Probe is currently making a series of close encounters with the Sun. Initial observations from the spacecraft have improved our understanding of both the Sun and its environment.

    • Daniel Verscharen

  • Article |

    RITF1, a newly identified plant transcription factor, links signalling through the peptide hormone RGF1 to the balance of reactive oxygen species and thereby enhances the stability of another transcription factor, PLETHORA2, a master regulator of root stem cells.

    • Masashi Yamada
    • , Xinwei Han
    •  & Philip N. Benfey

  • Innovations In |

    DNA-based medicine needs more diversity to avoid harmful bias. One big research project is fixing that.

    • Stephanie Devaney

  • Article
    | Open Access

    Using whole-genome sequencing data from 1,739 individuals, the GenomeAsia 100K Project catalogues genetic variation, population structure and disease associations to facilitate genetic studies in Asian populations and increase representation in genetics studies worldwide.

    • Jeffrey D. Wall
    • , Eric W. Stawiski
    • , Aakrosh Ratan
    • , Hie Lim Kim
    • , Changhoon Kim
    • , Ravi Gupta
    • , Kushal Suryamohan
    • , Elena S. Gusareva
    • , Rikky Wenang Purbojati
    • , Tushar Bhangale
    • , Vadim Stepanov
    • , Vladimir Kharkov
    • , Markus S. Schröder
    • , Vedam Ramprasad
    • , Jennifer Tom
    • , Steffen Durinck
    • , Qixin Bei
    • , Jiani Li
    • , Joseph Guillory
    • , Sameer Phalke
    • , Analabha Basu
    • , Jeremy Stinson
    • , Sandhya Nair
    • , Sivasankar Malaichamy
    • , Nidhan K. Biswas
    • , John C. Chambers
    • , Keith C. Cheng
    • , Joyner T. George
    • , Seik Soon Khor
    • , Jong-Il Kim
    • , Belong Cho
    • , Ramesh Menon
    • , Thiramsetti Sattibabu
    • , Akshi Bassi
    • , Manjari Deshmukh
    • , Anjali Verma
    • , Vivek Gopalan
    • , Jong-Yeon Shin
    • , Mahesh Pratapneni
    • , Sam Santhosh
    • , Katsushi Tokunaga
    • , Badrul M. Md-Zain
    • , Kok Gan Chan
    • , Madasamy Parani
    • , Purushothaman Natarajan
    • , Michael Hauser
    • , R. Rand Allingham
    • , Cecilia Santiago-Turla
    • , Arkasubhra Ghosh
    • , Santosh Gopi Krishna Gadde
    • , Christian Fuchsberger
    • , Lukas Forer
    • , Sebastian Schoenherr
    • , Herawati Sudoyo
    • , J. Stephen Lansing
    • , Jonathan Friedlaender
    • , George Koki
    • , Murray P. Cox
    • , Michael Hammer
    • , Tatiana Karafet
    • , Khai C. Ang
    • , Syed Q. Mehdi
    • , Venkatesan Radha
    • , Viswanathan Mohan
    • , Partha P. Majumder
    • , Somasekar Seshagiri
    • , Jeong-Sun Seo
    • , Stephan C. Schuster
    •  & Andrew S. Peterson

  • Article |

    Data collected by the Parker Solar Probe in the solar corona are used to determine the organization of Alfvén waves, revealing an increasing flow velocity peaking at 35–50 km s−1.

    • J. C. Kasper
    • , S. D. Bale
    • , J. W. Belcher
    • , M. Berthomier
    • , A. W. Case
    • , B. D. G. Chandran
    • , D. W. Curtis
    • , D. Gallagher
    • , S. P. Gary
    • , L. Golub
    • , J. S. Halekas
    • , G. C. Ho
    • , T. S. Horbury
    • , Q. Hu
    • , J. Huang
    • , K. G. Klein
    • , K. E. Korreck
    • , D. E. Larson
    • , R. Livi
    • , B. Maruca
    • , B. Lavraud
    • , P. Louarn
    • , M. Maksimovic
    • , M. Martinovic
    • , D. McGinnis
    • , N. V. Pogorelov
    • , J. D. Richardson
    • , R. M. Skoug
    • , J. T. Steinberg
    • , M. L. Stevens
    • , A. Szabo
    • , M. Velli
    • , P. L. Whittlesey
    • , K. H. Wright
    • , G. P. Zank
    • , R. J. MacDowall
    • , D. J. McComas
    • , R. L. McNutt Jr
    • , M. Pulupa
    • , N. E. Raouafi
    •  & N. A. Schwadron

  • Article |

    Anoxygenic photosynthetic microorganisms can biomineralize manganese oxides without molecular oxygen being present and without high-potential photosynthetic reaction centres, which sheds doubt on proposed dates for the origins of oxygenic photosynthetic metabolism.

    • Mirna Daye
    • , Vanja Klepac-Ceraj
    • , Mihkel Pajusalu
    • , Sophie Rowland
    • , Anna Farrell-Sherman
    • , Nicolas Beukes
    • , Nobumichi Tamura
    • , Gregory Fournier
    •  & Tanja Bosak

  • Innovations In |

    We now have the ability to screen for thousands of genetic diseases in newborns. That may not always be the healthy thing to do.

    • Tanya Lewis

  • Article |

    The Parker Solar Probe mission has reached the inner heliosphere of the Sun and made measurements of energetic particle events in the near-Sun radiation environment.

