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An etched fiber-optic bundle used to create a self-assembled bead array for the analysis of alternatively spliced mRNAs (see Fu and colleagues, p.353). A pit at the tip of each fiber holds a 3.1 micron bead bearing between 500,000 and 750,000 oligonucleotides. Binding of labeled sample oligonucleotides is detected by a camera at the other end of the fibers.
Living cells provide the starting material for a cornucopia of new strategies for the treatment of disease, despite several outstanding bureaucratic and technical obstacles.