Nature Biotechnology

Volume 35 Issue 12, December 2017

The central sinus of mouse bone marrow, stained with antibodies for CD105 (cyan; endothelial and hematopoietic cells), Sca1 (magenta; hematopoietic cells, arteries and arterioles) and SM22 (white; smooth muscle cells). Coutu et al. (p 1202) present a detailed atlas of cell-type distribution and marker expression patterns in the bone marrow of mice. Credit: Konstantinos D. Kokkaliaris, Daniel L. Coutu and Leo Kunz

Volume 35 Issue 12

Editorial

Methods, preprints and papers

This journal supports preprints as a means to rapidly share research, but discourages their use as stand-alone citations disclosing a new method integral to the key results in a paper.

Editorial 08 Dec 2017

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News

Ablynx's nanobody fragments go places antibodies cannot

Cormac Sheridan
News 08 Dec 2017
Amgen cholesterol antibody feud could kill key IP rule

Mark Ratner
News 08 Dec 2017
California cracks down on stem cell cowboys

Laura DeFrancesco
News 08 Dec 2017
A new crop of microbe startups raises big bucks, takes on the establishment

Emily Waltz
News 08 Dec 2017
Around the world in a month

News 08 Dec 2017
The Broad and Johns Hopkins lure deep-pocketed investors

Eva von Schaper
News 08 Dec 2017
Activists bury India's GM mustard hopes

Killugudi Jayaraman
News 08 Dec 2017

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Correction

Corrections

Correction 08 Dec 2017

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Data Page

Drug pipeline 3Q17

Laura DeFrancesco
Data Page 08 Dec 2017
Top 20 translational researchers of 2016

Brady Huggett
Kathryn Paisner
Data Page 08 Dec 2017

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Correspondence

The international MAQC Society launches to enhance reproducibility of high-throughput technologies

Leming Shi
Rebecca Kusko
Weida Tong
Correspondence 08 Dec 2017
Challenges and recommendations for epigenomics in precision health

Ava C Carter
Howard Y Chang
Wing Wong
Correspondence 08 Dec 2017

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Feature

When pig organs will fly

Regulators, scientists and surgeons are preparing the groundwork for human trials of engineered pig organs—and industry is starting to take notice.

Emily Waltz
Feature 08 Dec 2017

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Patents

Will inter partes review speed US generic drug entry?

A new extra-judicial pathway for challenging pharmaceutical patents has intensified patent challenges and helped to clear the way for earlier generic entry.

Jonathan J Darrow
Reed F Beall
Aaron S Kesselheim
Patents 08 Dec 2017
Recent patents in xenotransplantation

Patents 08 Dec 2017

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News & Views

DNA sequencing at ultra-high fidelity

Built-in error-correction and novel fluorogenic chemistry open a path to perfect read quality.

Robert Sebra
News & Views 30 Oct 2017
Tuning up T-cell receptors

T-cell receptors with higher affinity for tumor antigens are discovered by harnessing T-cell development.

C Garrett Rappazzo
Michael E Birnbaum
News & Views 06 Nov 2017
Research Highlights

News & Views 08 Dec 2017
MAGE in yeast is a go

Susan Jones
News & Views 08 Dec 2017

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Perspective

Just how good an investment is the biopharmaceutical sector?

An analysis of biotech and pharma stock prices since 1930 reveals sharp differences in the risk-adjusted returns of the two sectors.

Richard T Thakor
Nicholas Anaya
Andrew W Lo
Perspective 08 Dec 2017

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Review Article

Microbial synthesis of medium-chain chemicals from renewables

Strategies to engineer microorganisms to produce medium-chain hydrocarbon chemicals are reviewed.

Stephen Sarria
Nicholas S Kruyer
Pamela Peralta-Yahya
Review Article 08 Dec 2017

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Brief Communication

Accurate assembly of transcripts through phase-preserving graph decomposition

Scallop improves identification of multi-exon and transcripts expressed at low levels by retaining phasing information during assembly.

Mingfu Shao
Carl Kingsford
Brief Communication 13 Nov 2017

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Article

Highly accurate fluorogenic DNA sequencing with information theory–based error correction

The error rate of DNA sequencing is much reduced by combining an improved fluorogenic sequencing chemistry with a new error-correction scheme.

Zitian Chen
Wenxiong Zhou
Yanyi Huang
Article 06 Nov 2017
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing

Efficient Cas9 genome editing in vivo is achieved without viral vectors using chemically modified single-guide RNAs.

Hao Yin
Chun-Qing Song
Daniel G Anderson
Article 13 Nov 2017
Generation of higher affinity T cell receptors by antigen-driven differentiation of progenitor T cells in vitro

The affinity of T cells for tumor self-antigens is improved by a culture system that identifies optimal T-cell-receptor B chains.

Thomas M Schmitt
David H Aggen
Philip D Greenberg
Article 06 Nov 2017

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Letter

Cell-type-specific metabolic labeling of nascent proteomes in vivo

Proteomes of distinct cell types in the brains of live mice are labeled and quantitated with a genetically encoded non-canonical amino-acid labeling method and click chemistry.

Beatriz Alvarez-Castelao
Christoph T Schanzenbächer
Erin M Schuman
Letter 06 Nov 2017

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Resource

Three-dimensional map of nonhematopoietic bone and bone-marrow cells and molecules

A compendium detailing the localization of bone and bone-marrow-microenvironment cells and proteins will enable efforts to understand the functions of this niche.

Daniel L Coutu
Konstantinos D Kokkaliaris
Timm Schroeder
Resource 13 Nov 2017

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Corrigendum

Correction: Corrigendum: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

Jatin Roper
Tuomas Tammela
Ömer H Yilmaz
Corrigendum 08 Dec 2017
Correction: Corrigendum: Shotgun metagenomics, from sampling to analysis

Christopher Quince
Alan W Walker
Nicola Segata
Corrigendum 08 Dec 2017
Correction: Corrigendum: Development and function of human innate immune cells in a humanized mouse model

Anthony Rongvaux
Tim Willinger
Richard A Flavell
Corrigendum 08 Dec 2017

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Erratum

Erratum: Revisiting the Warnock rule

J Benjamin Hurlbut
Insoo Hyun
Laurie Zoloth
Erratum 08 Dec 2017

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Careers and Recruitment

Institutional culture is the key to team science

Institutional leadership in creating a culture of cooperation and pathways for multidisciplinary collaboration is critical to achieving the goals of academic translation and innovation.

Sandra Soo-Jin Lee
Anna Jabloner
Careers and Recruitment 08 Dec 2017
People

Careers and Recruitment 08 Dec 2017

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