Browse Articles

  • Author Correction |

    • T. B. Miller
    • , S. C. Chapman
    • , M. Aravena
    • , M. L. N. Ashby
    • , C. C. Hayward
    • , J. D. Vieira
    • , A. Weiß
    • , A. Babul
    • , M. Béthermin
    • , C. M. Bradford
    • , M. Brodwin
    • , J. E. Carlstrom
    • , Chian-Chou Chen
    • , D. J. M. Cunningham
    • , C. De Breuck
    • , A. H. Gonzalez
    • , T. R. Greve
    • , J. Harnett
    • , Y. Hezaveh
    • , K. Lacaille
    • , K. C. Litke
    • , J. Ma
    • , M. Malkan
    • , D. P. Marrone
    • , W. Morningstar
    • , E. J. Murphy
    • , D. Narayanan
    • , E. Pass
    • , R. Perry
    • , K. A. Phadke
    • , D. Rennehan
    • , K. M. Rotermund
    • , J. Simpson
    • , J. S. Spilker
    • , J. Sreevani
    • , A. A. Stark
    • , M. L. Strandet
    •  & A. L. Strom
  • News & Views |

    The location of nearly half of the ordinary matter in the Universe is unknown. X-ray observations suggest that this elusive ‘baryonic’ matter is hidden in the filamentary structure of the cosmic web.

    • Taotao Fang
  • Article |

    The cryo-electron microscopy structure of the human adenosine A1 receptor in complex with adenosine and heterotrimeric Gi2 protein provides molecular insights into receptor and G-protein selectivity.

    • Christopher J. Draper-Joyce
    • , Maryam Khoshouei
    • , David M. Thal
    • , Yi-Lynn Liang
    • , Anh T. N. Nguyen
    • , Sebastian G. B. Furness
    • , Hariprasad Venugopal
    • , Jo-Anne Baltos
    • , Jürgen M. Plitzko
    • , Radostin Danev
    • , Wolfgang Baumeister
    • , Lauren T. May
    • , Denise Wootten
    • , Patrick M. Sexton
    • , Alisa Glukhova
    •  & Arthur Christopoulos
  • Comment |

    Systematic reviews have transformed medicine, but a more cost-effective means of appraisal is needed for fields in which data are sparse and patchy, argue William J. Sutherland and Claire F. R. Wordley.

    • William J. Sutherland
    •  & Claire F. R. Wordley
  • Letter |

    Enzymes that catalyse modifications of wobble uridine 34 tRNA are essential for the survival of melanoma cells that rely on HIF1α-dependent metabolism through codon-dependent regulation of the translation of HIF1A mRNA.

    • Francesca Rapino
    • , Sylvain Delaunay
    • , Florian Rambow
    • , Zhaoli Zhou
    • , Lars Tharun
    • , Pascal De Tullio
    • , Olga Sin
    • , Kateryna Shostak
    • , Sebastian Schmitz
    • , Jolanda Piepers
    • , Bart Ghesquière
    • , Latifa Karim
    • , Benoit Charloteaux
    • , Diane Jamart
    • , Alexandra Florin
    • , Charles Lambert
    • , Andrée Rorive
    • , Guy Jerusalem
    • , Eleonora Leucci
    • , Michael Dewaele
    • , Marc Vooijs
    • , Sebastian A. Leidel
    • , Michel Georges
    • , Marianne Voz
    • , Bernard Peers
    • , Reinhard Büttner
    • , Jean-Christophe Marine
    • , Alain Chariot
    •  & Pierre Close
  • Letter |

    The electrointercalation of lithium into van der Waals heterostructures of graphene, hexagonal boron nitride and molybdenum dichalcogenides is studied at the level of individual atomic interfaces.

    • D. Kwabena Bediako
    • , Mehdi Rezaee
    • , Hyobin Yoo
    • , Daniel T. Larson
    • , S. Y. Frank Zhao
    • , Takashi Taniguchi
    • , Kenji Watanabe
    • , Tina L. Brower-Thomas
    • , Efthimios Kaxiras
    •  & Philip Kim
  • Comment |

    Reward the creation of analyses for policymakers that are inclusive, rigorous, transparent and accessible, urge Christl A. Donnelly and colleagues.

    • Christl A. Donnelly
    • , Ian Boyd
    • , Philip Campbell
    • , Claire Craig
    • , Patrick Vallance
    • , Mark Walport
    • , Christopher J. M. Whitty
    • , Emma Woods
    •  & Chris Wormald
  • Letter |

    The high-resolution structure of the serotonin 5-HT1B receptor in complex with the agonist donitriptan and a Go heterotrimer highlights features that may underly the specificity of receptor–G-protein coupling and kinetics of signalling.

    • Javier García-Nafría
    • , Rony Nehmé
    • , Patricia C. Edwards
    •  & Christopher G. Tate
  • News & Views |

    The assembly of polymerized actin with motor proteins at DNA breaks in the nucleus supports the mobility and repair of DNA. This finding reveals a layer of regulation that helps to preserve genome integrity.

    • Vassilis Roukos
  • Article |

    Polymerization of actin in the cell nucleus, promoted by the ARP2/3 complex, drives the clustering of double-strand DNA breaks into nuclear compartments where they can undergo homology-directed repair.

    • Benjamin R. Schrank
    • , Tomas Aparicio
    • , Yinyin Li
    • , Wakam Chang
    • , Brian T. Chait
    • , Gregg G. Gundersen
    • , Max E. Gottesman
    •  & Jean Gautier
  • Letter |

    An analysis based on functional metagenomics reveals a previously unknown group of microbial light-sensory rhodopsins that are widespread among a diverse range of microorganisms.

    • Alina Pushkarev
    • , Keiichi Inoue
    • , Shirley Larom
    • , José Flores-Uribe
    • , Manish Singh
    • , Masae Konno
    • , Sahoko Tomida
    • , Shota Ito
    • , Ryoko Nakamura
    • , Satoshi P. Tsunoda
    • , Alon Philosof
    • , Itai Sharon
    • , Natalya Yutin
    • , Eugene V. Koonin
    • , Hideki Kandori
    •  & Oded Béjà
  • Letter |

     In the midbrain defensive circuit, the decision to escape is computed by an unreliable synaptic connection that thresholds threat information integrated in the medial superior colliculus, and controls activation of dorsal periaqueductal grey neurons.

    • Dominic A. Evans
    • , A. Vanessa Stempel
    • , Ruben Vale
    • , Sabine Ruehle
    • , Yaara Lefler
    •  & Tiago Branco