    • D. J. McComas
    • , E. R. Christian
    • , C. M. S. Cohen
    • , A. C. Cummings
    • , A. J. Davis
    • , M. I. Desai
    • , J. Giacalone
    • , M. E. Hill
    • , C. J. Joyce
    • , S. M. Krimigis
    • , A. W. Labrador
    • , R. A. Leske
    • , O. Malandraki
    • , W. H. Matthaeus
    • , R. L. McNutt Jr
    • , R. A. Mewaldt
    • , D. G. Mitchell
    • , A. Posner
    • , J. S. Rankin
    • , E. C. Roelof
    • , N. A. Schwadron
    • , E. C. Stone
    • , J. R. Szalay
    • , M. E. Wiedenbeck
    • , S. D. Bale
    • , J. C. Kasper
    • , A. W. Case
    • , K. E. Korreck
    • , R. J. MacDowall
    • , M. Pulupa
    • , M. L. Stevens
    •  & A. P. Rouillard

  • Article |

    precisely controllable integrated optical gyroscope based on stimulated Brillouin scattering is used to study non-Hermitian physics, revealing a four-fold enhancement of the Sagnac scale factor near exceptional points.

    • Yu-Hung Lai
    • , Yu-Kun Lu
    • , Myoung-Gyun Suh
    • , Zhiquan Yuan
    •  & Kerry Vahala

  • Review Article |

    A Review of studies into insulin resistance and hepatic gluconeogenesis associated with obesity and type 2 diabetes.

    • Michael Roden
    •  & Gerald I. Shulman

  • News |

    The trend is driven by progress tackling the disease in southeast Asia, but elsewhere infections remain 'unacceptably high'.

    • Giorgia Guglielmi

  • News & Views |

    Conventional alloys have undesirably coarse-grained microstructures when used in 3D printing. A designer alloy overcomes this problem, potentially opening the way to the widespread adoption of 3D metal printing.

    • Amy J. Clarke

  • Article |

    The emergence of a liquid-like electronic flow from ballistic flow in graphene is imaged, and an almost-ideal viscous hydrodynamic fluid of electrons exhibiting a parabolic Poiseuille flow profile is observed.

    • Joseph A. Sulpizio
    • , Lior Ella
    • , Asaf Rozen
    • , John Birkbeck
    • , David J. Perello
    • , Debarghya Dutta
    • , Moshe Ben-Shalom
    • , Takashi Taniguchi
    • , Kenji Watanabe
    • , Tobias Holder
    • , Raquel Queiroz
    • , Alessandro Principi
    • , Ady Stern
    • , Thomas Scaffidi
    • , Andre K. Geim
    •  & Shahal Ilani

  • Article |

    Chaperones interact with a canonical motif in α-synuclein, which can be prevented by phosphorylation of α-synuclein at Tyr39, whereas inhibition of this interaction leads to the localization of α-synuclein to the mitochondria and aggregate formation.

    • Björn M. Burmann
    • , Juan A. Gerez
    • , Irena Matečko-Burmann
    • , Silvia Campioni
    • , Pratibha Kumari
    • , Dhiman Ghosh
    • , Adam Mazur
    • , Emelie E. Aspholm
    • , Darius Šulskis
    • , Magdalena Wawrzyniuk
    • , Thomas Bock
    • , Alexander Schmidt
    • , Stefan G. D. Rüdiger
    • , Roland Riek
    •  & Sebastian Hiller

  • Article |

    Observations of the solar corona by the Parker Solar Probe reveal evidence for the predicted dust-free zone and confirm that streamers comprise smaller substreamers that channel continuous multiscale density fluctuations.

    • R. A. Howard
    • , A. Vourlidas
    • , V. Bothmer
    • , R. C. Colaninno
    • , C. E. DeForest
    • , B. Gallagher
    • , J. R. Hall
    • , P. Hess
    • , A. K. Higginson
    • , C. M. Korendyke
    • , A. Kouloumvakos
    • , P. L. Lamy
    • , P. C. Liewer
    • , J. Linker
    • , M. Linton
    • , P. Penteado
    • , S. P. Plunkett
    • , N. Poirier
    • , N. E. Raouafi
    • , N. Rich
    • , P. Rochus
    • , A. P. Rouillard
    • , D. G. Socker
    • , G. Stenborg
    • , A. F. Thernisien
    •  & N. M. Viall

  • Innovations In |

    DNA or RNA molecules, arranged into spherical shapes, can attack brain cancers and other illnesses that evade conventional drug design.

    • Chad A. Mirkin
    • , Christine Laramy
    •  & Kacper Skakuj

  • Article |

    A subpopulation of Caenorhabditis elegans, in which there is a naturally occurring transient increase in reactive oxygen species during early development, exhibits increased stress resistance, improved redox homeostasis and prolonged lifespan, which are linked to a global decrease in level of the histone mark H3K4me3.

    • Daphne Bazopoulou
    • , Daniela Knoefler
    • , Yongxin Zheng
    • , Kathrin Ulrich
    • , Bryndon J. Oleson
    • , Lihan Xie
    • , Minwook Kim
    • , Anke Kaufmann
    • , Young-Tae Lee
    • , Yali Dou
    • , Yong Chen
    • , Shu Quan
    •  & Ursula Jakob

  • Article |

    The chromatin regulator CTCF has key roles in the gradual development of hierarchical chromatin structure during human embryogenesis.

    • Xuepeng Chen
    • , Yuwen Ke
    • , Keliang Wu
    • , Han Zhao
    • , Yaoyu Sun
    • , Lei Gao
    • , Zhenbo Liu
    • , Jingye Zhang
    • , Wenrong Tao
    • , Zhenzhen Hou
    • , Hui Liu
    • , Jiang Liu
    •  & Zi-Jiang Chen

  • Article |

    A method based on non-Hermitian singularities, or exceptional points, is established and used to increase the Sagnac scale factor and enhance the sensitivity of ring-laser gyroscopes.

    • Mohammad P. Hokmabadi
    • , Alexander Schumer
    • , Demetrios N. Christodoulides
    •  & Mercedeh Khajavikhan