Volume 40 Issue 10, October 2022

Extrahepatic delivery of RNA therapeutics

A model of 2&#x2032-O-hexadecyl (C16)-conjugated siRNA (orange) in complex with RISC (white) and mRNA (green). Brown et al. show that C16-conjugated siRNA achieves efficient, durable targeted gene silencing in the central nervous system, eye and lung.

See Brown et al.

Image: Alnylam Pharmaceuticals Inc. Cover Design: Erin Dewalt.

News

Repairing the eye

Companies are pursuing interventions to edit, regenerate and reprogram eye tissue to restore lost vision.

Cormac Sheridan
News 07 Oct 2022
Advertisement
CAR-Ts made entirely within the body

News in Brief 07 Oct 2022
Cancer Moonshot aims at liquid biopsies

News in Brief 07 Oct 2022
Precision nutrition to boost cancer treatments

Researchers are designing diets that may improve patient responses to cancer therapy by using machine learning and genotyping to uncover tumors’ nutritional vulnerabilities.

Melanie Senior
News 07 Oct 2022
AI predicts cancer relapse from slides

News in Brief 07 Oct 2022
Baltic bacteria sink CO₂ into smoothies

Vijay Shankar Balakrishnan
News 07 Oct 2022
Biotech news from around the world

News in Brief 07 Oct 2022
Data Page
- Public biotech in 2021 — the numbers
  
  Laura DeFrancesco
  Riku Lähteenmäki
  Data Page 07 Oct 2022

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Features

Patents
- What the COVID-19 pandemic revealed about intellectual property
  
  The COVID-19 pandemic dispelled some myths underlying intellectual property policy and revealed how stakeholders can develop policies to accelerate development and ensure access using existing tools and experimenting with open science.
  
  E. Richard Gold
  Patents 07 Oct 2022
- Optogenetics
  
  Recent patents relating to methods and devices for optogenetic control of cells.
  
  Patents 07 Oct 2022

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Research Highlights

Visualizing protein nanostructures in intact brain

Natalie G. Barnes
Research Highlight 07 Oct 2022
Single-cell RNA-seq keeps cells alive

Eleni Kotsiliti
Research Highlight 07 Oct 2022
De novo protein design with a language model

Eleni Kotsiliti
Research Highlight 07 Oct 2022

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News & Views

Precision cancer targeting with antibody pairs

Logic-gated monoclonal antibodies have been designed to improve safety and efficacy.

Robert T. Lawrence
Peter D. Senter
News & Views 25 Jul 2022
Podcast
- Forum: Teichmann and Regev
  
  Podcast 07 Oct 2022

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Research Briefings

Team architecture in 3D genomic interactions revealed through nanopore sequencing

Are major decisions in the cell made through pairs of interacting loci (enhancers and promoters) or larger teams of cooperating regulatory elements? A new genome-wide assay and algorithm answers this question and provides a scalable technology to link new dimensions of genome structure with cellular function.

Research Briefing 01 Jun 2022
Lipophilic siRNA conjugates yield durable silencing in extrahepatic tissues

RNA interference (RNAi) therapeutics can silence disease-causing gene transcripts, but extrahepatic delivery has been challenging. Conjugating short interfering RNAs (siRNAs) to a lipophilic alkyl chain enabled safe delivery and long-term mRNA silencing in the brain, eye and lung in animal models, thereby opening new applications for RNAi therapeutics.

Research Briefing 08 Jun 2022

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Research

Matters Arising
- Assessing the efficiency of Verily’s automated process for production and release of male Wolbachia-infected mosquitoes
  
  Jérémy Bouyer
  Hamidou Maiga
  Marc J. B. Vreysen
  Matters Arising 26 May 2022
- Reply to: Assessing the efficiency of Verily’s automated process for production and release of male Wolbachia-infected mosquitoes
  
  Jacob E. Crawford
  Kaycie C. Hopkins
  Bradley J. White
  Matters Arising 26 May 2022
Brief Communications
- Fast and highly sensitive full-length single-cell RNA sequencing using FLASH-seq
  
  FLASH-seq speeds up high-sensitivity scRNA-seq while sparing resources.
  
  Vincent Hahaut
  Dinko Pavlinic
  Simone Picelli
  Brief Communication Open Access 30 May 2022
Articles
- Scalable single-cell RNA sequencing from full transcripts with Smart-seq3xpress
  
  Smart-seq3xpress enables single-cell RNA sequencing from full transcripts at high throughput.
  
  Michael Hagemann-Jensen
  Christoph Ziegenhain
  Rickard Sandberg
  Article Open Access 30 May 2022
- Multi-omics single-cell data integration and regulatory inference with graph-linked embedding
  
  Different single-cell data modalities are integrated at atlas-scale by modeling regulatory interactions.
  
  Zhi-Jie Cao
  Ge Gao
  Article Open Access 02 May 2022
- DIALOGUE maps multicellular programs in tissue from single-cell or spatial transcriptomics data
  
  Coordinated gene programs spanning multiple different cell types are identified in healthy and diseased tissues.
  
  Livnat Jerby-Arnon
  Aviv Regev
  Article 05 May 2022
- Comparison and imputation-aided integration of five commercial platforms for targeted DNA methylome analysis
  
  Differences in CpG coverage of targeted bisulfite sequencing methods can be overcome using imputation.
  
  Miljana Tanić
  Ismail Moghul
  Stephan Beck
  Article 02 Jun 2022
- Identifying synergistic high-order 3D chromatin conformations from genome-scale nanopore concatemer sequencing
  
  High-order chromatin contacts are identified using a combination of 3C, nanopore sequencing and robust statistical analysis.
  
  Aditya S. Deshpande
  Netha Ulahannan
  Marcin Imieliński
  Article 30 May 2022
- Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates
  
  Lipophilic siRNA conjugates exert therapeutic activity in the mouse CNS.
  
  Kirk M. Brown
  Jayaprakash K. Nair
  Vasant Jadhav
  Article 02 Jun 2022
- Logic-gated antibody pairs that selectively act on cells co-expressing two antigens
  
  Antibody pairs are made to act selectively on cells co-expressing two targets by engineering their Fc domains.
  
  Simone C. Oostindie
  Derek A. Rinaldi
  Rob N. de Jong
  Article Open Access 25 Jul 2022
- Prediction of protein–ligand binding affinity from sequencing data with interpretable machine learning
  
  Protein–ligand binding affinity is predicted quantitatively from sequencing data.
  
  H. Tomas Rube
  Chaitanya Rastogi
  Harmen J. Bussemaker
  Article Open Access 23 May 2022

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Careers & Recruitment

Career Feature
- Integrating medicine, engineering and business to educate early-stage researchers in cardiovascular device development
  
  Developing a device development educational core will further enhance national, international and multidisciplinary innovation and collaboration in the biomedical device domain.
  
  Gabriel Vizgan
  Zachary Hill-Whilton
  Gabrielle Gold-von Simson
  Career Feature 07 Oct 2022
People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 07 Oct 2022

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Volume 40 Issue 10, October 2022

Extrahepatic delivery of RNA therapeutics

News

Data Page

Features

Patents

Research Highlights

News & Views

Podcast

Research Briefings

Research

Matters Arising

Brief Communications

Articles

Careers & Recruitment

Career Feature

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